gene

NESTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NESTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

164Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

0Experiments

0Debates

Summary

NESTIN is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, inhibits. Associated with ALS, Als, Alzheimer. Connected to 106 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NESTIN
Chromosome	1q23.1
Protein Family	Class VI intermediate filaments
Function	is a protein encoded by the NES gene.
Primary Expression	neural stem and progenitor cells during development and in adult neurogenic regions[@reynolds1992]:
Subcellular Localization	Cytoplasm, intermediate filaments
Molecular Weight	220 kDa
Amino Acids	4477 aa
Pathways	Circadian Rhythm, Mapk, Mitochondrial Function, Wnt
UniProt ID	P48681
NCBI Gene ID	4756
Ensembl ID	ENSG00000132688
GeneCards	NESTIN
Human Protein Atlas	NESTIN
N-terminal head domain	Highly charged, involved in protein-protein interactions
Associated Diseases	Neurodevelopmental disorders, Brain tumors, Alzheimer's disease, Parkinson's disease, Stroke
Interactions	AKT, ALDH1L1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ARC
KG Connections	164 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NESTIN — AlphaFold P48681 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NESTIN: Intermediate Filament Protein in Neural Stem Cells and Neurodegeneration

gene · 1827 words

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Pathway Diagram

graph TD
    NESTIN["NESTIN"]
    NESTIN -->|"expressed in"| Als["Als"]
    NESTIN -->|"activates"| Ischemia["Ischemia"]
    NESTIN -->|"interacts"| Alzheimer["Alzheimer"]
    NESTIN -->|"interacts"| Ms["Ms"]
    NESTIN -->|"activates"| Cardiovascular["Cardiovascular"]
    NESTIN -->|"activates"| Depression["Depression"]
    SOX2["SOX2"] -->|"expressed in"| NESTIN
    EGF["EGF"] -->|"expressed in"| NESTIN
    GFAP["GFAP"] -->|"expressed in"| NESTIN
    DLK2["DLK2"] -->|"expressed in"| NESTIN
    ALDH1L1["ALDH1L1"] -->|"expressed in"| NESTIN
    GENES["GENES"] -->|"expressed in"| NESTIN
    NGF["NGF"] -->|"activates"| NESTIN
    DCX["DCX"] -->|"activates"| NESTIN
    BDNF["BDNF"] -->|"activates"| NESTIN
    HES1["HES1"] -->|"activates"| NESTIN

Outgoing (121)

Target	Relation	Type	Str
NEURODEGENERATIVE DISEASES	involved_in	disease	0.85
Als	activates	disease	0.75
Ischemia	activates	disease	0.75
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Autoimmune	inhibits	disease	0.65
Autism	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Cardiovascular	activates	disease	0.65
Stroke	activates	disease	0.65
Als	expressed_in	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
ALS	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Obesity	activates	disease	0.65
Ms	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Ms	interacts_with	disease	0.65
NOTCH1	expressed_in	gene	0.60
DLK2	expressed_in	gene	0.60
SOX2	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
VIMENTIN	expressed_in	gene	0.60
SOX2	associated_with	gene	0.60
EGF	activates	gene	0.60
TUBULIN	activates	gene	0.60
SOX10	activates	gene	0.60
GDNF	activates	gene	0.60
FGF2	activates	gene	0.60
SOX2	activates	gene	0.60
CHAT	activates	gene	0.60
MEF2C	expressed_in	gene	0.60
Neurogenesis	inhibits	pathway	0.60
Notch	inhibits	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Differentiation	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
Lipid Metabolism	inhibits	pathway	0.60
Neuron	activates	cell_type	0.60
GENES	expressed_in	gene	0.60
ALDH1L1	expressed_in	gene	0.60

Incoming (43)

Source	Relation	Type	Str
ASTROCYTES	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
SOX2	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ERK	inhibits	gene	0.60
BCL-2	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
DEMENTIA	expressed_in	gene	0.60
NGF	activates	gene	0.60
DCX	activates	gene	0.60
BDNF	activates	gene	0.60
HES1	activates	gene	0.60
BRAF	expressed_in	gene	0.60
MET	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
PI3K	activates	gene	0.60
PROGRANULIN	expressed_in	gene	0.60
AND	activates	gene	0.60
VIMENTIN	expressed_in	gene	0.60
SP1	activates	gene	0.60
DKK1	inhibits	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
SYNAPSE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
RAS	activates	gene	0.60
STROKE	activates	gene	0.60
NOTCH	expressed_in	gene	0.60
ALDH1L1	inhibits	gene	0.60
DLK2	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
SOX2	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
WNT	regulates	gene	0.60
MAPK	regulates	gene	0.60
DLK2	expressed_in	gene	0.60
ALDH1L1	expressed_in	gene	0.60
AKT	inhibits	gene	0.60
ARC	inhibits	gene	0.60
NOTCH1	expressed_in	gene	0.60
STAT3	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NESTIN in their description or question text

No additional research found