gene

SFN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SFN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

0Experiments

0Debates

Summary

SFN is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Aging, Als, Cancer. Connected to 66 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SFN
Full Name	Stratifin (14-3-3 sigma)
Chromosome	1p36.22
Function	SFN encodes 14-3-3 sigma, which has unique functions in neurons
Primary Expression	various tissues with notable brain expression in: - Cerebral cortex - Hippocampus - [Cerebellum
Pathways	Autophagy, Cell Cycle, Differentiation, Epigenetic, Nf-Κb
UniProt ID	P31947
NCBI Gene ID	6278
Ensembl ID	ENSG00000175793
OMIM	605225
GeneCards	SFN
Human Protein Atlas	SFN
Associated Diseases	Cancer, Lung Cancer, neurodegeneration, Tumor
Known Drugs/Compounds	dasatinib, NFE2L2, quercetin, rapamycin
Interactions	AGING, AMPK, APOPTOSIS, ATG5, AUTOPHAGY, BAX
KG Connections	108 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SFN — AlphaFold P31947 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SFN Gene

gene · 640 words

→

Septofimbrial Nucleus (SFN) Neurons

cell · 637 words

→

Pathway Diagram

graph TD
    SFN["SFN"]
    NFE2L2["NFE2L2"]
    SFN -->|"activates"| NFE2L2
    Ms{"Ms"}
    SFN -->|"activates"| Ms
    Aging{"Aging"}
    SFN -->|"activates"| Aging
    Cancer{"Cancer"}
    SFN -->|"activates"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    SFN -->|"activates"| Neurodegeneration
    AMPK["AMPK"]
    SFN -->|"associated with"| AMPK
    LC3["LC3"]
    SFN -->|"activates"| LC3
    Mtor(["Mtor"])
    SFN -->|"associated with"| Mtor
    Autophagy(["Autophagy"])
    SFN -->|"regulates"| Autophagy
    Oxidative_Stress(["Oxidative Stress"])
    SFN -->|"activates"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    SFN -->|"implicated in"| neurodegeneration
    ATG5["ATG5"]
    ATG5 -->|"activates"| SFN
    ULK1["ULK1"]
    ULK1 -->|"associated with"| SFN
    MTOR["MTOR"]
    MTOR -->|"associated with"| SFN
    AGING["AGING"]
    AGING -->|"activates"| SFN
    NFE2L2 -->|"regulates"| SFN
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| SFN
    CANCER["CANCER"]
    CANCER -->|"activates"| SFN
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| SFN
    NRF2["NRF2"]
    NRF2 -->|"regulates"| SFN
    style SFN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (60)

Target	Relation	Type	Str
Cancer	activates	disease	0.75
NFE2L2	activates	protein	0.70
Aging	activates	disease	0.65
Pyroptosis	activates	disease	0.65
Necroptosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Lung Cancer	implicated_in	disease	0.65
Cancer	protects_against	disease	0.65
Als	activates	disease	0.65
Senescence	regulates	disease	0.65
Tumor	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Epigenetic	regulates	pathway	0.60
Autophagy	activates	pathway	0.60
SYP	activates	gene	0.60
GENES	regulates	gene	0.60
Differentiation	regulates	pathway	0.60
Apoptosis	activates	pathway	0.60
Cell Cycle	regulates	pathway	0.60
Nf-Κb	regulates	pathway	0.60
AMPK	activates	gene	0.60
Toll-Like Receptor	activates	pathway	0.60
Invasion	activates	pathway	0.60
NRF2	regulates	gene	0.60
T Cell	activates	cell_type	0.60
P62	activates	gene	0.60
TFEB	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
TRPML1	activates	gene	0.60
LC3	activates	gene	0.60
TRAF6	activates	gene	0.60
MMP9	implicated_in	gene	0.60
UBIQUITIN	activates	gene	0.60
ULK1	causes	gene	0.60
MTOR	causes	gene	0.60
IL18	regulates	gene	0.60
NLRP3	activates	gene	0.60
GSDMD	activates	gene	0.60
IL6	regulates	gene	0.60
BAX	activates	gene	0.60
AND	associated_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
neurodegeneration	associated_with	disease	0.60
LIPOPHAGY	causes	gene	0.60
AUTOPHAGY	regulates	gene	0.60

Incoming (48)

Source	Relation	Type	Str
CANCER	activates	gene	0.70
TLR4	activates	gene	0.60
MYO7A	implicated_in	gene	0.60
WIF1	implicated_in	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NF-ΚB	regulates	gene	0.60
CANCER	protects_against	gene	0.60
ROS	activates	gene	0.60
KEAP1	regulates	gene	0.60
FERROPTOSIS	activates	gene	0.60
ATG5	activates	gene	0.60
ULK1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NFE2L2	regulates	gene	0.60
NRF2	regulates	gene	0.60
LC3	activates	gene	0.60
NFE2L2	activates	gene	0.60
NRF2	activates	gene	0.60
MTOR	activates	gene	0.60
CAT	activates	gene	0.60
HMOX1	activates	gene	0.60
KEAP1	activates	gene	0.60
LAMP1	activates	gene	0.60
MCOLN1	activates	gene	0.60
PP2A	activates	gene	0.60
RPS6KB1	activates	gene	0.60
quercetin	targets	drug	0.60
dasatinib	targets	drug	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
SLC7A11	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CANCER	implicated_in	gene	0.60
GENES	implicated_in	gene	0.60
PYROPTOSIS	activates	gene	0.60
AQP4	regulates	gene	0.60
MMP9	regulates	gene	0.60
NPC1	activates	gene	0.60
GFP	activates	gene	0.60
AMPK	causes	gene	0.60
rapamycin	targets	drug	0.60
MTORC1	activates	gene	0.60
S6K1	activates	gene	0.60
RPS6KB1	co_expressed_with	gene	0.50
S6K1	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SFN in their description or question text

No additional research found