gene

LRRK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRRK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

22Outgoing

9Incoming

0Experiments

0Debates

Summary

Page for LRRK1 - Leucine-Rich Repeat Kinase 1

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	LRRK1
Full Name	Leucine-Rich Repeat Kinase 1
Aliases	Page for LRRK1, Page for LRRK1 Protein
Chromosome	15q26.3
Protein Type	Kinase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various tissues including the brain, with particularly high expression in osteoclasts and neurons
Molecular Weight	230 kDa
Amino Acids	023 aa
UniProt ID	[Q8IWU6](https://www.uniprot.org/uniprot/Q8IWU6)
Ensembl ID	ENSG00000153902
GeneCards	LRRK1
Human Protein Atlas	LRRK1
Serine/threonine kinase activity	Autophosphorylation and substrate phosphorylation
GTPase activity	ROC domain binds and hydrolyzes GTP
Associated Diseases	ALS, Parkinson, Parkinson's disease
Interactions	AND, App, DYRK1A, EGF, GAIN, LRRK2
KG Connections	31 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LRRK1 - Leucine-Rich Repeat Kinase 1

gene · 771 words

→

LRRK1 Protein - Leucine-Rich Repeat Kinase 1

protein · 641 words

→

Pathway Diagram

graph TD
    LRRK1["LRRK1"]
    Parkinson{"Parkinson"}
    LRRK1 -->|"interacts with"| Parkinson
    Als{"Als"}
    LRRK1 -->|"interacts with"| Als
    LRRK2["LRRK2"]
    LRRK1 -->|"inhibits"| LRRK2
    neurodegeneration["neurodegeneration"]
    LRRK1 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| LRRK1
    style LRRK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
ALS	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
PARKINSON	interacts_with	gene	0.60
App	interacts_with	protein	0.60
ALS	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Parkinson's disease	implicated_in	disease	0.60
Parkinson's disease	regulates	disease	0.60
LRRK2	interacts_with	gene	0.60
LRRK2	inhibits	gene	0.60
GAIN	interacts_with	gene	0.60
LRRK2	implicated_in	gene	0.60
LRRK2	activates	gene	0.60
LRRK2	regulates	gene	0.60
LRRK2	phosphorylates	gene	0.60
MST1	phosphorylates	gene	0.60
TBK1	phosphorylates	gene	0.60
TBK1	associated_with	gene	0.60
AND	inhibits	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
PPM1H	co_expressed_with	protein	0.50

Incoming (9)

Source	Relation	Type	Str
AND	inhibits	gene	0.60
PARKINSON	interacts_with	gene	0.60
LRRK2	inhibits	gene	0.60
GAIN	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
EGF	inhibits	gene	0.60
EGF	activates	gene	0.60
DYRK1A	phosphorylates	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRRK1 in their description or question text

No additional research found