gene

ZAP70

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZAP70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

32Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for ZAP70 — Zeta Chain T-Cell Receptor Associated Protein Kinase 70

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🧬 Gene Info

Gene Symbol	ZAP70
Full Name	Zeta Chain T-Cell Receptor Associated Protein Kinase 70
Chromosome	2q11.82
Protein Type	Kinase
Function	is a tyrosine kinase essential for T-cell receptor (TCR) signaling and adaptive immunity.
Ensembl ID	ENSG00000120217
GeneCards	ZAP70
Human Protein Atlas	ZAP70
N-terminal tandem SH2 domains	Bind to phosphorylated ITAM motifs on TCR ζ-chain
Interdomain A	Regulatory region
Kinase domain	Catalytic activity (C-terminal)
C-terminal proline-rich region	Protein-protein interactions
LAT	Linker for activation of T cells
SLP-76	Adapter protein
Vav	GEF for Rho family GTPases
Associated Diseases	neurodegeneration
Interactions	ACTB, CAT, CCL5, CD19, CD4, CDK4
KG Connections	39 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ZAP70 — Zeta Chain T-Cell Receptor Associated Protein Kinase 70

gene · 515 words

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Pathway Diagram

graph TD
    ZAP70["ZAP70"]
    Ms{"Ms"}
    ZAP70 -->|"regulates"| Ms
    Autism{"Autism"}
    ZAP70 -->|"regulates"| Autism
    Cardiovascular{"Cardiovascular"}
    ZAP70 -->|"biomarker for"| Cardiovascular
    Atherosclerosis{"Atherosclerosis"}
    ZAP70 -->|"biomarker for"| Atherosclerosis
    Diabetes{"Diabetes"}
    ZAP70 -->|"biomarker for"| Diabetes
    Als{"Als"}
    ZAP70 -->|"biomarker for"| Als
    ZAP70 -->|"biomarker for"| Ms
    TP53["TP53"]
    ZAP70 -->|"interacts with"| TP53
    MIRNAS["MIRNAS"]
    ZAP70 -->|"regulates"| MIRNAS
    CD19["CD19"]
    ZAP70 -->|"interacts with"| CD19
    EEF2["EEF2"]
    ZAP70 -->|"interacts with"| EEF2
    CCL5["CCL5"]
    ZAP70 -->|"interacts with"| CCL5
    CD4["CD4"]
    CD4 -->|"interacts with"| ZAP70
    MAPK3["MAPK3"]
    MAPK3 -->|"interacts with"| ZAP70
    CD4 -->|"biomarker for"| ZAP70
    style ZAP70 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
Ms	regulates	disease	0.65
Autism	regulates	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Cardiovascular	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
TLR7	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
RAC2	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
CDKN1A	interacts_with	gene	0.60
LCK	interacts_with	gene	0.60
MFN1	biomarker_for	gene	0.60
JAK3	biomarker_for	gene	0.60
DIABETES MELLITUS	biomarker_for	gene	0.60
IMMUNE INFILTRATION	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
Apoptosis	biomarker_for	pathway	0.60
TP53	interacts_with	gene	0.60
Tgf-Β	biomarker_for	pathway	0.60
CD19	interacts_with	gene	0.60
EEF2	interacts_with	gene	0.60
CCL5	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
MIRNAS	regulates	gene	0.60
Mapk	interacts_with	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
CRISPR-Cas	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60

Incoming (7)

Source	Relation	Type	Str
SYK	activates	gene	0.60
SYK	regulates	gene	0.60
SYK	associated_with	gene	0.60
CD19	activates	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
CD4	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ZAP70 in their description or question text

No additional research found