protein

CASPASE-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Caspase-1 is an inflammatory caspase that executes pyroptosis and processes pro-inflammatory cytokines. It plays critical roles in neuroinflammation and is implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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🔬 Protein Info

Gene Symbol	CASPASE
GeneCards	CASPASE
Human Protein Atlas	CASPASE
Associated Diseases	ferroptosis
Interactions	ALZHEIMER, AMYLOID, BCL-XL, DRD2, GASDERMIN, GASDERMIN D
KG Connections	99 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-1 Protein

redirect · 625 words

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Pathway Diagram

graph TD
    CASPASE_1["CASPASE-1"]
    A1_Inductor_Secretion["A1 Inductor Secretion"]
    CASPASE_1 -->|"catalyzes"| A1_Inductor_Secretion
    A1_Inductor_Secretion["A1 Inductor Secretion"]
    CASPASE_1 -->|"mediates"| A1_Inductor_Secretion
    NLRP3["NLRP3"]
    NLRP3 -->|"activates"| CASPASE_1
    IL_18["IL-18"]
    CASPASE_1 -->|"co discussed"| IL_18
    IL_1_["IL-1Beta"]
    CASPASE_1 -->|"co discussed"| IL_1_
    NLRP3["NLRP3"]
    CASPASE_1 -->|"co discussed"| NLRP3
    WAS["WAS"]
    CASPASE_1 -->|"co discussed"| WAS
    ISCHEMIA["ISCHEMIA"]
    CASPASE_1 -->|"activates"| ISCHEMIA
    INFLAMMASOME["INFLAMMASOME"]
    CASPASE_1 -->|"activates"| INFLAMMASOME
    Astrocytes["Astrocytes"]
    CASPASE_1 -->|"activates"| Astrocytes
    BCL_XL["BCL-XL"]
    CASPASE_1 -->|"inhibits"| BCL_XL
    apoptosis["apoptosis"]
    CASPASE_1 -->|"inhibits"| apoptosis
    Pyroptosis["Pyroptosis"]
    CASPASE_1 -->|"inhibits"| Pyroptosis
    Necroptosis["Necroptosis"]
    CASPASE_1 -->|"inhibits"| Necroptosis
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    CASPASE_1 -->|"activates"| Nlrp3_Inflammasome
    HO_1["HO-1"]
    CASPASE_1 -->|"activates"| HO_1
    TNF__["TNF-alpha"]
    CASPASE_1 -->|"activates"| TNF__
    NF__B["NF-kappaB"]
    CASPASE_1 -->|"activates"| NF__B
    Astrocyte["Astrocyte"]
    CASPASE_1 -->|"activates"| Astrocyte
    Neuroinflammatory["Neuroinflammatory"]
    CASPASE_1 -->|"activates"| Neuroinflammatory
    NF__B["NF-kappaB"]
    CASPASE_1 -->|"inhibits"| NF__B
    TNF__["TNF-alpha"]
    CASPASE_1 -->|"inhibits"| TNF__
    Proteins["Proteins"]
    CASPASE_1 -->|"inhibits"| Proteins
    INFLAMMASOME["INFLAMMASOME"]
    CASPASE_1 -->|"associated with"| INFLAMMASOME
    INFLAMMASOME["INFLAMMASOME"]
    CASPASE_1 -->|"expressed in"| INFLAMMASOME
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    CASPASE_1 -->|"expressed in"| Nlrp3_Inflammasome
    Proteins["Proteins"]
    CASPASE_1 -->|"expressed in"| Proteins
    inflammation["inflammation"]
    CASPASE_1 -->|"activates"| inflammation
    ALZHEIMER["ALZHEIMER"]
    CASPASE_1 -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    CASPASE_1 -->|"activates"| Alzheimer_S_Disease

Outgoing (60)

