concept

PM10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

12Outgoing

1Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PM10
Key Genes/Proteins	COX4I1, DRP1, FIS1, MFN1, OPA1, PGC-1Α
Related Diseases	mitochondrial dysfunction, Mitochondrial Dysfunction

Pathway Diagram

graph TD
    PM10[PM10]
    PM10 -->|causes| mitochondrial_dysfunction[mitochondrial dysfunction]
    PM10 -->|causes| Oxidative_Stress[Oxidative Stress]
    PM10 -->|causes| Mitochondrial_Dysfunction[Mitochondrial Dysfunction]
    PM10 -->|causes| oxidative_stress[oxidative stress]
    PM10 -->|downregulates| MFN1[MFN1]
    PM10 -->|downregulates| OPA1[OPA1]
    PM10 -->|upregulates| DRP1[DRP1]
    PM10 -->|upregulates| FIS1[FIS1]
    PM10 -->|downregulates| COX4I1[COX4I1]
    PM10 -->|downregulates| TFAM[TFAM]
    SKQ1[SKQ1] -.protects against.-> PM10

Outgoing (12)

Target	Relation	Type	Str
mitochondrial dysfunction	causes	phenotype	0.95
Oxidative Stress	causes	process	0.95
Mitochondrial Dysfunction	causes	phenotype	0.95
oxidative stress	causes	process	0.90
MFN1	downregulates	gene	0.85
OPA1	downregulates	gene	0.85
DRP1	upregulates	gene	0.85
FIS1	upregulates	gene	0.85
COX4I1	downregulates	gene	0.85
TFAM	downregulates	gene	0.80
SOD2	downregulates	gene	0.80
PGC-1Α	downregulates	gene	0.80

Incoming (1)

Source	Relation	Type	Str
SKQ1	protects_against	drug	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PM10 in their description or question text

No additional research found