protein

GSDMD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSDMD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

859Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

GSDMD is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 220 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	GSDMD
Function	is a gene encoding a key executor of pyroptotic cell death
Primary Expression	hippocampus, temporal lobe, cortex, Substantia Nigra, Ca1
Molecular Weight	56 kDa
Amino Acids	484 aa
Pathways	Apoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress
GeneCards	GSDMD
Human Protein Atlas	GSDMD
Associated Diseases	Als, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis, autism
Known Drugs/Compounds	curcumin, natural products, Pterostilbene, Qingqi Liangying Formula, XHP
Interactions	ABCG2, ACSL4, Actin, AGING, AIF, AIM2
KG Connections	859 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSDMD["GSDMD"]
    GSDMD -->|"activates"| pyroptosis["pyroptosis"]
    GSDMD -->|"inhibits"| Inflammation["Inflammation"]
    GSDMD -->|"inhibits"| Hepatitis["Hepatitis"]
    GSDMD -->|"inhibits"| Fibrosis["Fibrosis"]
    GSDMD -->|"activates"| Als["Als"]
    GSDMD -->|"activates"| Parkinson["Parkinson"]
    GSDMD -->|"activates"| Stroke["Stroke"]
    GSDMD -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GSDMD -->|"activates"| Ms["Ms"]
    NLRP3["NLRP3"] -->|"activates"| GSDMD
    PYROPTOSIS["PYROPTOSIS"] -->|"regulates"| GSDMD
    FASN["FASN"] -->|"inhibits"| GSDMD
    BAX["BAX"] -->|"inhibits"| GSDMD
    ALOX15["ALOX15"] -->|"inhibits"| GSDMD
    POLE["POLE"] -->|"activates"| GSDMD
    TREM2["TREM2"] -->|"activates"| GSDMD
    TLR4["TLR4"] -->|"activates"| GSDMD
    ACSL4["ACSL4"] -->|"inhibits"| GSDMD
    TNF["TNF"] -->|"inhibits"| GSDMD

Outgoing (576)

Target	Relation	Type	Str
Astrocytic Pyroptosis	mediates	process	0.95
pyroptosis	associated_with	process	0.95
Pyroptosis	mediates	process	0.95
microglial pyroptosis	promotes	process	0.95
pyroptosis	mediates	process	0.95
neurodegeneration	associated_with	process	0.90
Fibrosis	contributes_to	disease	0.90
Membrane Rupture	mediates	process	0.90
Microglial Pyroptosis	mediates	process	0.90
pyroptosis	participates_in	pathway	0.90
autism spectrum disorder	interacts_with	disease	0.90
Depression	involved_in	disease	0.85
Inflammation	activates	disease	0.85
Pyroptosis	associated_with	process	0.85
autism	activates	disease	0.80
pyroptosis	inhibits	process	0.80
oxidative stress response	participates_in	pathway	0.80
microglia	expressed_in	cell_type	0.80
Alzheimer's disease	implicated_in	disease	0.80
autism	inhibits	disease	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
autism	regulates	disease	0.80
unfolded protein response	participates_in	pathway	0.80
autism spectrum disorder	activates	disease	0.80
NLRP3	activates	gene	0.80
Pyroptosis	inhibits	pathway	0.80
ROS	activates	gene	0.80
Neurodegeneration	activates	disease	0.75
Als	activates	disease	0.75
Neuroinflammation	activates	disease	0.75
NLRP3	inhibits	gene	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
microglia	activates	cell_type	0.70
microglia	regulates	cell_type	0.70
microglia	inhibits	cell_type	0.70
NEUROINFLAMMATION	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
MTDNA	activates	gene	0.70
Alzheimer's disease	regulates	disease	0.70
microglia	degrades	cell_type	0.70
Nf-Κb	activates	pathway	0.70
PYROPTOSIS	inhibits	gene	0.70
NEUROTOXICITY	activates	gene	0.70
Ferroptosis	inhibits	pathway	0.70
NEURODEGENERATION	activates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
Pyroptosis	activates	pathway	0.70
neuroinflammation	interacts_with	disease	0.70
autism	degrades	disease	0.70

Incoming (283)

Source	Relation	Type	Str
XHP	activates	drug	0.95
Qingqi Liangying Formula	inhibits	drug	0.95
caspase-1	cleaves	protein	0.95
CASP1	activates	gene	0.95
Microglia	expressed_in	cell_type	0.90
Astrocytes	expressed_in	cell_type	0.90
Neuron	expressed_in	cell_type	0.90
CASP1	associated_with	protein	0.90
Pterostilbene	inhibits	compound	0.90
NLRP3	activates	gene	0.90
CASP1	phosphorylates	protein	0.90
NLRP3 inflammasome	activates	protein	0.90
TLR2	upregulates	gene	0.90
Aucubin	downregulates	compound	0.89
NLRP3	associated_with	protein	0.88
Tlr2 Inhibition	suppresses	mechanism	0.85
natural products	targets	compound	0.75
ACSL4	inhibits	gene	0.70
PYROPTOSIS	regulates	pathway	0.64
PARKINSON'S DISEASE	causes	gene	0.60
DNA	regulates	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
ROS	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
GASDERMIN	causes	gene	0.60
GPR109A	inhibits	gene	0.60
ASC	associated_with	gene	0.60
TNF	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
ZBP1	inhibits	gene	0.60
VDAC1	activates	gene	0.60
CAT	activates	gene	0.60
NLRP3	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
P38	inhibits	gene	0.60
ATG5	activates	gene	0.60
STING	activates	gene	0.60
JAK2	activates	gene	0.60
STAT3	activates	gene	0.60
HMGB1	activates	gene	0.60
GSDME	activates	gene	0.60
OVERVIEW	regulates	gene	0.60
GSDME	associated_with	gene	0.60
NEK7	activates	gene	0.60
RELA	activates	gene	0.60
BAX	phosphorylates	entity	0.60
RIPK1	regulates	gene	0.60
ASC	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.732

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning GSDMD in their description or question text

No additional research found

GSDMD

Understanding Entity Pages

Summary

Wiki Pages (3)

Gasdermin D Protein

GSDMD Protein

GSDMD Gene

Pathway Diagram

Outgoing (576)

Incoming (283)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Synaptic pruning by microglia in early AD

4R-tau strain-specific spreading patterns in PSP vs CBD

Experiments (0)

Related Papers (0)

Debates (3)

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

Synaptic pruning by microglia in early AD

Related Research