gene 824 words KG: DYRK1A
Contents

DYRK1A Gene - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A

🧬 Gene Info
Gene SymbolDYRK1A
Full NameDual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A
AliasesDYRK1A gene page, Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Chromosome21q22.13
Protein TypeSerine/Threonine Kinase
FunctionThe DYRK1A gene encodes Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A, a member of the dual-specificity tyrosine-regulated kinase (DYRK) family.
Primary Expressionindividuals with trisomy 21 (Down syndrome)
Molecular Weight85 kDa
Amino Acids754 aa
PathwaysApoptosis, Differentiation
UniProt IDQ13627
NCBI Gene ID1785
Ensembl IDENSG00000157540
OMIM600855
GeneCardsDYRK1A
Human Protein AtlasDYRK1A
Associated DiseasesAls, Alzheimer, Cancer, epilepsy
InteractionsAD, AKT, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections223 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (13)

Astrocytes
cell · KG edge: inhibits
ATP P2X3 Receptor Neurons
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Astrocytes
entity · KG edge: inhibits

Knowledge Graph (12 edges)

E2F1 regulates DYRK1A
MYC regulates DYRK1A
DIABLO regulates DYRK1A
EGF regulates DYRK1A
ERK1 regulates DYRK1A
MDM2 regulates DYRK1A
RAF1 regulates DYRK1A
P38 regulates DYRK1A
DYRK1A regulates SMAC
DYRK1A regulates AIF

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