gene

LRP6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

LRP6 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Als, Alzheimer. Connected to 70 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LRP6
Chromosome	12p13.2
Protein Type	Receptor
Function	Wnt ligand binds to LRP6 extracellular domain
Molecular Weight	180 kDa
Pathways	signaling: Canonical Pathway Activation:, Wnt, Wnt signaling
UniProt ID	O75151
NCBI Gene ID	4040
Ensembl ID	ENSG00000170054
GeneCards	LRP6
Human Protein Atlas	LRP6
Associated Diseases	ALS
Interactions	AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections	102 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LRP6 — AlphaFold O75151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LRP6["LRP6"]
    cardiac_hypertrophy{"cardiac hypertrophy"}
    LRP6 -->|"protects against"| cardiac_hypertrophy
    HSP90_["HSP90alpha"]
    LRP6 -->|"interacts with"| HSP90_
    CTSD["CTSD"]
    LRP6 -->|"interacts with"| CTSD
    LRP6 -->|"activates"| CTSD
    Atherosclerosis{"Atherosclerosis"}
    LRP6 -->|"regulates"| Atherosclerosis
    Cardiovascular{"Cardiovascular"}
    LRP6 -->|"regulates"| Cardiovascular
    Als{"Als"}
    LRP6 -->|"regulates"| Als
    Fibrosis{"Fibrosis"}
    LRP6 -->|"activates"| Fibrosis
    LRP6 -->|"activates"| Als
    Cardiac{"Cardiac"}
    LRP6 -->|"inhibits"| Cardiac
    Heart_Failure{"Heart Failure"}
    LRP6 -->|"activates"| Heart_Failure
    Ms{"Ms"}
    LRP6 -->|"activates"| Ms
    LRP5["LRP5"]
    LRP5 -->|"associated with"| LRP6
    CTSD -->|"inhibits"| LRP6
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP6
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| LRP6
    DVL1["DVL1"]
    DVL1 -->|"interacts with"| LRP6
    AKT1["AKT1"]
    AKT1 -->|"activates"| LRP6
    CANCER["CANCER"]
    CANCER -->|"activates"| LRP6
    RBPJ["RBPJ"]
    RBPJ -->|"regulates"| LRP6
    APOE["APOE"]
    APOE -->|"contributes to"| LRP6
    LDLR -->|"contributes to"| LRP6
    style LRP6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

Target	Relation	Type	Str
cardiac hypertrophy	protects_against	disease	0.90
Wnt/β-catenin signaling	involved_in	pathway	0.90
CTSD	activates	protein	0.80
HSP90α	interacts_with	protein	0.80
CTSD	interacts_with	protein	0.80
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cardiovascular	regulates	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Als	contributes_to	disease	0.65
Metabolic Syndrome	contributes_to	disease	0.65
Cardiovascular	contributes_to	disease	0.65
Atherosclerosis	contributes_to	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Als	activates	disease	0.65
Cardiac	inhibits	disease	0.65
Heart Failure	activates	disease	0.65
LRP5	associated_with	gene	0.60
HDAC	expressed_in	gene	0.60
AND	associated_with	gene	0.60
WNT	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
stem cells	expressed_in	cell_type	0.60
Wnt	interacts_with	pathway	0.60
Cholesterol	contributes_to	pathway	0.60
Endothelial	regulates	cell_type	0.60
Macrophage	regulates	cell_type	0.60
neurons	expressed_in	cell_type	0.60
WNT3A	inhibits	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Akt	activates	pathway	0.60
Notch	regulates	pathway	0.60
Wnt	associated_with	pathway	0.60
LDLR	associated_with	gene	0.60
NOTCH1	regulates	gene	0.60
APP	activates	gene	0.60
AKT	activates	gene	0.60
Endocytosis	regulates	pathway	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60

Incoming (32)

Source	Relation	Type	Str
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID	activates	gene	0.60
WNT3A	inhibits	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
LDL	associated_with	gene	0.60
LRP5	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	interacts_with	gene	0.60
HDAC	expressed_in	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
WNT	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
LRP5	interacts_with	gene	0.60
AKT1	activates	gene	0.60
RBPJ	regulates	gene	0.60
APOE	contributes_to	gene	0.60
AND	associated_with	gene	0.60
CTSD	inhibits	gene	0.60
CANCER	activates	gene	0.60
DVL1	interacts_with	gene	0.60
WNT3A	therapeutic_target	gene	0.60
LRP5	activates	gene	0.60
ALZHEIMER	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50
LDLR	co_expressed_with	gene	0.50
LDLR	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRP6 in their description or question text

No additional research found