gene

DYRK1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYRK1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

7Outgoing

10Incoming

0Experiments

0Debates

Summary

Page for DYRK1B — Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B

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🧬 Gene Info

Gene Symbol	DYRK1B
Full Name	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B
Aliases	Dual-specificity Tyrosine-Phosphorylation Regulated Kinase 1B
Chromosome	19p13.12
Protein Type	Kinase
Function	encodes a dual-specificity protein kinase belonging to the DYRK family, which phosphorylates substrates on both serine/threonine and tyrosine residues.
Primary Expression	the brain and is catalytically active at the time of translation through an intramolecular autophosphorylation mechanism
Molecular Weight	64.7 kDa
Amino Acids	629 aa
Exons	15
Pathways	Mitochondrial Function
UniProt ID	Q9Y463
NCBI Gene ID	9149
Ensembl ID	ENSG00000105204
OMIM	604556
GeneCards	DYRK1B
Human Protein Atlas	DYRK1B
Associated Diseases	neurodegeneration
Interactions	ATP, CRBN, DYRK1A, MITOCHONDRIAL DYSFUNCTION, STAT3
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DYRK1B — AlphaFold Q9Y463 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DYRK1B — Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B

gene · 1338 words

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DYRK1B Protein

protein · 1841 words

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Pathway Diagram

flowchart TD
    DYRK1B(["DYRK1B"])
    Heart_Failure["Heart Failure"]
    Fibrosis["Fibrosis"]
    Cardiac["Cardiac"]
    Mitochondrial_Function["Mitochondrial Function"]
    STAT3(["STAT3"])
    MITOCHONDRIAL_DYSFUNCTION(["MITOCHONDRIAL DYSFUNCTION"])
    neurodegeneration["neurodegeneration"]

    DYRK1B -->|"regulates"| Heart_Failure
    DYRK1B -->|"activates"| Fibrosis
    DYRK1B -->|"activates"| Cardiac
    DYRK1B -->|"regulates"| Mitochondrial_Function
    STAT3 -.->|"inhibits"| DYRK1B
    MITOCHONDRIAL_DYSFUNCTION -->|"activates"| DYRK1B
    DYRK1B -->|"implicated in"| neurodegeneration

    style DYRK1B fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (7)

Target	Relation	Type	Str
Heart Failure	regulates	disease	0.65
Fibrosis	activates	disease	0.65
Cardiac	activates	disease	0.65
neurodegeneration	associated_with	disease	0.60
SHH	expressed_in	gene	0.60
Mitochondrial Function	regulates	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
DYRK1A	activates	gene	0.70
DYRK1A	regulates	gene	0.60
DYRK1A	implicated_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
CRBN	activates	gene	0.60
ATP	activates	gene	0.60
STAT3	inhibits	gene	0.60
DYRK1A	expressed_in	gene	0.60
DYRK1A	co_expressed_with	gene	0.50
ATP	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DYRK1B in their description or question text

No additional research found