gene

GRIN2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIN2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

196Connections

9Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

20Debates

Summary

GRIN2B is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, co discussed. Associated with ALS, Als, Alzheimer. Connected to 70 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GRIN2B
Full Name	NMDA Receptor Subunit 2B
Protein Type	Gene
Function	The GRIN2B subunit contributes to the unique pharmacological and biophysical properties of NMDA receptors
Primary Expression	Prefrontal Cortex, Cortex, Ventral Tegmental Area, Substantia Nigra
Pathways	Circadian Rhythm, Calcium Signaling, Epigenetic, synaptic plasticity
GeneCards	GRIN2B
Human Protein Atlas	GRIN2B
Calcium Permeability	NMDA receptors containing GRIN2B have high calcium permeability, enabling calcium-dependent signaling cascades essential for synaptic plasticity[@paoletti2013]
Slower Kinetics	GRIN2B-containing receptors have slower deactivation kinetics compared to GRIN2A-containing receptors
Developmental Regulation	GRIN2B expression peaks early in development and decreases with age as GRIN2A expression increases
Synaptic Localization	GRIN2B is primarily found at extrasynaptic and immature synapses
Synaptic Dysfunction	Aβ oligomers directly interact with NMDA receptors, causing internalization and impairment of glutamatergic signaling[@liu2021]
Excitotoxicity	Overactivation of NMDA receptors contributes to dopaminergic neuron death
Memory Deficits	NMDA receptor hypofunction, particularly involving GRIN2B, correlates with cognitive deficits in AD
Associated Diseases	Als, Alzheimer, Bipolar, Bipolar Disorder, Depression
Interactions	Albumin, DAO, DISC1, G72, GRM3, GRM4
SciDEX Hypotheses	GluN2B-Mediated Thalamocortical Control of Glympha Thalamocortical Synchrony Restoration via NMDA Mod Cortico-Striatal Synchrony Restoration via NMDA Mo (+6 more)
KG Connections	196 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    GRIN2B["GRIN2B"] -->|"associated with"| Schizophrenia["Schizophrenia"]
    GRIN2B["GRIN2B"] -->|"associated with"| Als["Als"]
    GRIN2B["GRIN2B"] -->|"associated with"| Depression["Depression"]
    GRIN2B["GRIN2B"] -->|"associated with"| Bipolar["Bipolar"]
    GRIN2B["GRIN2B"] -->|"associated with"| Ms["Ms"]
    GRIN2B["GRIN2B"] -->|"associated with"| Alzheimer["Alzheimer"]
    GRIN2B["GRIN2B"] -->|"associated with"| Inflammation["Inflammation"]
    GRIN2B["GRIN2B"] -->|"associated with"| ALS["ALS"]
    DLG4["DLG4"] -->|"associated with"| GRIN2B["GRIN2B"]
    GRIN2B["GRIN2B"] -->|"associated with"| DRD1["DRD1"]
    GRIN2B["GRIN2B"] -->|"associated with"| TPH2["TPH2"]
    GRIN2B["GRIN2B"] -->|"associated with"| GABRA5["GABRA5"]
    style GRIN2B fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Schizophrenia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Bipolar fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style DLG4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style DRD1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style TPH2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GABRA5 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (110)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN2B	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
thalamocortical_synchrony	modulates	pathway	0.75
MAPT	regulates	gene	0.70
PLP1	regulates	gene	0.70
IDE	regulates	gene	0.70
PSEN2	regulates	gene	0.70
SNAP25	associated_with	gene	0.70
SYT1	associated_with	gene	0.70
RELN	associated_with	gene	0.70
VAMP2	associated_with	gene	0.70
SYN1	associated_with	gene	0.70
IBA1	regulates	gene	0.70
SQSTM1	associated_with	gene	0.70
PSEN1	associated_with	gene	0.70
Bipolar Disorder	associated_with	disease	0.70
ALS	associated_with	disease	0.65
ALS	activates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
BMAL1	associated_with	gene	0.60
Dopaminergic	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
IGF1	regulates	gene	0.60
DRD1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
GNA13	associated_with	gene	0.60
GNAI1	associated_with	gene	0.60
GNA12	associated_with	gene	0.60
Circadian Rhythm	associated_with	pathway	0.60
Calcium Signaling	associated_with	pathway	0.60
PDLIM5	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
NCAM1	interacts_with	gene	0.60
NRG1	interacts_with	gene	0.60
RGS4	interacts_with	gene	0.60
SYNGR1	interacts_with	gene	0.60
GRM3	interacts_with	gene	0.60
GRM4	interacts_with	gene	0.60

