gene

TIRAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIRAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

0Analyses

46Outgoing

6Incoming

0Experiments

0Debates

Summary

Gene profile: TIRAP (TIR Domain-Containing Adaptor Protein)

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🧬 Gene Info

Gene Symbol	TIRAP
Full Name	TIR Domain-Containing Adaptor Protein
Chromosome	11p15.5
Protein Type	Adaptor Protein
Function	is a critical signaling adaptor protein that mediates Toll-like receptor (TLR) signaling in the innate immune system.
Primary Expression	microglia, astrocytes, and neurons, where it contributes to neuroinflammator
Molecular Weight	28 kDa
Amino Acids	235 aa
Exons	6
Pathways	Immune Response
NCBI Gene ID	114609
Ensembl ID	ENSG00000150459
GeneCards	TIRAP
Human Protein Atlas	TIRAP
N-terminal domain	Contains a phosphatidylinositol 4,5-bisphosphate (PIP2)-binding motif that enables membrane localization
Associated Diseases	ALS, Encephalitis, Inflammation, Multiple Sclerosis, neurodegeneration
Interactions	AND, CD14, MyD88, MYD88, NF-ΚB, TLR
KG Connections	52 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TIRAP — TIR Domain-Containing Adaptor Protein

gene · 1194 words

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Pathway Diagram

graph TD
    TIRAP["TIRAP"]
    MyD88_dependent_pathway(["MyD88-dependent pathway"])
    TIRAP -->|"participates in"| MyD88_dependent_pathway
    MyD88["MyD88"]
    TIRAP -->|"interacts with"| MyD88
    Als{"Als"}
    TIRAP -->|"interacts with"| Als
    Ms{"Ms"}
    TIRAP -->|"interacts with"| Ms
    Inflammation{"Inflammation"}
    TIRAP -->|"associated with"| Inflammation
    Nf__b(["Nf-Kappab"])
    TIRAP -->|"activates"| Nf__b
    Toll_Like_Receptor(["Toll-Like Receptor"])
    TIRAP -->|"interacts with"| Toll_Like_Receptor
    TLR["TLR"]
    TIRAP -->|"activates"| TLR
    INFLAMMATION["INFLAMMATION"]
    TIRAP -->|"associated with"| INFLAMMATION
    MYD88["MYD88"]
    TIRAP -->|"activates"| MYD88
    Immune_Response(["Immune Response"])
    TIRAP -->|"regulates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    TIRAP -->|"implicated in"| neurodegeneration
    TLR -->|"activates"| TIRAP
    TLR4["TLR4"]
    TLR4 -->|"activates"| TIRAP
    CD14["CD14"]
    CD14 -->|"activates"| TIRAP
    NF__B["NF-KappaB"]
    NF__B -->|"activates"| TIRAP
    style TIRAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
MyD88	interacts_with	protein	0.80
MyD88-dependent pathway	participates_in	pathway	0.80
Inflammation	associated_with	disease	0.65
Encephalitis	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	interacts_with	disease	0.65
Nf-Κb	activates	pathway	0.60
Toll-Like Receptor	interacts_with	pathway	0.60
AND	activates	gene	0.60
NF-ΚB	activates	gene	0.60
CREB	associated_with	gene	0.60
ERK1/2	associated_with	gene	0.60
TCR	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Epithelial	associated_with	cell_type	0.60
Monocyte	associated_with	cell_type	0.60
T Cell	associated_with	cell_type	0.60
Endothelial	associated_with	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
Actin	associated_with	protein	0.60
Interleukin	associated_with	protein	0.60
TLR4	activates	gene	0.60
Interferon	associated_with	protein	0.60
CD14	activates	gene	0.60
JNK	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
LIMK1	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
ASC	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
TNF	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
TLR	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
Immune Response	regulates	pathway	0.60
MYD88	activates	gene	0.60
PAK1	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
NEK7	associated_with	gene	0.60
ALS	associated_with	disease	0.60
TLR4	co_expressed_with	gene	0.50

Incoming (6)

Source	Relation	Type	Str
TLR4	activates	gene	0.60
CD14	activates	gene	0.60
TLR	activates	gene	0.60
NF-ΚB	activates	gene	0.60
TAK1	associated_with	gene	0.60
CD14	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIRAP in their description or question text

No additional research found