gene

NAIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

24Incoming

0Experiments

0Debates

Summary

NAIP (NLR Apoptosis Inhibitor Protein): NLR family protein involved in innate immunity, inflammasome activation, and cell death regulation. Implicated in ALS, SMA, and neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	NAIP
Full Name	NLR Apoptosis Inhibitor Protein
Chromosome	5q13.2
Protein Family	NLR family (BIRC family)
Protein Type	Receptor
Function	is a member of the NLR (NOD-like receptor) family of proteins that functions as both a pattern recognition receptor in innate immunity and an inhibitor of apoptosis.
Primary Expression	neurons and glial cells, where it participates in neuroinflammatory processes relevant to neurodegenerative diseases including Alzheimer's disease (AD
Amino Acids	658 aa
Pathways	Inflammasome, Toll-Like Receptor, apoptosis pathway, pyroptosis
UniProt ID	P25116
NCBI Gene ID	4669
Ensembl ID	ENSG00000140030
OMIM	147450
GeneCards	NAIP
Human Protein Atlas	NAIP
Associated Diseases	Als, Cancer, Cardiovascular, Colorectal Cancer, Dementia
Interactions	AIM2, APOPTOSIS, Caspase, CYTOKINES, INFLAMMATION, NLR
KG Connections	111 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NAIP — AlphaFold P25116 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NAIP Gene

gene · 1691 words

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Pathway Diagram

graph TD
    NAIP["NAIP"]
    Dementia{"Dementia"}
    NAIP -->|"associated with"| Dementia
    Inflammation{"Inflammation"}
    NAIP -->|"associated with"| Inflammation
    Metabolic_Syndrome{"Metabolic Syndrome"}
    NAIP -->|"interacts with"| Metabolic_Syndrome
    Cardiovascular{"Cardiovascular"}
    NAIP -->|"interacts with"| Cardiovascular
    NAIP -->|"interacts with"| Inflammation
    Als{"Als"}
    NAIP -->|"interacts with"| Als
    Ms{"Ms"}
    NAIP -->|"interacts with"| Ms
    CYTOKINES["CYTOKINES"]
    NAIP -->|"expressed in"| CYTOKINES
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    NAIP -->|"expressed in"| PROINFLAMMATORY_CYTOKINES
    TNF["TNF"]
    NAIP -->|"expressed in"| TNF
    INFLAMMATION["INFLAMMATION"]
    NAIP -->|"associated with"| INFLAMMATION
    TNF__["TNF-Alpha"]
    NAIP -->|"expressed in"| TNF__
    PYCARD["PYCARD"]
    PYCARD -->|"expressed in"| NAIP
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"interacts with"| NAIP
    style NAIP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (87)

Target	Relation	Type	Str
Dementia	associated_with	disease	0.65
Als	activates	disease	0.65
Pyroptosis	activates	disease	0.65
Als	causes	disease	0.65
Cardiovascular	causes	disease	0.65
ALS	causes	disease	0.65
Inflammation	causes	disease	0.65
Metabolic Syndrome	causes	disease	0.65
Inflammation	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Tumor	implicated_in	disease	0.65
Colorectal Cancer	implicated_in	disease	0.65
Ulcerative Colitis	implicated_in	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Metabolic Syndrome	interacts_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Apoptosis	implicated_in	pathway	0.60
Immune Response	implicated_in	pathway	0.60
Necroptosis	implicated_in	pathway	0.60
CYTOKINES	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
Phagocytosis	interacts_with	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Inflammasome	interacts_with	pathway	0.60
Immune Response	interacts_with	pathway	0.60
Epigenetic	interacts_with	pathway	0.60
PYROPTOSIS	implicated_in	gene	0.60
P53	contributes_to	gene	0.60
CANCER	implicated_in	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
Neutrophil	causes	cell_type	0.60
Cytokine	causes	protein	0.60
IL-1	associated_with	gene	0.60
IL-6	expressed_in	gene	0.60
Inflammasome	expressed_in	pathway	0.60
TLR	activates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
NLR	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
NLRC4	activates	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60

Incoming (24)

Source	Relation	Type	Str
PHAGOCYTOSIS	interacts_with	gene	0.60
APOPTOSIS	implicated_in	gene	0.60
NLRP1	associated_with	gene	0.60
NLRP3	causes	gene	0.60
P38	activates	gene	0.60
AIM2	activates	gene	0.60
CARD8	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
AIM2	interacts_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
IL-1	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	causes	gene	0.60
INFLAMMATION	causes	gene	0.60
CYTOKINES	causes	gene	0.60
AND	causes	gene	0.60
NLR	causes	gene	0.60
PYCARD	expressed_in	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
APOPTOSIS	inhibits	gene	0.60
NLRP3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NAIP in their description or question text

No additional research found