concept

CURCUMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CURCUMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

409Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CURCUMIN
Key Genes/Proteins	ACSL4, AKT, AMPK, AMYLOID, AMYLOID-BETA, aplp1
Related Diseases	ACETYLCHOLINE, aging, AGING, ALZHEIMER, Alzheimer'S Disease

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Curcumin for Neurodegeneration

therapeutic · 4017 words

→

Pathway Diagram

graph TD
    CURCUMIN["CURCUMIN"]
    CURCUMIN -->|"treats"| Gastric_Cancer["Gastric Cancer"]
    CURCUMIN -->|"activates"| Ferroptosis["Ferroptosis"]
    CURCUMIN -->|"activates"| Autophagy["Autophagy"]
    CURCUMIN -->|"inhibits"| PI3K_AKT_mTOR_Signaling_Pathwa["PI3K/AKT/mTOR Signaling Pathway"]
    CURCUMIN -->|"inhibits"| Inflammation["Inflammation"]
    CURCUMIN -->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
    CURCUMIN -->|"treats"| Intestinal_Barrier_Injury["Intestinal Barrier Injury"]
    CURCUMIN -->|"inhibits"| reactive_oxygen_species["reactive oxygen species"]
    Ampk_Tfeb["Ampk-Tfeb"] -->|"mediates"| CURCUMIN
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CURCUMIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| CURCUMIN
    AGING["AGING"] -->|"activates"| CURCUMIN
    CANCER["CANCER"] -->|"activates"| CURCUMIN
    ATG5["ATG5"] -->|"activates"| CURCUMIN
    ATG7["ATG7"] -->|"activates"| CURCUMIN

Outgoing (273)

Target	Relation	Type	Str
Oxidative Stress	associated_with	process	0.95
Gastric Cancer	treats	disease	0.95
Ferroptosis	activates	process	0.94
Autophagy	activates	process	0.93
PI3K/AKT/mTOR Signaling Pathway	inhibits	pathway	0.92
Intestinal Barrier Injury	treats	disease	0.90
STAT1	inhibits	gene	0.90
reactive oxygen species	inhibits	process	0.90
Mitochondrial Damage	associated_with	disease	0.90
JAK2	inhibits	gene	0.90
STAT3	inhibits	gene	0.90
STAT3	suppresses	gene	0.90
Inflammation	inhibits	process	0.90
Oxidative Stress	inhibits	process	0.90
IL-17/NF-κB Signaling Pathway	inhibits	pathway	0.88
BECN1	upstream_of	gene	0.85
Rheumatoid Arthritis	treats	disease	0.85
neuroinflammation	associated_with	process	0.85
Spinal Cord Injury	treats	disease	0.85
NF-KB	modulates	gene	0.85
AMPK	activates	protein	0.85
Neuroinflammation	inhibits	process	0.85
neural mitochondrial dysfunction	associated_with	process	0.85
STAT6	activates	gene	0.85
MMP9	targets	protein	0.85
mitochondrial dysfunction	associated_with	process	0.85
Cell Apoptosis	associated_with	process	0.82
Age-Related Disorders	treats	disease	0.80
AKT	activates	protein	0.80
OPRL1	downregulates	gene	0.80
PI3K	activates	pathway	0.80
Parkinson's Disease	treats	disease	0.80
Apoptotic Pathways	modulates	pathway	0.80
PI3K/Akt signaling	activates	pathway	0.80
NEURODEGENERATION	protects_against	disease	0.80
Mitochondrial Dysfunction	modulates	process	0.80
Healthy Aging	associated_with	phenotype	0.80
SOCS1	upregulates	gene	0.80
Neurodegeneration	protects_against	disease	0.80
BDNF	activates	protein	0.80
Cognitive Function	protects_against	phenotype	0.80
Apoptosis	modulates	process	0.75
NAMPT/NAD+ pathway	activates	pathway	0.75
KL	modulates	gene	0.75
Alzheimer's disease	treats	disease	0.70
cell apoptosis	inhibits	process	0.70
PI3K/AKT/mTOR	regulates	pathway	0.70
Parkinson's disease	treats	disease	0.70
neurogenesis	activates	process	0.70
apoptosis	regulates	process	0.70

Incoming (136)

Source	Relation	Type	Str
Ampk-Tfeb	mediates	pathway	0.80
CANCER	treats	disease	0.65
ATG5	promotes	gene	0.65
ATG7	promotes	gene	0.65
STROKE	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
ALZHEIMER	treats	disease	0.65
RAPAMYCIN	implicated_in	drug	0.55
PI3K/AKT/mTOR	activates	pathway	0.50
ferroptosis	inhibits	phenotype	0.50
aplp1	interacts_with	gene	0.50
MMP9	interacts_with	gene	0.50
CLDN5	interacts_with	gene	0.50
Sod1	interacts_with	gene	0.50
NATURAL COMPOUNDS	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50
inflammation	activates	pathway	0.50
aging	associated_with	phenotype	0.50
Neurodegeneration	associated_with	disease	0.50
aging	activates	phenotype	0.50
Pi3K	activates	pathway	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50
cancer	activates	disease	0.50
ferroptosis	activates	phenotype	0.50
Pi3K/Akt	activates	pathway	0.50
Gastric Cancer	activates	disease	0.50
APOPTOSIS	activates	process	0.50
MTOR SIGNALING	activates	concept	0.50
cancer	associated_with	disease	0.50
TUMOR	associated_with	disease	0.50
TUMOR	regulates	disease	0.50
ferroptosis	regulates	phenotype	0.50
Gastric Cancer	associated_with	disease	0.50
CELL DEATH	activates	concept	0.50
LC3B	activates	protein	0.50
Pi3K	inhibits	pathway	0.50
mTOR	inhibits	entity	0.50
TGFB1	regulates	gene	0.50
TNFA	regulates	gene	0.50
C3AR1	regulates	gene	0.50
disease	regulates	disease	0.50
Nf-Kb	regulates	pathway	0.50
AMYLOID-BETA	associated_with	protein	0.50
oxidative stress	activates	phenotype	0.50
oxidative stress	associated_with	phenotype	0.50
apoptosis	activates	process	0.50
NF-κB	activates	concept	0.50
Rheumatoid Arthritis	activates	disease	0.50
BDNF	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity