gene

RAB7L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB7L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

50Outgoing

9Incoming

0Experiments

0Debates

Summary

RAB7L1 is a Rab GTPase involved in late endosomal/lysosomal trafficking, implicated in Parkinson's disease risk through GWAS and LRRK2 interaction.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RAB7L1
Full Name	RAB7 Like 1
Chromosome	9q31.3
Function	is a member of the Rab GTPase family that plays critical roles in late endosomal and lysosomal trafficking pathways.
Primary Expression	Brain, heart, kidney, liver
Subcellular Localization	through geranylgeranyl lipid modification
Molecular Weight	21 kDa
Amino Acids	183 aa
Exons	7
Pathways	Vesicle Trafficking
UniProt ID	Q9BY66
NCBI Gene ID	57171
Ensembl ID	ENSG00000142530
OMIM	614930
GeneCards	RAB7L1
Human Protein Atlas	RAB7L1
Associated Diseases	ALS, dementia, frontotemporal
Interactions	AND, ARHGEF7, AUTOPHAGY, C9ORF72, CDC42, GAIN
KG Connections	60 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB7L1 — AlphaFold Q9BY66 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAB7L1 (RAB7 Like 1)

gene · 1823 words

→

RAB7L1 Protein

protein · 682 words

→

Pathway Diagram

graph TD
    RAB7L1["RAB7L1"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    RAB7L1 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    RAB7L1 -->|"activates"| Ms
    Dementia{"Dementia"}
    RAB7L1 -->|"regulates"| Dementia
    Als{"Als"}
    RAB7L1 -->|"activates"| Als
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    RAB7L1 -->|"regulates"| Frontotemporal_Dementia
    Ftd{"Ftd"}
    RAB7L1 -->|"activates"| Ftd
    Neuroblastoma{"Neuroblastoma"}
    RAB7L1 -->|"interacts with"| Neuroblastoma
    Parkinson{"Parkinson"}
    RAB7L1 -->|"interacts with"| Parkinson
    RAB7L1 -->|"interacts with"| Ms
    RAB7L1 -->|"inhibits"| Ms
    ALS{"ALS"}
    RAB7L1 -->|"activates"| ALS
    GAIN["GAIN"]
    RAB7L1 -->|"activates"| GAIN
    GAIN -->|"activates"| RAB7L1
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"regulates"| RAB7L1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RAB7L1
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"transports"| RAB7L1
    GAIN -->|"transports"| RAB7L1
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"]
    VESICLE_TRAFFICKING -->|"regulates"| RAB7L1
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"regulates"| RAB7L1
    AND["AND"]
    AND -->|"activates"| RAB7L1
    style RAB7L1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

Target	Relation	Type	Str
Vesicle Trafficking	regulates	process	0.95
ALS	activates	disease	0.65
Ms	inhibits	disease	0.65
Neuroblastoma	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	activates	disease	0.65
Dementia	regulates	disease	0.65
Als	activates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Ftd	activates	disease	0.65
Raf	regulates	protein	0.60
DEMENTIA	regulates	gene	0.60
GAIN	transports	gene	0.60
C9ORF72	regulates	gene	0.60
frontotemporal	associated_with	disease	0.60
AUTOPHAGY	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
MOTOR NEURONS	transports	gene	0.60
VESICLE TRAFFICKING	regulates	gene	0.60
Neuron	activates	cell_type	0.60
MAPK	interacts_with	gene	0.60
Stem Cell	activates	cell_type	0.60
Fibroblast	activates	cell_type	0.60
dementia	associated_with	disease	0.60
GAIN	activates	gene	0.60
ARHGEF7	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
RGS2	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
RAB5	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
AND	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
AND	activates	gene	0.60
ALS	associated_with	disease	0.60
Stem Cell	expressed_in	cell_type	0.55
Fibroblast	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
FIBROBLASTS	activates	concept	0.50
FRONTOTEMPORAL	regulates	concept	0.50
disease	interacts_with	disease	0.50
C9ORF72	activates	gene	0.50
FRONTOTEMPORAL DEMENTIA	regulates	disease	0.50
amyotrophic lateral sclerosis	regulates	gene	0.50
C9ORF72	interacts_with	gene	0.50
VESICLE TRAFFICKING	interacts_with	concept	0.50

Incoming (9)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
C9ORF72	interacts_with	entity	0.60
MOTOR NEURONS	transports	gene	0.60
VESICLE TRAFFICKING	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
GAIN	activates	gene	0.60
C9ORF72	regulates	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
GAIN	transports	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB7L1 in their description or question text

No additional research found