gene

CHAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

391Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

CHAT is a gene implicated in neurodegeneration research. Key relationships include: associated with, protects against, regulates. Associated with ALZHEIMER'S, ALZHEIMER'S DISEASE, Als. Connected to 127 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHAT
Chromosome	10q11.23
Function	The reaction mechanism involves
Subcellular Localization	the cytoplasm of presynaptic nerve terminals, but also associates with synaptic vesicles for regulated neurotransmitter
Molecular Weight	70 kDa
Amino Acids	748 aa
Exons	14
Pathways	Apoptosis, Cell Cycle
GeneCards	CHAT
Human Protein Atlas	CHAT
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Anxiety, Dementia
Interactions	ABCB1, ACHE, AD, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Hypotheses	Sensory-Motor Circuit Cross-Modal Compensation
KG Connections	391 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHAT["CHAT"]
    CHAT -->|"interacts"| Rab5a["Rab5a"]
    CHAT -->|"co_expressed_with"| CHRNA7["CHRNA7"]
    CHAT -->|"regulates"| NGF["NGF"]
    CHAT -->|"target for"| Dementia["Dementia"]
    CHAT -.protects against.-> Inflammation["Inflammation"]
    CHAT -.protects against.-> Diabetes["Diabetes"]
    CHAT -.protects against.-> Neurodegeneration["Neurodegeneration"]
    CHAT -.protects against.-> Neuroinflammation["Neuroinflammation"]
    PER["PER"] -->|"interacts"| CHAT

Outgoing (266)

Target	Relation	Type	Str
Rab5a	interacts_with	protein	0.80
CHRNA7	interacts_with	gene	0.80
Alzheimer	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
LDLR	mediates	gene	0.70
CHOLINERGIC	activates	cell_type	0.70
NEURONS	markers	cell_type	0.70
NEURONS	expresses	cell_type	0.70
NEURONS	causes	cell_type	0.70
PSD95	activates	gene	0.70
GRIA1	activates	gene	0.70
CHRNA7	regulates	gene	0.70
NGF	regulates	protein	0.70
Alzheimer	activates	disease	0.65
Neuroblastoma	causes	disease	0.65
Alzheimer	causes	disease	0.65
ACETYLCHOLINE	activates	phenotype	0.65
Als	regulates	disease	0.65
Als	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Dementia	interacts_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Stroke	biomarker_for	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Heart Failure	biomarker_for	disease	0.65
Vascular Dementia	transports	disease	0.65
Als	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Diabetes	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
NEURON	associated_with	gene	0.65
Ms	associated_with	disease	0.65
Amyloid	transports	protein	0.60
ENDOTHELIAL	interacts_with	cell_type	0.60
PERICYTE	interacts_with	cell_type	0.60
PERICYTES	interacts_with	cell_type	0.60
ENDOTHELIAL	causes	cell_type	0.60
CYP3A5	regulates	gene	0.60

Incoming (125)

Source	Relation	Type	Str
h-7110565d	targets	hypothesis	0.90
Pterostilbene	upregulates	compound	0.90
BDNF	protects_against	gene	0.70
ALZHEIMER	associated_with	gene	0.70
ACHE	associated_with	gene	0.70
NEURONS	regulates	cell_type	0.65
APOE	co_discussed	gene	0.60
CYTOKINES	expressed_in	gene	0.60
AND	activates	gene	0.60
APOE	activates	gene	0.60
APP	activates	gene	0.60
BACE2	activates	gene	0.60
CD38	activates	gene	0.60
ASTROCYTE	activates	cell_type	0.60
BDNF	markers	gene	0.60
CAT	regulates	gene	0.60
AKT	activates	gene	0.60
CYP3A5	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
ACHE	expressed_in	gene	0.60
ASTROCYTES	implicated_in	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
ACHE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURON	activates	gene	0.60
APP/PS1	transports	gene	0.60
CYP3A5	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
APP/PS1	associated_with	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
NR1I2	therapeutic_target	gene	0.60
ALZHEIMER	interacts_with	disease	0.60
ALZHEIMER'S	interacts_with	disease	0.60
ALZHEIMER'S DISEASE	interacts_with	disease	0.60
ALZHEIMER'S	causes	disease	0.60
B CELL	activates	cell_type	0.60
ACHE	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ABCB1	therapeutic_target	gene	0.60
NLRP3	protects_against	gene	0.60
BDNF	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
ALZHEIMER	co_discussed	gene	0.60
ANXIETY	co_discussed	gene	0.60
ACETYL-COA	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
POR	therapeutic_target	gene	0.60
ACHE	markers	gene	0.60
AD	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sensory-Motor Circuit Cross-Modal Compensation	0.546	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 67 hypotheses Top: 1.000

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Electroacupuncture ST37 treatment for DSS-induced colitis in mice	validation	colitis	0.950	0.00	mice	proposed	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026
Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides [PMID:41547348]	Jia Y, Chen H, Zou Q, Chen S, Li J et al	Neuron	2026
Carnitine acetyltransferase acts as a unidirectional compensatory enzyme for cho [PMID:41629006]	Zhang Z, Wang J, He T, Hu T, Wu X et al.	Pestic Biochem Physiol	2026
Nanogel Delivery of Plumbagin from Nepenthes Khasiana Attenuates Neuroinflammati [PMID:41653259]	Zhang X, Zhang X	Appl Biochem Biotechnol	2026
Targeting cholinergic cells in a mouse model of Alzheimer's disease: Validating [PMID:41679590]	Farkas S, Jasper V, Nyers-Marosi K, Petr	Exp Neurol	2026
Lymphocyte-derived cholinergic circuits modulate germinal center output and B ce [PMID:41735533]	Nechanitzky D, Smith LK, Nechanitzky R,	Nat Immunol	2026
Selective genetic targeting of the mouse efferent vestibular nucleus identifies [PMID:41770522]	Mathews MA, Tung VWK, Reader-Harris EC,	J Neurophysiol	2026
Electroacupuncture Attenuates Colitis in Mice Through Activation of Vagus Cholin [PMID:41847427]	Qu Z, Luo M, Liu X, Su Y, Jing X	J Inflamm Res	2026
Hippocampal BiP Overexpression Rescues Cognitive Performance and Increases REM t [PMID:41928945]	Duncan WE, Fenik P, Strus E, Veasey S, N	bioRxiv	2026
A compound pulsed magnetic field achieves superior cognitive benefits against Al [PMID:41856031]	Wang X, Wang X, Zhao H, Zhao C, Wang P,	Neurotherapeutics : the journa	2026

Debates (1)

Multi-agent debates referencing this entity

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CHAT in their description or question text

No additional research found