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gene 565 words KG: GSDMD
Contents

GSDMD Gene

🧬 Gene Info
Gene SymbolGSDMD
Functionis a gene encoding a key executor of pyroptotic cell death
Primary Expressionhippocampus, temporal lobe, cortex, Substantia Nigra, Ca1
Molecular Weight56 kDa
Amino Acids484 aa
PathwaysApoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress
GeneCardsGSDMD
Human Protein AtlasGSDMD
Associated DiseasesAls, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis, autism
Known Drugs/Compoundscurcumin, natural products, Pterostilbene, Qingqi Liangying Formula, XHP
InteractionsABCG2, ACSL4, Actin, AGING, AIF, AIM2
KG Connections853 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Multi-Modal Stress Response Harmonization
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75CYP46A1 Overexpression Gene Therapy
Score: 0.73Microglial Purinergic Reprogramming
Score: 0.70TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66TREM2-mediated microglial tau clearance enhancement
Score: 0.62Extracellular Vesicle Biogenesis Modulation
Score: 0.58Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (10)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (7)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activatesACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibitsAIF Gene
gene · KG edge: regulatesALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

FASN inhibits GSDMD
BAX inhibits GSDMD
ALOX15 inhibits GSDMD
GSDMD inhibits SCD1
GSDMD inhibits HMGCR
GSDMD inhibits TNF
GSDMD inhibits MLKL
GSDMD inhibits ACSL4
POLE activates GSDMD
TREM2 activates GSDMD

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