gene

CASP8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

0Experiments

0Debates

Summary

CASP8 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Aging, Als, Autoimmune. Connected to 119 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CASP8
Full Name	Caspase 8
Chromosome	2q33
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	20 kDa
Amino Acids	80 aa
Pathways	Akt, Nf-Κb, Pi3K, Toll-Like Receptor
UniProt ID	[Q14790](https://www.uniprot.org/uniprot/Q14790)
Ensembl ID	ENSG00000164040
GeneCards	CASP8
Human Protein Atlas	CASP8
CASP8a (CASP8)	Full-length canonical isoform
CASP8b	Alternative splice form with unique N-terminus
CASP8L	Long isoform with extended prodomain
Associated Diseases	Als, Autoimmune, Ms, Rheumatoid Arthritis
Known Drugs/Compounds	natural products
Interactions	Actin, AKT1, AND, APOPTOSIS, CANCER, CASP3
KG Connections	177 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

casp8

gene · 2533 words

→

Caspase-8 (CASP8)

protein · 2012 words

→

Pathway Diagram

graph TD
    CASP8["CASP8"]
    CASP8 -->|"target for"| Carcinoma["Carcinoma"]
    CASP8 -->|"target for"| Cancer["Cancer"]
    CASP8 -->|"target for"| Ms["Ms"]
    CASP8 -->|"target for"| Glioblastoma["Glioblastoma"]
    CASP8 -->|"target for"| Inflammation["Inflammation"]
    CASP8 -->|"target for"| Fibrosis["Fibrosis"]
    CASP8 -->|"target for"| Diabetes["Diabetes"]
    CASP8 -->|"interacts"| Als["Als"]
    TLR4["TLR4"] -->|"activates"| CASP8
    UBIQUITIN["UBIQUITIN"] -->|"activates"| CASP8
    TP53["TP53"] -->|"target for"| CASP8
    FAS["FAS"] -->|"interacts"| CASP8
    BCL2L1["BCL2L1"] -.biomarker for.-> CASP8
    BCL2["BCL2"] -->|"regulates"| CASP8
    PI3K["PI3K"] -->|"regulates"| CASP8

Outgoing (131)

Target	Relation	Type	Str
PANoptosis	component_of	process	0.95
Hepatic Apoptosis	mediates	process	0.90
apoptosis	mediates	process	0.90
Depression	involved_in	disease	0.85
TNFR1	interacts_with	gene	0.85
AKT	regulates	gene	0.70
Als	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Autoimmune	associated_with	disease	0.65
Lymphoma	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Leukemia	regulates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Cancer	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Akt	biomarker_for	pathway	0.60
Endothelial	activates	cell_type	0.60
Macrophage	causes	cell_type	0.60
Autophagy	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
CARM1	associated_with	gene	0.60
MTDNA	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
Akt	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
CANCER	interacts_with	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
Actin	activates	protein	0.60
Mapk	activates	pathway	0.60
CFLAR	associated_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
Akt	activates	pathway	0.60
RIPK1	associated_with	gene	0.60
TNFRSF1A	biomarker_for	gene	0.60

Incoming (46)

Source	Relation	Type	Str
natural products	targets	compound	0.75
PI3K	regulates	gene	0.70
TP53	regulates	gene	0.60
TLR4	regulates	gene	0.60
TNF	regulates	gene	0.60
CASP9	regulates	gene	0.60
RAB7A	activates	gene	0.60
TNFSF10	activates	gene	0.60
TNFRSF1A	activates	gene	0.60
FYCO1	activates	gene	0.60
DR5	activates	gene	0.60
BCL2	regulates	gene	0.60
TRAIL	activates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
MAPK	activates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
FAS	interacts_with	gene	0.60
FAS	therapeutic_target	gene	0.60
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
IKBKB	associated_with	gene	0.60
GBM	interacts_with	gene	0.60
MCL1	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
MMP2	interacts_with	gene	0.60
TP53	therapeutic_target	gene	0.60
TRIM32	activates	gene	0.60
ZBP1	activates	gene	0.60
CASP1	regulates	gene	0.60
CASP7	regulates	gene	0.60
STAT3	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
AND	interacts_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AKT1	activates	gene	0.60
RIPK3	activates	gene	0.60
TLR4	activates	gene	0.60
SEPSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASP8 in their description or question text

No additional research found