concept

ENDOCYTOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOCYTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

688Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ENDOCYTOSIS is a concept in neurodegeneration research. Key relationships include: activates, co discussed, degrades. Connected to 18 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ENDOCYTOSIS
Key Genes/Proteins	ABCA1, APOE, BMAL1, C1Q, CAV1, CLOCK

Pathway Diagram

graph TD
    ENDOCYTOSIS["ENDOCYTOSIS"]
    ENDOCYTOSIS -->|"activates"| MTORC1["MTORC1"]
    ENDOCYTOSIS -->|"interacts"| Complement["Complement"]
    ENDOCYTOSIS -->|"interacts"| Exocytosis["Exocytosis"]
    ENDOCYTOSIS -->|"interacts"| Angiogenesis["Angiogenesis"]
    ENDOCYTOSIS -->|"interacts"| Apoptosis["Apoptosis"]
    ENDOCYTOSIS -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    ENDOCYTOSIS -->|"interacts"| Autophagy["Autophagy"]
    TFEB["TFEB"] -->|"activates"| ENDOCYTOSIS
    PIEZO1["PIEZO1"] -->|"activates"| ENDOCYTOSIS
    TARDBP["TARDBP"] -->|"expressed in"| ENDOCYTOSIS
    NTN1["NTN1"] -->|"expressed in"| ENDOCYTOSIS
    SNRNP70["SNRNP70"] -->|"expressed in"| ENDOCYTOSIS
    JUN["JUN"] -->|"expressed in"| ENDOCYTOSIS
    NTN3["NTN3"] -->|"expressed in"| ENDOCYTOSIS

Outgoing (71)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Lysosomes	involved_in	cell_type	0.95
Target Degradation	mediates	process	0.90
MTORC1	activates	protein	0.90
target protein degradation	mediates	process	0.90
MTORC1	activates	protein	0.90
MTORC1 Signaling	mediates	pathway	0.90
Signal Amplification	contributes_to	mechanism	0.90
Signal Amplification	mediates	process	0.85
Tau Pathology Propagation	mediates	process	0.85
Alzheimer's Disease	associated_with	disease	0.85
Alzheimer Disease	associated_with	disease	0.85
Protein Degradation	contributes_to	process	0.85
Casm	activates	process	0.80
Protein Degradation	promotes	process	0.80
extracellular Tau accumulation	regulates	process	0.70
MTORC1	activates	protein	0.64
PICALM	associated_with	gene	0.60
TFEB	activates	gene	0.60
PIEZO1	activates	gene	0.60
TLR4	regulates	gene	0.60
FLOT1	associated_with	gene	0.60
HLA-DRB1	associated_with	gene	0.60
RNA	activates	gene	0.60
RNA	binds_to	gene	0.60
MAF	activates	gene	0.60
Phagocytosis	interacts_with	pathway	0.55
Tgf-Β	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Exocytosis	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Exocytosis	associated_with	pathway	0.50
Endothelial Cell	regulates	cell_type	0.50
ENDOTHELIAL	regulates	concept	0.50
ISCHEMIC	regulates	concept	0.50
ISCHEMIC STROKE	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
Endothelial Cell	interacts_with	cell_type	0.50
ENDOTHELIAL	interacts_with	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
STEM CELLS	interacts_with	concept	0.50
EXTRACELLULAR VESICLES	interacts_with	concept	0.50
ENDOSOMES	regulates	concept	0.50
GLUTAMATE	associated_with	concept	0.50

Incoming (617)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
Cancer	therapeutic_target	disease	1.00
Designed Endocytosis-Inducing Proteins	associated_with	protein	0.95
Lysosomes	involved_in	cell_type	0.95
TFEB	upregulates	gene	0.95
Designed Endocytosis-Inducing Proteins	activates	protein	0.95
FLOT1	involved_in	protein	0.95
TFEB	associated_with	protein	0.90
Designed Endocytosis-Inducing Proteins	involved_in	protein	0.90
Extracellular α-Synuclein Fibrils	involved_in	protein	0.90
Extracellular Α-Synuclein Fibrils	involved_in	compound	0.90
CANCER	therapeutic_target	gene	0.90
SCN9A	involved_in	gene	0.88
Annexins	involved_in	protein	0.85
BIN1	involved_in	protein	0.85
TFRC	mediates	protein	0.85
BIN1 Loss	upregulates	mechanism	0.85
EPSIN1	involved_in	protein	0.85
EPSIN2	involved_in	protein	0.85
Dopamine D3 Receptor	mediates	receptor	0.85
SNCA	involved_in	protein	0.85
SNCA aggregation	associated_with	process	0.80
ANNEXINS	involved_in	protein	0.80
Als	therapeutic_target	disease	0.80
Alzheimer	therapeutic_target	disease	0.80
Tumor	therapeutic_target	disease	0.80
AUTOPHAGY	associated_with	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
MTOR	modulates	pathway	0.78
TFEB	activates	protein	0.72
EGF	activates	gene	0.70
AMYLOID	interacts_with	gene	0.70
LC3	associated_with	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
LYSOSOME	activates	gene	0.70
Als	activates	disease	0.70
COMPLEMENT	regulates	gene	0.70
CANCER	regulates	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
Als	regulates	disease	0.70
PHAGOCYTOSIS	associated_with	gene	0.70
CTSD	part_of	gene	0.70
ROS	therapeutic_target	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
DNA	therapeutic_target	gene	0.70
TAU	inhibits	gene	0.70
Alzheimer	associated_with	disease	0.70
Als	inhibits	disease	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasom	0.617	neurodegeneration	How do perivascular cells specifically r
Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri	0.406	molecular biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity