gene

CARD8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CARD8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

50Outgoing

26Incoming

0Experiments

0Debates

Summary

CARD8 is a key regulator of the NLRP1/NLRP3 inflammasome involved in neuroinflammation and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	CARD8
Full Name	Caspase Recruitment Domain Family Member 8
Chromosome	19q13.33.
Function	is a critical regulator of the innate immune inflammasome complex.
Primary Expression	neurons, astrocytes, and microglia, where it participates in n
Amino Acids	541 aa
Pathways	Pyroptosis
UniProt ID	Q9Y2585
NCBI Gene ID	8912
Ensembl ID	ENSG00000105464
OMIM	609508
GeneCards	CARD8
Human Protein Atlas	CARD8
CARD Domain	Located at the N-terminus, this domain mediates protein-protein interactions with other CARD-containing proteins, particularly caspases
FIIND Domain	The function-to-find domain is required for the autoinflammatory processing of CARD8
Associated Diseases	Als, Autoimmune, Cancer, Cardiovascular, Inflammation
Interactions	AIM2, AND, Caspase, Cytokine, CYTOKINES, GAIN
KG Connections	90 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CARD8 - Caspase Recruitment Domain Family Member 8

gene · 721 words

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Pathway Diagram

graph TD
    CARD8["CARD8"]
    Als{"Als"}
    CARD8 -->|"regulates"| Als
    Ms{"Ms"}
    CARD8 -->|"regulates"| Ms
    Inflammation{"Inflammation"}
    CARD8 -->|"regulates"| Inflammation
    NLRP1["NLRP1"]
    CARD8 -->|"associated with"| NLRP1
    INFLAMMATION["INFLAMMATION"]
    CARD8 -->|"regulates"| INFLAMMATION
    AIM2["AIM2"]
    CARD8 -->|"associated with"| AIM2
    NLRP3["NLRP3"]
    CARD8 -->|"associated with"| NLRP3
    Inflammasome(["Inflammasome"])
    CARD8 -->|"associated with"| Inflammasome
    Pyroptosis(["Pyroptosis"])
    CARD8 -->|"regulates"| Pyroptosis
    neurodegeneration["neurodegeneration"]
    CARD8 -->|"implicated in"| neurodegeneration
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"regulates"| CARD8
    HDAC6["HDAC6"]
    HDAC6 -->|"regulates"| CARD8
    IFI16["IFI16"]
    IFI16 -->|"associated with"| CARD8
    style CARD8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
Nlrp Inflammasomes	involved_in	protein	0.85
pyroptosis	participates_in	pathway	0.70
Autoimmune	implicated_in	disease	0.65
Ms	activates	disease	0.65
Autoimmune	activates	disease	0.65
Inflammation	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Pyroptosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Pyroptosis	interacts_with	disease	0.65
NLRP10	activates	gene	0.60
IL-18	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
IL-1	interacts_with	gene	0.60
PYROPTOSIS	interacts_with	gene	0.60
Caspase	interacts_with	protein	0.60
Rb	associated_with	protein	0.60
Cytokine	interacts_with	protein	0.60
NLRP1	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
Innate Immunity	implicated_in	pathway	0.60
Inflammasome	activates	pathway	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Innate Immunity	activates	pathway	0.60
IL-1	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
NLRP2	activates	gene	0.60
NLRP6	activates	gene	0.60
NLRP7	activates	gene	0.60
NLRP1	activates	gene	0.60
NLRP12	activates	gene	0.60
NLRP3	activates	gene	0.60
GSDMD	associated_with	gene	0.60
GAIN	activates	gene	0.60
NLRP10	associated_with	gene	0.60
NLRP7	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
Inflammasome	associated_with	pathway	0.60
Pyroptosis	regulates	pathway	0.60
NLRP6	associated_with	gene	0.60
NLRP3	interacts_with	gene	0.60

Incoming (26)

Source	Relation	Type	Str
HDAC6	regulates	gene	0.60
IFI16	associated_with	gene	0.60
GAIN	activates	gene	0.60
NLRP1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
NAIP	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
IL-1	associated_with	gene	0.60
AND	associated_with	gene	0.60
NLRP3	activates	gene	0.60
NLRP1	activates	gene	0.60
NLRP2	activates	gene	0.60
GAIN	implicated_in	gene	0.60
NLRP6	activates	gene	0.60
NLRP7	activates	gene	0.60
NLRP12	activates	gene	0.60
NLRP7	associated_with	gene	0.60
AIM2	interacts_with	gene	0.60
PYROPTOSIS	regulates	gene	0.60
NLRC4	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CARD8 in their description or question text

No additional research found