concept

PERICYTE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERICYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

855Connections

13Hypotheses

0Analyses

50Outgoing

50Incoming

4Experiments

0Debates

Summary

PERICYTE is a concept in neurodegeneration research. Key relationships include: activates, co discussed, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 128 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PERICYTE
Key Genes/Proteins	ACHE, AD, AKT, Albumin, ALDH2, AMPK
Related Diseases	Aging, Als, ALS, Alzheimer, ALZHEIMER
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Pericyte PDGFR-Beta Agonist for Neurovascular Rescue

idea · 1751 words

→

Pathway Diagram

graph TD
    PERICYTE["PERICYTE"]
    PERICYTE -->|"activates"| ALS["ALS"]
    PERICYTE -->|"contributes to"| Aging["Aging"]
    PERICYTE -->|"causes"| Alzheimer["Alzheimer"]
    PERICYTE -->|"contributes to"| Huntington["Huntington"]
    PERICYTE -->|"contributes to"| Dementia["Dementia"]
    PERICYTE -->|"activates"| CYTOKINES["CYTOKINES"]
    PERICYTE -->|"interacts"| ANGPT1["ANGPT1"]
    PERICYTE -->|"interacts"| Pi3K_Akt["Pi3K/Akt"]
    PERICYTE -->|"activates"| Glycolysis["Glycolysis"]
    CD36["CD36"] -->|"regulates"| PERICYTE
    PI3K["PI3K"] -->|"interacts"| PERICYTE
    AKT["AKT"] -->|"interacts"| PERICYTE
    AMYLOID["AMYLOID"] -->|"activates"| PERICYTE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| PERICYTE
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"contributes to"| PERICYTE
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO["BLOOD-BRAIN BARRIER DYSFUNCTION"] -->|"contributes to"| PERICYTE
    APOE4["APOE4"] -->|"activates"| PERICYTE
    ALZHEIMER["ALZHEIMER"] -->|"causes"| PERICYTE

Outgoing (292)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.75
myofibroblast	involved_in	cell_type	0.75
PERICYTES	targets	cell_type	0.70
RAGE	activates	gene	0.70
TAU	markers	gene	0.70
RAGE	markers	gene	0.70
RAGE	associated_with	gene	0.70
PERICYTES	expressed_in	cell_type	0.70
PERICYTES	degrades	cell_type	0.70
PERICYTES	enhances	cell_type	0.70
AMYLOID	activates	gene	0.70
ENDOTHELIAL CELLS	interacts_with	cell_type	0.70
AMYLOID-BETA	destabilizes	protein	0.70
AMYLOID-BETA	causes	protein	0.70
SPINAL CORD	activates	brain_region	0.70
SPINAL CORD	causes	brain_region	0.70
AMYLOID	destabilizes	protein	0.70
COGNITIVE DECLINE	protects_against	phenotype	0.70
COGNITIVE DECLINE	stabilizes	phenotype	0.70
ALZHEIMER'S DISEASE	associated_with	disease	0.70
ENDOTHELIAL CELLS	produces	cell_type	0.70
CEREBRAL AMYLOID ANGIOPATHY	activates	disease	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
Alzheimer	causes	disease	0.65
Huntington	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
MAPK	regulates	gene	0.65
MACROPHAGE	activates	cell_type	0.65
Als	activates	disease	0.65
NEURODEGENERATION	causes	disease	0.65
Dementia	contributes_to	disease	0.65
APOPTOSIS	inhibits	phenotype	0.65
APOPTOSIS	activates	phenotype	0.65
VEGF	activates	gene	0.65
AUTOPHAGY	inhibits	phenotype	0.65
Stroke	regulates	disease	0.65
Stroke	inhibits	disease	0.65
Ferroptosis	expressed_in	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Coronary Artery Disease	associated_with	disease	0.65
PERICYTES	activates	cell_type	0.65
Alzheimer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Senescence	activates	disease	0.65
AKT	regulates	gene	0.65
TNF	produces	gene	0.65
Cancer	activates	disease	0.65

Incoming (563)

Source	Relation	Type	Str
ABCC8	expressed_in	gene	0.80
OLIGODENDROCYTE	disrupts	cell_type	0.70
ENDOTHELIAL	disrupts	cell_type	0.70
MICROGLIA	causes	cell_type	0.70
ENDOTHELIAL	associated_with	cell_type	0.70
NEURONS	disrupts	cell_type	0.70
LRRK2	associated_with	gene	0.70
MICROGLIA	disrupts	cell_type	0.70
PDGF	biomarker_for	gene	0.70
PDGF	associated_with	gene	0.70
OLIGODENDROCYTES	disrupts	cell_type	0.70
ASTROCYTE	mediates	cell_type	0.70
OLIGODENDROCYTES	inhibits	cell_type	0.70
OLIGODENDROCYTE	inhibits	cell_type	0.70
ASTROCYTE	causes	cell_type	0.70
NEURONS	mediates	cell_type	0.70
NEURONS	interacts_with	cell_type	0.70
NEURONS	activates	cell_type	0.70
HUNTINGTON'S DISEASE	interacts_with	disease	0.70
ENDOTHELIAL	activates	cell_type	0.70
APOE	disrupts	gene	0.70
ENDOTHELIAL	markers	cell_type	0.70
NEURONS	expresses	cell_type	0.70
MICROGLIA	interacts_with	cell_type	0.70
ENDOTHELIAL	targets	cell_type	0.70
MACROPHAGE	activates	cell_type	0.70
ASTROCYTE	targets	cell_type	0.70
NEURONS	enhances	cell_type	0.70
ENDOTHELIAL	interacts_with	cell_type	0.70
MICROGLIA	expresses	cell_type	0.70
NEURONS	targets	cell_type	0.70
AMPK	regulates	gene	0.70
CREB	activates	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
CD36	activates	protein	0.70
APP	regulates	gene	0.70
OXIDATIVE STRESS	activates	phenotype	0.70
PDGF	treats	gene	0.70
CD36	regulates	protein	0.70
SPINAL CORD	inhibits	brain_region	0.70
PDGF	enhances	gene	0.70
PDGF	regulates	gene	0.70
PDGF	causes	gene	0.70
NEURODEGENERATION	activates	gene	0.70
apoptosis	co_discussed	concept	0.65
NEURONS	regulates	cell_type	0.65
NEURON	regulates	cell_type	0.65
ALZHEIMER	stabilizes	disease	0.65
APOE	stabilizes	gene	0.65
APOE4	stabilizes	gene	0.65

Targeting Hypotheses (13)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-driven pericyte injury/senescence is an upstream drive	0.720	neurodegeneration	Does pericyte senescence drive BBB break
Pericyte-targeted senolysis or senomorphic therapy will bene	0.700	neurodegeneration	Does pericyte senescence drive BBB break
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.684	neurodegeneration	Perivascular spaces and glymphatic clear
Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-	0.662	-	Blood-brain barrier permeability changes
Radiation drives pericyte senescence through lysosome acidif	0.652	neurodegeneration	What specific autophagy pathways are def

Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break
Pericyte senescence is sufficient to weaken the BBB even wit	0.630	neurodegeneration	Does pericyte senescence drive BBB break
Chronic mTORC1-ULK1 signaling blocks autophagy initiation in	0.578	neurodegeneration	What specific autophagy pathways are def
BBB leak induces secondary pericyte senescence through TGF-b	0.560	neurodegeneration	Does pericyte senescence drive BBB break
Loss of pericyte-derived pleiotrophin is a key disease-modif	0.510	neurodegeneration	Does pericyte senescence drive BBB break
GluN2B-Mediated Perivascular Pericyte Control of Glymphatic	0.485	neuroscience	Circuit-level neural dynamics in neurode
Cerebral VSMC foam cells induce pericyte detachment via PDGF	0.473	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
HBOT at 1.5 ATA for 90 days restores BBB integrity by upregu	0.460	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Irisin effects on angiogenesis in human endothelial cells	exploratory	bone fracture	0.900	0.00	human umbilical vein endotheli	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726]	Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu	Cell Stem Cell	2025	1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043]	Kempuraj D, Dourvetakis KD, Cohen J, Val	Front Cell Neurosci	2024	1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066]	Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T	Int J Mol Sci	2023	1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333]	Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z	Nature	2021	1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954]	Montagne A, Nation DA, Sagare AP, Barisa	Nature	2020	1
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026	0
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033]	Levey J, Howe M, Douglas K, Odame E, Raj	bioRxiv : the preprint server	2026	0
Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335]	Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha	Research (Washington, D.C.)	2026	0
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129]	Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu	Clinical & experimental ophtha	2026	0
Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656]	Jansson D, Highet B, Li S, Stevenson TJ,	Molecular brain	2026	0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
The role of endothelial cell-pericyte interactions in vascularization and diseas [PMID:38246244]	Li G, Gao J, Ding P, Gao Y	Journal of advanced research	2025	0
Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions. [PMID:41351407]	Drozd U, Vechkapova S, Lanshakov D	Frontiers in bioscience (Landm	2025	0
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	0
Pericyte-derived fibrotic scarring is conserved across diverse central nervous s [PMID:34535655]	Dias DO, Kalkitsas J, Kelahmetoglu Y, Es	Nature communications	2021	0
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfuncti [PMID:30643288]	Nation DA, Sweeney MD, Montagne A, Sagar	Nature medicine	2019	0
Pericytes in Primary Familial Brain Calcification. [PMID:31147881]	Zarb Y, Franzoso FD, Keller A	Advances in experimental medic	2019	0
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. [PMID:29502968]	Dias DO, Kim H, Holl D, Werne Solnestam	Cell	2018	0
Clarifying off-target effects for torcetrapib using network pharmacology and rev [PMID:23228038]	["Fan S", "Geng Q", "Pan Z", "Li X", "Ti	BMC systems biology	2012	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PERICYTE in their description or question text

PERICYTE

Understanding Entity Pages

Summary

Wiki Pages (1)

Pericyte PDGFR-Beta Agonist for Neurovascular Rescue

Pathway Diagram

Outgoing (292)

Incoming (563)

Targeting Hypotheses (13)

Mentioning Analyses (0)

Experiments (4)

Related Papers (20)

Debates (0)

Related Research

Amyloid-beta induces secondary pericyte senescence after contractile and oxidati

Pericyte senescence is sufficient to weaken the BBB even without classic amyloid

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericyte

BBB leak induces secondary pericyte senescence through TGF-beta-dominant stress

Loss of pericyte-derived pleiotrophin is a key disease-modifying consequence of

GluN2B-Mediated Perivascular Pericyte Control of Glymphatic Tau Clearance

Cerebral VSMC foam cells induce pericyte detachment via PDGF-BB/VEGF imbalance,

HBOT at 1.5 ATA for 90 days restores BBB integrity by upregulating claudin-5 and