gene

PLIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

35Outgoing

5Incoming

0Experiments

0Debates

Summary

Comprehensive gene page for PLIN1 (Perilipin 1), a critical lipid droplet-associated protein that regulates lipid storage, lipolysis, and cellular energy metabolism. PLIN1 dysfunction contributes to metabolic disorders and neurodegenerative diseases through lipid dysregulation, oxidative stress, and neuroinflammation.

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🧬 Gene Info

Gene Symbol	PLIN1
Full Name	Perilipin 1
Chromosome	15q26.1
Protein Family	Perilipin family (PLIN1, PLIN2, PLIN3, PLIN4, PLIN5)
Function	is a peripheral membrane protein that associates with the phospholipid monolayer that surrounds neutral lipid droplets.
Primary Expression	adipocytes, where it plays an essential role in regulating lipid storage and mobilization by protecting stored triglycerides from lipolytic enzymes an
Molecular Weight	56 kDa
Amino Acids	522 aa
Pathways	Apoptosis, Autophagy, Pi3K/Akt
UniProt ID	Q13441 (PLIN1_HUMAN)
NCBI Gene ID	5346
Ensembl ID	ENSG00000141579
OMIM	170650
GeneCards	PLIN1
Human Protein Atlas	PLIN1
Associated Diseases	Aging, Ms
Interactions	ABCG1, GLUT4, MFN1, MFN2, PARP1, PPARG
KG Connections	40 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLIN1 — AlphaFold Q13441 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLIN1 — Perilipin 1

gene · 2940 words

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Pathway Diagram

graph TD
    PLIN1["PLIN1"]
    Aging{"Aging"}
    PLIN1 -->|"associated with"| Aging
    Ms{"Ms"}
    PLIN1 -->|"associated with"| Ms
    PLIN1 -->|"expressed in"| Ms
    Tumor{"Tumor"}
    PLIN1 -->|"expressed in"| Tumor
    Als{"Als"}
    PLIN1 -->|"activates"| Als
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    PLIN1 -->|"associated with"| MITOCHONDRIAL_DYSFUNCTION
    HSP90AB1["HSP90AB1"]
    PLIN1 -->|"associated with"| HSP90AB1
    AUTOPHAGY["AUTOPHAGY"]
    PLIN1 -->|"associated with"| AUTOPHAGY
    MAP1LC3B["MAP1LC3B"]
    PLIN1 -->|"associated with"| MAP1LC3B
    Lipid_Metabolism(["Lipid Metabolism"])
    PLIN1 -->|"associated with"| Lipid_Metabolism
    Autophagy(["Autophagy"])
    PLIN1 -->|"associated with"| Autophagy
    IGF1["IGF1"]
    PLIN1 -->|"expressed in"| IGF1
    AGING["AGING"]
    AGING -->|"associated with"| PLIN1
    style PLIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

Target	Relation	Type	Str
Tumor	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Pi3K/Akt	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
IGF1	expressed_in	gene	0.60
P2RY14	expressed_in	gene	0.60
MMP9	expressed_in	gene	0.60
FOS	expressed_in	gene	0.60
TAC1	expressed_in	gene	0.60
SPP1	expressed_in	gene	0.60
HSP90AB1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
AUTOPHAGY	associated_with	gene	0.60
GLUT4	activates	gene	0.60
MFN1	activates	gene	0.60
MFN2	activates	gene	0.60
PPARG	activates	gene	0.60
PI3K	regulates	gene	0.60
APOE	regulates	gene	0.60
ABCG1	inhibits	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
AKT	regulates	gene	0.60
CHONDROCYTE APOPTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
AGING	associated_with	gene	0.60
PARP1	inhibits	gene	0.60
ABCG1	inhibits	gene	0.60
ABCG1	activates	gene	0.60
PARP1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLIN1 in their description or question text

No additional research found