gene

NEK7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEK7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

143Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

NEK7 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, activates. Associated with Als, Carcinoma, Diabetes. Connected to 51 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NEK7
Protein Type	Serine/Threonine Kinase
Function	NEK7 is a 34 kDa serine/threonine kinase that plays dual roles in cell biology:
Molecular Weight	34 kDa
Pathways	Inflammasome
Ensembl ID	ENSG00000151414
GeneCards	NEK7
Human Protein Atlas	NEK7
Associated Diseases	Als, Carcinoma, Encephalitis, Inflammation, Ms, Multiple Sclerosis
Interactions	A20, AMYLOID, AND, ATP, CGAS, CGAS-STING
KG Connections	143 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NEK7 Gene

gene · 924 words

→

NEK7 Protein

protein · 898 words

→

Pathway Diagram

graph TD
    NEK7["NEK7"]
    Ms{"Ms"}
    NEK7 -->|"activates"| Ms
    Inflammation{"Inflammation"}
    NEK7 -->|"activates"| Inflammation
    Diabetes{"Diabetes"}
    NEK7 -->|"inhibits"| Diabetes
    NEK7 -->|"inhibits"| Ms
    NEK7 -->|"inhibits"| Inflammation
    Carcinoma{"Carcinoma"}
    NEK7 -->|"associated with"| Carcinoma
    Als{"Als"}
    NEK7 -->|"associated with"| Als
    NEK7 -->|"associated with"| Ms
    NEK7 -->|"associated with"| Inflammation
    NEK7 -->|"interacts with"| Als
    NLRP3["NLRP3"]
    NEK7 -->|"activates"| NLRP3
    Nf__b(["Nf-Kappab"])
    NEK7 -->|"activates"| Nf__b
    NLRP3 -->|"interacts with"| NEK7
    SLC25A3["SLC25A3"]
    SLC25A3 -->|"inhibits"| NEK7
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"activates"| NEK7
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| NEK7
    NF__B["NF-KappaB"]
    NF__B -->|"activates"| NEK7
    SPR["SPR"]
    SPR -->|"therapeutic target"| NEK7
    LATS1["LATS1"]
    LATS1 -->|"interacts with"| NEK7
    BNIP3["BNIP3"]
    BNIP3 -->|"associated with"| NEK7
    PYROPTOSIS -->|"associated with"| NEK7
    TLR4["TLR4"]
    TLR4 -->|"associated with"| NEK7
    INFLAMMATION -->|"associated with"| NEK7
    STING["STING"]
    STING -->|"associated with"| NEK7
    style NEK7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (108)

Target	Relation	Type	Str
NLRP3 inflammasome activation	promotes	process	0.94
NLRP3 inflammasome	activates	pathway	0.92
Inflammation	activates	disease	0.75
Inflammation	inhibits	disease	0.75
NLRP3	interacts_with	gene	0.70
Inflammasome	inhibits	pathway	0.70
NLRP3	activates	gene	0.70
Inflammasome	activates	pathway	0.70
INFLAMMATION	inhibits	gene	0.70
Encephalitis	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Pyroptosis	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	expressed_in	disease	0.65
Autoimmune	regulates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	associated_with	disease	0.65
neuroinflammation	activates	disease	0.60
NLRP3	associated_with	gene	0.60
Rb	regulates	protein	0.60
GSDMD	activates	gene	0.60
CGAS	inhibits	gene	0.60
TNF	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
RELA	activates	gene	0.60
ASC	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
TLR4	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
NLRP3	inhibits	gene	0.60
Pyroptosis	associated_with	pathway	0.60
LIMK1	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
SPR	therapeutic_target	gene	0.60
JNK	associated_with	gene	0.60
DSDNA	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
SELF-DNA	inhibits	gene	0.60
NLRC4	associated_with	gene	0.60

Incoming (35)

Source	Relation	Type	Str
A20	binds_to	protein	0.95
A20	upstream_of	protein	0.91
NLRP3	interacts_with	protein	0.90
A20	phosphorylates	protein	0.90
SLC25A3	inhibits	protein	0.80
RAB7A	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
SORT1	interacts_with	gene	0.60
STING	associated_with	gene	0.60
TLR4	associated_with	gene	0.60
BNIP3	associated_with	gene	0.60
NLRP3	regulates	gene	0.60
NLRP3	activates	gene	0.60
TAK1	associated_with	gene	0.60
TIRAP	associated_with	gene	0.60
PAK1	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
NF-ΚB	activates	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CREB	associated_with	gene	0.60
ERK1/2	associated_with	gene	0.60
SPR	therapeutic_target	gene	0.60
LATS1	interacts_with	gene	0.60
TNFAIP3	inhibits	gene	0.60
OGT	regulates	gene	0.60
NEK1	associated_with	gene	0.60
MITOCHONDRIA	activates	gene	0.60
GSDMD	expressed_in	gene	0.60
GSDMD	activates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
PYROPTOSIS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEK7 in their description or question text

No additional research found