Incoming (86)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN2B	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
h-var-e2b5a7e7db	targets_gene	hypothesis	0.90
h-cd60e2ec	targets	hypothesis	0.90
h-var-5e33600319	targets_gene	hypothesis	0.90
GRIN1	expresses	gene	0.70
DYRK1A	associated_with	gene	0.70
GRIN1	regulates	gene	0.70
APP	regulates	gene	0.70
GFAP	regulates	gene	0.70
ATG7	regulates	gene	0.70
AIF1	regulates	gene	0.70
DLG4	associated_with	gene	0.65
PDLIM5	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
AD	regulates	gene	0.60
AUTOPHAGY	regulates	pathway	0.60
AΒ	regulates	gene	0.60
AD	associated_with	gene	0.60
DLG4	regulates	gene	0.60
DNA	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
GLUTAMATERGIC	associated_with	cell_type	0.60
GRIN2A	causes	gene	0.60
GRIN1	associated_with	gene	0.60
GRIN2A	associated_with	gene	0.60
SLC17A7	expressed_in	gene	0.60
NR2B	regulates	gene	0.60
PSD95	regulates	gene	0.60
FOS	regulates	gene	0.60
NPAS4	regulates	gene	0.60
AD	co_discussed	gene	0.60
GRID1	expressed_in	gene	0.60
DAO	interacts_with	gene	0.60
SYNGR1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
BIPOLAR	associated_with	disease	0.60
GENES	regulates	gene	0.60
C-FOS	regulates	gene	0.60
G72	interacts_with	gene	0.60
NCAM1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
KCNN3	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
POLG	associated_with	gene	0.60

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cl	0.964	neuroscience	Circuit-level neural dynamics in neurode
Thalamocortical Synchrony Restoration via NMDA Modulation	0.743	neuroscience	Circuit-level neural dynamics in neurode
Cortico-Striatal Synchrony Restoration via NMDA Modulation	0.723	neuroscience	Circuit-level neural dynamics in neurode
Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau	0.620	neurodegeneration	Investigate prion-like spreading of tau
GluN2B-Mediated Microglial Activation and Tau Propagation	0.565	neuroscience	Circuit-level neural dynamics in neurode

Ketone-Primed Thalamocortical Enhancement of Glymphatic Tau	0.565	neuroscience	Circuit-level neural dynamics in neurode
GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates v	0.491	neuroscience	Circuit-level neural dynamics in neurode
GluN2B-Mediated Perivascular Pericyte Control of Glymphatic	0.485	neuroscience	Circuit-level neural dynamics in neurode
GluN2B-Mediated Microglial Activation and Tau Phagocytosis	0.380	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (2)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.779

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 70 hypotheses Top: 0.964

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Inspired by molecular dynamic simulation, exploring chemical constituents of alc [PMID:40166865]	Shinge J, Muthal A, Walhekar V, Bagul C,	Journal of biomolecular struct	2026
Cognitive loss after brain trauma results from sex-specific activation of synapt [PMID:40796363]	Arizanovska D, Bush GF, Dallera CA, Folo	Brain	2026
Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil. [PMID:40994429]	Banke TG, Regan MC, Perszyk RE, Zhang L,	Brain	2026
GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and beha [PMID:41512078]	Ge Y, Tian T, Li B, Axerio-Cillies P, Ch	Sci Adv	2026
Zipper-interacting Protein Kinase Modulates Gene Expression Linked to Synaptic a [PMID:41526727]	Mei Y, Zheng L, He M, Wang L, Zhou Y et	Mol Neurobiol	2026
Multi-biofluid metabolomics coupled with gene network reveals stage-specific alt [PMID:41534821]	Cadaxo AS, Cotrin JC, Valente AP, Lopes	Brain Res	2026
Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mi [PMID:41675057]	Farsi Z, Nicolella A, Simmons SK, Shin W	iScience	2026
From synapse to system: mechanistic pathways of neural signaling dysfunction in [PMID:41799440]	Gupta R, Jha NK, Kumar N, Nagraik R, Rav	Front Cell Dev Biol	2026
Multisession epidural direct current stimulation of the auditory cortex mitigate [PMID:41747412]	Fernández Del Campo IS, Cebrián-León A,	Hearing research	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neuropathology of incidental Lewy body & prodromal Parkinson's disease. [PMID:37173733]	Koeglsperger T, Rumpf SL, Schließer P, S	Molecular neurodegeneration	2023
Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ. [PMID:35379353]	Unknown	Acta Neuropathol Commun	2022
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurod [PMID:33603230]	Dong Y, D'Mello C, Pinsky W, Lozinski BM	Nature neuroscience	2021
Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA re [PMID:31085626]	Unknown	EMBO Rep	2019
Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of N [PMID:24761931]	Unknown	Mol Brain	2014
Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyt [PMID:15212844]	Unknown	Neurobiol Aging	2004

Debates (20)

Multi-agent debates referencing this entity

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

closed · Rounds: 4 · Score: 0.65 · 2026-04-27

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

closed · Rounds: 4 · Score: 0.71 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

closed · Rounds: 4 · Score: 0.87 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

closed · Rounds: 4 · Score: 0.54 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac

closed · Rounds: 4 · Score: 0.19 · 2026-04-27

Hypothesis debate: Closed-loop transcranial alternating current stimulation to r

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Related Research

Hypotheses and analyses mentioning GRIN2B in their description or question text