concept

LYSOSOMAL FUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMAL FUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

1Hypotheses

4Analyses

3Outgoing

34Incoming

0Experiments

4Debates

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💡 Concept Info

Name	LYSOSOMAL FUNCTION

Pathway Diagram

graph TD
    LYSOSOMAL_FUNCTION["LYSOSOMAL FUNCTION"]
    LYSOSOMAL_FUNCTION -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    TFEB["TFEB"] -->|"activates"| LYSOSOMAL_FUNCTION
    CKLF["CKLF"] -->|"inhibits"| LYSOSOMAL_FUNCTION
    AMPK["AMPK"] -->|"regulates"| LYSOSOMAL_FUNCTION
    TREM2["TREM2"] -->|"regulates"| LYSOSOMAL_FUNCTION
    Lyso_ChR2["Lyso-ChR2"] -->|"modulates"| LYSOSOMAL_FUNCTION
    APOE4["APOE4"] -->|"inhibits"| LYSOSOMAL_FUNCTION
    TMEM175["TMEM175"] -->|"regulates"| LYSOSOMAL_FUNCTION

Outgoing (3)

Target	Relation	Type	Str
Alzheimer's Disease	involved_in	disease	0.90
Vandetanib-Induced Hepato-Cardiotoxicity	protects_against	phenotype	0.85
tau pathology	involved_in	phenotype	0.70

Incoming (34)

Source	Relation	Type	Str
TFEB	activates	gene	0.95
Palmitic acid	associated_with	compound	0.95
GRN	involved_in	gene	0.95
WDR91	regulates	protein	0.95
APOE4	inhibits	protein	0.90
Urolithin A	associated_with	compound	0.90
pH disruption	associated_with	process	0.90
Urolithin A	associated_with	chemical	0.90
CTSD	regulates	gene	0.90
CKLF	inhibits	protein	0.90
AMPK	regulates	protein	0.90
TREM2	regulates	gene	0.90
Lyso-ChR2	modulates	protein	0.90
WDR91	regulates	protein	0.90
TFEB	regulates	protein	0.88
Lyso-Chr2	regulates	protein	0.87
LRRK2 Inhibitors	treats	drug	0.85
Lrrk2 Inhibitors	associated_with	drug	0.80
MS4A4A	inhibits	gene	0.80
APOE4	associated_with	gene	0.80
TREM2	enhances	gene	0.75
LRRK2	modulates	protein	0.75
TMEM175	regulates	protein	0.75
TRPML1 agonists	therapeutic_target_for	drug	0.70
TFEB	regulates	protein	0.70
CTSZ	regulates	protein	0.70
Aβ accumulation	inhibits	process	0.70
APOE4	inhibits	protein	0.70
APOE4	impairs	gene	0.70
TMT	inhibits	drug	0.70
Urolithin A	restores	compound	0.70
APOE4	disrupts	gene	0.70
RAB8A	regulates	protein	0.70
TMEM106B	modulates	protein	0.70