protein

NLRP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

355Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NLRP1 is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, contributes to. Associated with Aging, Als, Alzheimer. Connected to 101 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NLRP1
Full Name	NLRP1 (NLR Family Pyrin Domain Containing 1)
Chromosome	17p13.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various tissues with highest expression in:
Molecular Weight	213 kDa
Amino Acids	1839 aa
Pathways	Inflammasome, Pyroptosis
UniProt ID	Q9Y258
NCBI Gene ID	22821
Ensembl ID	ENSG00000091592
GeneCards	NLRP1
Human Protein Atlas	NLRP1
Tau pathology	Phosphorylated tau directly interacts with NLRP1, promoting inflammasome assembly in AD neurons
Associated Diseases	Als, Autoimmune, Cancer, Carcinoma, Cardiovascular
Known Drugs/Compounds	rapamycin
Interactions	AGING, AIFM1, AIM2, Akt, AKT, ALZHEIMER
KG Connections	355 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NLRP1 — AlphaFold Q9Y258 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NLRP1["NLRP1"]
    Major_depressive_disorder{"Major depressive disorder"}
    NLRP1 -->|"associated with"| Major_depressive_disorder
    autophagy(["autophagy"])
    NLRP1 -->|"regulates"| autophagy
    pro_inflammatory_cytokines["pro-inflammatory cytokines"]
    NLRP1 -->|"activates"| pro_inflammatory_cytokines
    major_depressive_disorder{"major depressive disorder"}
    NLRP1 -->|"associated with"| major_depressive_disorder
    Ms{"Ms"}
    NLRP1 -->|"activates"| Ms
    Tumor{"Tumor"}
    NLRP1 -->|"inhibits"| Tumor
    Als{"Als"}
    NLRP1 -->|"expressed in"| Als
    Cancer{"Cancer"}
    NLRP1 -->|"inhibits"| Cancer
    NLRP1 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    NLRP1 -->|"associated with"| Carcinoma
    NLRP1 -->|"regulates"| Als
    NLRP1 -->|"regulates"| Ms
    chronic_social_defeat_stress(["chronic social defeat stress"])
    chronic_social_defeat_stress -->|"activates"| NLRP1
    BAX["BAX"]
    BAX -->|"activates"| NLRP1
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"regulates"| NLRP1
    HDAC6["HDAC6"]
    HDAC6 -->|"regulates"| NLRP1
    IFI16["IFI16"]
    IFI16 -->|"associated with"| NLRP1
    CARD8["CARD8"]
    CARD8 -->|"associated with"| NLRP1
    style NLRP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (240)

Target	Relation	Type	Str
Depression	associated_with	disease	0.95
INFLAMMATION	promotes	process	0.90
CYTOKINES	upregulates	protein	0.85
Nlrp Inflammasomes	involved_in	protein	0.85
pyroptosis	participates_in	pathway	0.80
DEPRESSION	associated_with	disease	0.80
PI3K	activates	protein	0.80
Inflammasome	activates	pathway	0.80
Als	activates	disease	0.75
Inflammation	activates	disease	0.75
CYTOKINES	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
IL-6	activates	gene	0.70
autophagy	regulates	process	0.70
pro-inflammatory cytokines	activates	protein	0.70
major depressive disorder	associated_with	disease	0.70
apoptosis pathway	participates_in	pathway	0.70
Major depressive disorder	associated_with	disease	0.70
Depression	regulates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Pyroptosis	activates	disease	0.65
Aging	activates	disease	0.65
Autoimmune	implicated_in	disease	0.65
Lymphoma	phosphorylates	disease	0.65
Ms	contributes_to	disease	0.65
Alzheimer	expressed_in	disease	0.65
Pyroptosis	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Pyroptosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Dementia	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Als	expressed_in	disease	0.65

Incoming (115)

Source	Relation	Type	Str
MTOR	interacts_with	protein	0.90
AUTOPHAGY	suppresses	process	0.85
chronic social defeat stress	activates	process	0.70
NLRP3	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
PYROPTOSIS	regulates	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
NLRP12	activates	gene	0.60
DEPRESSION	regulates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
NF-ΚB	contributes_to	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
CREB	contributes_to	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
BAX	activates	gene	0.60
BAX	phosphorylates	gene	0.60
BCL2	phosphorylates	gene	0.60
BCL2	expressed_in	gene	0.60
HDAC6	regulates	gene	0.60
IFI16	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
S100A9	inhibits	gene	0.60
NLRP3	regulates	gene	0.60
IL18	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
BCL-2	phosphorylates	gene	0.60
CYTOKINES	phosphorylates	gene	0.60
NEUROINFLAMMATION	expressed_in	gene	0.60
IL-18	interacts_with	gene	0.60
rapamycin	targets	drug	0.60
ASC	inhibits	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
TLR3	contributes_to	gene	0.60
TAU	therapeutic_target	gene	0.60
PI3K	contributes_to	gene	0.60
BDNF	contributes_to	gene	0.60
TRKB	contributes_to	gene	0.60
PKC	contributes_to	gene	0.60
CDK5	contributes_to	gene	0.60
TLR4	contributes_to	gene	0.60
GAIN	activates	gene	0.60
CARD8	activates	gene	0.60
NLRP2	activates	gene	0.60
NLRP6	activates	gene	0.60
NLRP7	activates	gene	0.60
MTOR	phosphorylates	gene	0.60
TLR4	expressed_in	gene	0.60
AIFM1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NLRP1 in their description or question text

No additional research found