gene

SCD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

261Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SCD1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, regulates. Associated with Aging, Als, Atherosclerosis. Connected to 131 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SCD1
Chromosome	10q24.31
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	multiple cancers:
Molecular Weight	60 kDa
Amino Acids	360 aa
Pathways	Akt, Autophagy, Ferroptosis, Lipid Metabolism, Mtor
Ensembl ID	ENSG00000197294
GeneCards	SCD1
Human Protein Atlas	SCD1
Enzyme type	Membrane-bound desaturase (EC 1.14.19.3)
Location	Endoplasmic reticulum membrane
Substrate	Stearoyl-CoA (18:0), palmitoyl-CoA (16:0)
Product	Oleoyl-CoA (18:1), palmitoleoyl-CoA (16:1)
Associated Diseases	ALS, cancer, ferroptosis, Fibrosis
Known Drugs/Compounds	Salidroside
Interactions	ACC, ACLY, ACSL4, AKT, ALOX15, AMPK
KG Connections	261 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCD1 Gene

gene · 1200 words

→

SCD1 Protein

protein · 1005 words

→

Pathway Diagram

graph TD
    SCD1["SCD1"]
    SCD1 -->|"inhibits"| FERROPTOSIS["FERROPTOSIS"]
    SCD1 -->|"inhibits"| Inflammation["Inflammation"]
    SCD1 -->|"inhibits"| Hepatitis["Hepatitis"]
    SCD1 -->|"inhibits"| Fibrosis["Fibrosis"]
    SCD1 -->|"activates"| Cancer["Cancer"]
    SCD1 -->|"activates"| Tumor["Tumor"]
    SCD1 -->|"activates"| Aging["Aging"]
    SCD1 -->|"activates"| Ms["Ms"]
    SCD1 -->|"target for"| Als["Als"]
    SREBP1["SREBP1"] -->|"regulates"| SCD1
    FASN["FASN"] -->|"inhibits"| SCD1
    BAX["BAX"] -->|"inhibits"| SCD1
    ALOX15["ALOX15"] -->|"inhibits"| SCD1
    GSDMD["GSDMD"] -->|"inhibits"| SCD1
    MTOR["MTOR"] -->|"inhibits"| SCD1
    PTEN["PTEN"] -->|"activates"| SCD1
    ACSL4["ACSL4"] -->|"inhibits"| SCD1
    TNF["TNF"] -->|"inhibits"| SCD1

Outgoing (155)

Target	Relation	Type	Str
Ferroptosis Resistance	mediates	phenotype	0.90
Ferroptosis	mediates	process	0.90
fatty acid synthesis	involved_in	process	0.90
Lipogenesis	mediates	process	0.90
Monounsaturated Fatty Acid Phospholipids	upregulates	compound	0.85
Lipid Synthesis	involved_in	process	0.80
Tumor	regulates	disease	0.75
FERROPTOSIS	inhibits	phenotype	0.72
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
Lipid Metabolism	regulates	pathway	0.70
ferroptosis	participates_in	pathway	0.70
Ms	regulates	disease	0.65
Obesity	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Insulin Resistance	inhibits	disease	0.65
Ferroptosis	associated_with	disease	0.65
Fatty Liver	inhibits	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	activates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Breast Cancer	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Cancer	regulates	disease	0.65
MTORC1	inhibits	gene	0.60
CANCER	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
SREBP1	activates	gene	0.60
CANCER	regulates	gene	0.60
GENES	regulates	gene	0.60
Ras	inhibits	protein	0.60
AKT	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
FERROPTOSIS	activates	gene	0.60
AND	regulates	gene	0.60
Raf	activates	protein	0.60

Incoming (106)

Source	Relation	Type	Str
SREBP1	upregulates	protein	0.95
EFTUD2	promotes	gene	0.90
EFTUD2	upregulates	gene	0.88
Mi-891	downregulates	drug	0.85
Salidroside	modulates	compound	0.85
SREBP1	regulates	gene	0.72
PTEN	activates	gene	0.60
ACSL4	inhibits	gene	0.60
TNF	inhibits	gene	0.60
PI3K	activates	gene	0.60
GPX4	activates	gene	0.60
NCOA4	regulates	gene	0.60
PI3K	regulates	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
AND	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
DHODH	activates	gene	0.60
FSP1	activates	gene	0.60
FTH1	activates	gene	0.60
ACC	expressed_in	gene	0.60
ERK	expressed_in	gene	0.60
SOD1 DOWNREGULATION	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ROS	inhibits	gene	0.60
SOD1	contributes_to	gene	0.60
NR1D1	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
FASN	expressed_in	entity	0.60
HMGCR	expressed_in	entity	0.60
ATF4	activates	gene	0.60
GSH	activates	gene	0.60
EGR1	inhibits	gene	0.60
ACC	activates	gene	0.60
ACLY	activates	gene	0.60
AMPK	activates	gene	0.60
CXCL1	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
GENES	inhibits	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
CANCER	associated_with	entity	0.60
CANCER	activates	entity	0.60
FERROPTOSIS	inhibits	gene	0.60
CPT1A	inhibits	gene	0.60
FASN	inhibits	gene	0.60
BAX	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity