gene

DYRK1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYRK1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

224Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

DYRK1A gene page - Down syndrome kinase, tau phosphorylation, AD/PD

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🧬 Gene Info

Gene Symbol	DYRK1A
Full Name	Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A
Aliases	DYRK1A gene page, Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Chromosome	21q22.13
Protein Type	Serine/Threonine Kinase
Function	The DYRK1A gene encodes Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A, a member of the dual-specificity tyrosine-regulated kinase (DYRK) family.
Primary Expression	individuals with trisomy 21 (Down syndrome)
Molecular Weight	85 kDa
Amino Acids	754 aa
Pathways	Apoptosis, Differentiation
UniProt ID	Q13627
NCBI Gene ID	1785
Ensembl ID	ENSG00000157540
OMIM	600855
GeneCards	DYRK1A
Human Protein Atlas	DYRK1A
Associated Diseases	Als, Alzheimer, Cancer, epilepsy
Interactions	AD, AKT, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections	224 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DYRK1A — AlphaFold Q13627 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DYRK1A["DYRK1A"]
    Ms{"Ms"}
    DYRK1A -->|"regulates"| Ms
    Stroke{"Stroke"}
    DYRK1A -->|"regulates"| Stroke
    Neurodegeneration{"Neurodegeneration"}
    DYRK1A -->|"regulates"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    DYRK1A -->|"regulates"| Alzheimer
    SMAC["SMAC"]
    DYRK1A -->|"regulates"| SMAC
    AIF["AIF"]
    DYRK1A -->|"regulates"| AIF
    Apoptosis(["Apoptosis"])
    DYRK1A -->|"regulates"| Apoptosis
    APOPTOSIS["APOPTOSIS"]
    DYRK1A -->|"activates"| APOPTOSIS
    DYRK1A -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    DYRK1A -->|"implicated in"| neurodegeneration
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| DYRK1A
    E2F1["E2F1"]
    E2F1 -->|"regulates"| DYRK1A
    P53["P53"]
    P53 -->|"regulates"| DYRK1A
    MYC["MYC"]
    MYC -->|"regulates"| DYRK1A
    DIABLO["DIABLO"]
    DIABLO -->|"regulates"| DYRK1A
    EGF["EGF"]
    EGF -->|"regulates"| DYRK1A
    ERK1["ERK1"]
    ERK1 -->|"regulates"| DYRK1A
    APOPTOSIS -->|"regulates"| DYRK1A
    MDM2["MDM2"]
    MDM2 -->|"regulates"| DYRK1A
    RAF1["RAF1"]
    RAF1 -->|"regulates"| DYRK1A
    P38["P38"]
    P38 -->|"regulates"| DYRK1A
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| DYRK1A
    style DYRK1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (160)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.90
epileptogenic brain lesions	implicated_in	disease	0.80
NEURONS	interacts_with	cell_type	0.70
NEURONS	regulates	cell_type	0.70
SHH	expressed_in	gene	0.70
WNT	activates	gene	0.70
STING	targets	gene	0.70
TAU	activates	gene	0.70
TAU	targets	gene	0.70
TAU	mediates	gene	0.70
STING	associated_with	gene	0.70
SHH	activates	gene	0.70
GRIN2B	associated_with	gene	0.70
LRRK2	activates	gene	0.70
DYRK1B	activates	gene	0.70
neurons	expressed_in	cell_type	0.70
CRISPR-Cas	participates_in	pathway	0.70
Ms	regulates	disease	0.65
Epilepsy	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Stroke	regulates	disease	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Asthma	treats	disease	0.65
Cancer	implicated_in	disease	0.65
Alzheimer	regulates	disease	0.65
STING	protects_against	gene	0.60
TAU	enhances	gene	0.60
WNT	regulates	gene	0.60
WNT	inhibits	gene	0.60
WNT	targets	gene	0.60
GABAERGIC	regulates	cell_type	0.60
NEURONS	activates	cell_type	0.60
STING	activates	gene	0.60
ASTROCYTES	inhibits	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
Differentiation	regulates	pathway	0.60
MTDNA	activates	gene	0.60
ATP	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
Amyloid	inhibits	pathway	0.60
Tau Phosphorylation	inhibits	pathway	0.60

Incoming (64)

Source	Relation	Type	Str
AKT	interacts_with	gene	0.70
MITOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
DMSO	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
P53	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
ROS	activates	gene	0.60
ATP	activates	gene	0.60
CRBN	activates	gene	0.60
AD	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	disease	0.60
AΒ	targets	gene	0.60
AΒ	activates	gene	0.60
ALZHEIMER'S DISEASE	markers	disease	0.60
APOPTOSIS	causes	pathway	0.60
PINK1	activates	gene	0.60
KEAP1	inhibits	gene	0.60
AKT3	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
FGFR1	associated_with	gene	0.60
RHEB	associated_with	gene	0.60
BRAF	interacts_with	gene	0.60
CDK9	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CTSB	associated_with	gene	0.60
AD	associated_with	gene	0.60
AD	regulates	gene	0.60
AD	co_discussed	gene	0.60
E2F1	regulates	gene	0.60
MYC	regulates	gene	0.60
DIABLO	regulates	gene	0.60
EGF	regulates	gene	0.60
ERK1	regulates	gene	0.60
MDM2	regulates	gene	0.60
RAF1	regulates	gene	0.60
P38	regulates	gene	0.60
AIF	regulates	gene	0.60
JNK	regulates	gene	0.60
NRAS	associated_with	gene	0.60
NF1	associated_with	gene	0.60
EGFR	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 44 hypotheses Top: 0.990

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning DYRK1A in their description or question text

No additional research found