Target	Relation	Type	Str
GSDMD	cleaves	protein	0.95
IL-1 Cytokine Release	mediates	process	0.90
IL1B	cleaves	protein	0.90
IL1B Maturation	activates	process	0.90
Interleukin-1β	activates	protein	0.90
Interleukin-18	activates	protein	0.90
APOPTOSIS	mediates	process	0.80
IL-1β	activates	protein	0.70
inflammation	associated_with	pathway	0.50
MAPK	associated_with	gene	0.50
NF-κB	associated_with	concept	0.50
CYTOKINES	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
CYTOKINES	regulates	concept	0.50
Cortex	regulates	brain_region	0.50
Nlrp3 Inflammasome	regulates	pathway	0.50
IL-1	regulates	concept	0.50
ferroptosis	associated_with	phenotype	0.50
Pyroptosis	associated_with	pathway	0.50
GASDERMIN	associated_with	gene	0.50
NF-κB	activates	concept	0.50
Astrocyte	activates	cell_type	0.50
Neuroinflammatory	activates	pathway	0.50
NF-κB	inhibits	concept	0.50
TNF-α	inhibits	concept	0.50
Nlrp3 Inflammasome	expressed_in	pathway	0.50
Proteins	expressed_in	protein	0.50
inflammation	activates	pathway	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
CYTOKINES	activates	concept	0.50
Pyroptosis	activates	pathway	0.50
PROINFLAMMATORY CYTOKINES	activates	concept	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
GASDERMIN	activates	gene	0.50
apoptosis	interacts_with	process	0.50
Substantia Nigra	interacts_with	entity	0.50
CELL DEATH	activates	concept	0.50
inflammation	interacts_with	pathway	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Infection	interacts_with	disease	0.50
Proteins	interacts_with	protein	0.50
HO-1	activates	protein	0.50
TNF-α	activates	concept	0.50
IL-18	co_discussed	protein	0.50
IL-1Β	co_discussed	protein	0.50

Incoming (52)

Source	Relation	Type	Str
NLRP3	interacts_with	protein	0.92
NLRP3	activates	protein	0.90
IL1B	part_of	gene	0.90
NLRP3	activates	protein	0.90
P2X7R	activates	protein	0.85
NLRP3	activates	protein	0.80
microglia	activates	cell_type	0.50
IL-1Β	activates	protein	0.50
IL-18	activates	protein	0.50
MLKL	inhibits	gene	0.50
GSDMD	inhibits	protein	0.50
TREM2	activates	gene	0.50
GSDMD	activates	protein	0.50
DEPRESSION	activates	disease	0.50
IL-6	inhibits	protein	0.50
IL-1Β	inhibits	protein	0.50
KEAP1	activates	gene	0.50
NRF2	activates	gene	0.50
NQO1	activates	gene	0.50
IL-6	activates	protein	0.50
NQO1 PROTEIN	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
WAS	causes	protein	0.50
STROKE	interacts_with	gene	0.50
PYCARD	interacts_with	gene	0.50
NLRP3	interacts_with	protein	0.50
DRD2	activates	gene	0.50
TLR4	activates	gene	0.50
GFAP	regulates	gene	0.50
IL-18	regulates	protein	0.50
NLRP3	regulates	protein	0.50
BDNF	associated_with	gene	0.50
GPX4	associated_with	gene	0.50
GFAP	associated_with	gene	0.50
CREB	associated_with	protein	0.50
GASDERMIN D	associated_with	protein	0.50
C1Q	co_discussed	gene	0.50
Neurodegeneration	inhibits	disease	0.50
NLRP3	inhibits	protein	0.50
NAIP	associated_with	gene	0.50
NLRC4	associated_with	gene	0.50
CARD8	associated_with	gene	0.50
GSDMD	associated_with	protein	0.50
NLRP1	associated_with	protein	0.50
NLRP3	associated_with	protein	0.50
microglia	expressed_in	cell_type	0.50
NLRP3	expressed_in	protein	0.50
GASDERMIN D	activates	protein	0.50
IL-10	associated_with	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE-1 in their description or question text

No additional research found