gene

ESRRA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESRRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

17Outgoing

6Incoming

0Experiments

0Debates

Summary

ESRRA is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Alzheimer's disease, Inflammation, neurodegenerative disease. Connected to 16 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ESRRA
Full Name	ESRRA (Estrogen-Related Receptor Alpha)
Chromosome	11q13.1
Protein Type	Gene
Function	PGC-1α coactivates ERRα, which in turn drives the expression of nuclear-encoded mitochondrial genes - OXPHOS Regulation: Controls the expression of all five complex subunits of the electron transport
Primary Expression	tissues with high energy demands, including the brain, heart, skeletal muscle, and liver[2]
Amino Acids	500 aa
Exons	8
Pathways	Microbiota
GeneCards	ESRRA
Human Protein Atlas	ESRRA
N-terminal activation domain	Contains the AF-1 region for transcriptional activation
DNA-binding domain (DBD)	Two zinc finger motifs that recognize estrogen-related response elements (ERREs)
Hinge region	Flexible region allowing protein-protein interactions
Ligand-binding domain (LBD)	Contains the AF-2 activation domain; despite being an orphan receptor, it maintains a functional LBD capable of binding synthetic ligands
Associated Diseases	Alzheimer's disease
Interactions	ATG5, AUTOPHAGY, MITOPHAGY, PINK1, PTEN
KG Connections	23 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ESRRA (Estrogen-Related Receptor Alpha) Gene

gene · 1152 words

→

Pathway Diagram

graph TD
    ESRRA["ESRRA"]
    DKK1["DKK1"]
    ESRRA -->|"regulates"| DKK1
    Alzheimer_s_disease{"Alzheimer's disease"}
    ESRRA -->|"associated with"| Alzheimer_s_disease
    neurodegenerative_disease{"neurodegenerative disease"}
    ESRRA -->|"regulates"| neurodegenerative_disease
    PTEN["PTEN"]
    ESRRA -->|"activates"| PTEN
    AUTOPHAGY["AUTOPHAGY"]
    ESRRA -->|"activates"| AUTOPHAGY
    PINK1["PINK1"]
    ESRRA -->|"activates"| PINK1
    ATG5["ATG5"]
    ESRRA -->|"activates"| ATG5
    Autophagy(["Autophagy"])
    ESRRA -->|"activates"| Autophagy
    Mitophagy(["Mitophagy"])
    ESRRA -->|"activates"| Mitophagy
    neurodegeneration["neurodegeneration"]
    ESRRA -->|"implicated in"| neurodegeneration
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| ESRRA
    style ESRRA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
ATG5	upregulates	gene	0.90
DKK1	regulates	gene	0.70
neurodegenerative disease	regulates	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
Inflammation	regulates	disease	0.65
INFLAMMATION	regulates	gene	0.60
Microbiota	regulates	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Autophagy	associated_with	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
AND	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PTEN	activates	gene	0.60
PINK1	activates	gene	0.60
ATG5	activates	gene	0.60

Incoming (6)

Source	Relation	Type	Str
ATG5	associated_with	gene	0.70
ATG5	activates	gene	0.60
ATG5	expressed_in	gene	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
INFLAMMATION	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ESRRA in their description or question text

No additional research found