gene

CDK9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

1Analyses

29Outgoing

11Incoming

0Experiments

1Debates

Summary

Cyclin-Dependent Kinase 9 - transcription elongation and neuronal survival

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🧬 Gene Info

Gene Symbol	CDK9
Aliases	Cyclin-Dependent Kinase 9
Protein Type	Serine/Threonine Kinase
Function	The CDK9 gene encodes Cyclin-Dependent Kinase 9, a 372-amino acid serine/threonine kinase
Primary Expression	neurons throughout the cortex, hippocampus, and basal ganglia
Subcellular Localization	s. CDK9 activity is regulated by cellular stress, growth factors, and signaling pathways
Molecular Weight	43 kDa
Amino Acids	372 aa
Ensembl ID	ENSG00000136807
GeneCards	CDK9
Human Protein Atlas	CDK9
Transcriptional Elongation	Catalytic subunit of P-TEFb; phosphorylates RNA Pol II CTD Ser2, NELF, and DSIF to enable transcription elongation[@zhou2013].
Gene Expression Control	Regulates expression of immediate-early genes, heat shock proteins, and anti-apoptotic genes.
Neuronal Survival	Protects neurons from oxidative stress and excitotoxicity through regulation of neurotrophic factor expression.
Mitochondrial Function	Regulates expression of mitochondrial genes and proteins involved in energy metabolism.
Associated Diseases	neurodegeneration
Interactions	AND, APOPTOSIS, BRD4, DNA, DYRK1A, Fus
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDK9 Gene

gene · 544 words

→

CDK9 Protein

protein · 595 words

→

Pathway Diagram

graph TD
    CDK9["CDK9"]
    Als{"Als"}
    CDK9 -->|"activates"| Als
    CDK9 -->|"regulates"| Als
    ALS{"ALS"}
    CDK9 -->|"activates"| ALS
    DNA["DNA"]
    CDK9 -->|"activates"| DNA
    TBX3["TBX3"]
    CDK9 -->|"regulates"| TBX3
    TCF3["TCF3"]
    CDK9 -->|"regulates"| TCF3
    AND["AND"]
    CDK9 -->|"activates"| AND
    neurodegeneration["neurodegeneration"]
    CDK9 -->|"implicated in"| neurodegeneration
    MYC["MYC"]
    MYC -->|"regulates"| CDK9
    DNA -->|"activates"| CDK9
    style CDK9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
POLR2A	interacts_with	gene	0.85
DNA damage response	mediates	process	0.80
CTD_phosphorylation	regulates	process	0.70
POLR2A_CTD_phosphorylation	regulates	process	0.70
ALS	activates	disease	0.65
Als	activates	disease	0.65
Als	regulates	disease	0.65
Lymphoma	inhibits	disease	0.65
Ras	phosphorylates	protein	0.60
Fus	inhibits	protein	0.60
RNA	inhibits	gene	0.60
Ras	activates	protein	0.60
GAIN	inhibits	gene	0.60
DYRK1A	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
DNA	activates	gene	0.60
DNA	associated_with	gene	0.60
RNA	associated_with	gene	0.60
Apoptosis	inhibits	pathway	0.60
DNA	phosphorylates	gene	0.60
RNA	phosphorylates	gene	0.60
AND	phosphorylates	gene	0.60
GENES	inhibits	gene	0.60
RNA	activates	gene	0.60
YTHDF2	regulates	gene	0.60
B Cell	inhibits	cell_type	0.60
TBX3	regulates	gene	0.60
TCF3	regulates	gene	0.60
B Cell	expressed_in	cell_type	0.55

Incoming (11)

Source	Relation	Type	Str
MYC	regulates	gene	0.60
GAIN	inhibits	gene	0.60
DNA	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
DNA	phosphorylates	gene	0.60
RNA	phosphorylates	gene	0.60
GENES	inhibits	gene	0.60
AND	phosphorylates	gene	0.60
BRD4	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do dilncRNAs specifically drive molecular crowding and phase separation of D

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into

closed · Rounds: 7 · Score: 0.90 · 2026-04-10

Related Research

Hypotheses and analyses mentioning CDK9 in their description or question text

No additional research found