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protein 876 words KG: GSDMD
Contents

Gasdermin D Protein

🔬 Protein Info
Gene SymbolGSDMD
Functionis a gene encoding a key executor of pyroptotic cell death
Primary Expressionhippocampus, temporal lobe, cortex, Substantia Nigra, Ca1
Molecular Weight56 kDa
Amino Acids484 aa
PathwaysApoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress
GeneCardsGSDMD
Human Protein AtlasGSDMD
Associated DiseasesAls, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis, autism
Known Drugs/Compoundscurcumin, natural products, Pterostilbene, Qingqi Liangying Formula, XHP
InteractionsABCG2, ACSL4, Actin, AGING, AIF, AIM2
KG Connections853 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (18)

Microbial Inflammasome Priming Prevention
Score: 0.65ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Multi-Modal Stress Response Harmonization
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Microglial Purinergic Reprogramming
Score: 0.70TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62Extracellular Vesicle Biogenesis Modulation
Score: 0.58Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (14)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (6)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activatesACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibitsALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibitsAIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: activates

Knowledge Graph (12 edges)

FASN inhibits GSDMD
BAX inhibits GSDMD
ALOX15 inhibits GSDMD
GSDMD inhibits SCD1
GSDMD inhibits HMGCR
GSDMD inhibits TNF
GSDMD inhibits MLKL
GSDMD inhibits ACSL4
POLE activates GSDMD
TREM2 activates GSDMD

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