gene

IL18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

335Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IL18 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with Atherosclerosis, Fibrosis, Inflammation. Connected to 97 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL18
Full Name	Interleukin-18
Chromosome	11q22.2-q22.3
Function	Gene expression: The IL18 gene is induced by NF-κB and AP-1 transcription factors in response to TLR ligands, TNF, and IL-1β
Subcellular Localization	</b></td><td>Cytoplasm, Secreted</td></tr>
Molecular Weight	24 kDa
Amino Acids	192 aa
Pathways	NF-κB
UniProt ID	[Q14116](https://www.uniprot.org/uniprot/Q14116)
Ensembl ID	ENSG00000150782
GeneCards	IL18
Human Protein Atlas	IL18
Associated Diseases	Alcohol Use Disorder, ALS, Alzheimer, Fibrosis, Inflammation, Ms
Interactions	ALZHEIMER, AMYLOID, Amyloid-Beta, AMYLOID-BETA, AND, APOPTOSIS
KG Connections	335 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL18["IL18"] -->|"activates"| Ms["Ms"]
    IL18["IL18"] -->|"associated"| Tumor["Tumor"]
    IL18["IL18"] -->|"activates"| Inflammation["Inflammation"]
    IL18["IL18"] -.->|"inhibits"| Ms_1["Ms"]
    IL18["IL18"] -->|"activates"| Tumor_2["Tumor"]
    IL18["IL18"] -->|"activates"| Atherosclerosis["Atherosclerosis"]
    NLRP3_INFLAMMASOME["NLRP3_INFLAMMASOME"] -->|"produces"| IL18["IL18"]
    IL1B["IL1B"] -->|"associated"| IL18["IL18"]
    ATG5["ATG5"] -->|"associated"| IL18["IL18"]
    TNF["TNF"] -->|"associated"| IL18["IL18"]
    style IL18 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (195)

Target	Relation	Type	Str
Pyroptosis	mediates	process	0.90
Oxaliplatin-Induced Peripheral Neuropathy	causes	disease	0.90
Pyroptosis	promotes	process	0.85
Neuroinflammation	promotes	process	0.80
Pyroptosis	product_of	process	0.80
Tumor	associated_with	disease	0.75
Autophagy	associated_with	pathway	0.70
Toll-Like Receptor	associated_with	pathway	0.70
pyroptosis	participates_in	pathway	0.70
Inflammation	activates	disease	0.65
Obesity	activates	disease	0.65
OXALIPLATIN	protects_against	drug	0.65
Alzheimer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Ptsd	inhibits	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Pyroptosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuropathy	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	activates	disease	0.65
Senescence	activates	disease	0.65
ALS	activates	disease	0.65
Alcohol Use Disorder	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
P2RX7	inhibits	gene	0.65
Fibrosis	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	activates	disease	0.65
AND	expressed_in	gene	0.60
P2RX7	regulates	gene	0.60
GENES	inhibits	gene	0.60
neurodegeneration	activates	disease	0.60
IL1B	activates	gene	0.60
IL6	activates	gene	0.60
COL1A1	inhibits	gene	0.60
SNCA	biomarker_for	gene	0.60
IL18BP	therapeutic_target	gene	0.60
BAX	activates	gene	0.60
Phagocytosis	associated_with	pathway	0.60
Rb	inhibits	protein	0.60
IL6	regulates	gene	0.60
Apoptosis	associated_with	pathway	0.60

Incoming (140)

Source	Relation	Type	Str
NLRP3 Inflammasome	associated_with	mechanism	0.95
NLRP3	activates	protein	0.95
INFLAMMASOME COMPLEX	associated_with	protein	0.90
Litebamine	downregulates	compound	0.90
NLRP3	upregulates	gene	0.90
NLRP3 Inflammasome	upregulates	pathway	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
Stress	downregulates	process	0.90
NLRP3	regulates	gene	0.90
NLRP3/caspase-1/GSDMD	upregulates	pathway	0.90
Familiar Context Stress	downregulates	process	0.85
pyroptosis	promotes	process	0.85
NLRP3	associated_with	protein	0.85
CASP1	upregulates	gene	0.85
NLRP3	interacts_with	gene	0.80
Xiyangshen Sanqi Danshen Granules	downregulates	drug	0.80
AUTOPHAGY	associated_with	gene	0.70
ATG5	associated_with	gene	0.70
GENES	associated_with	gene	0.70
TNF	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
NLRP3_INFLAMMASOME	produces	pathway	0.64
APOPTOSIS	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
CXCL8	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
MIRNAS	activates	gene	0.60
GENES	activates	gene	0.60
P21	activates	gene	0.60
P16	activates	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
MICRORNAS	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
CCL4	associated_with	gene	0.60
AMYLOID-BETA	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	regulates	gene	0.60
IL12	associated_with	gene	0.60
AND	activates	gene	0.60
IFN	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GUT-BRAIN AXIS	associated_with	gene	0.60
CALCA	associated_with	gene	0.60
BDNF	activates	gene	0.60
IL1B	associated_with	gene	0.60
ASC	associated_with	gene	0.60
CRH	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL18 in their description or question text

No additional research found