Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Proteostasis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Proteostasis |
| Key Genes/Proteins | ACTB, AGING, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE |
| Related Diseases | aging, Aging, Als, Alzheimer, Alzheimer Disease |
| Related Pathways | Ampk |
| Linked Hypotheses | 5 hypotheses |
Knowledge base pages for this entity
graph TD
SYNCRIP["SYNCRIP"] -->|"associated"| Proteostasis["Proteostasis"]
Ubiquitin_Proteasome_System["Ubiquitin-Proteasome System"] -->|"involved in"| Proteostasis["Proteostasis"]
RNA_Binding_Protein["RNA Binding Protein"] -->|"involved in"| Proteostasis["Proteostasis"]
METTL3["METTL3"] -->|"modulates"| Proteostasis["Proteostasis"]
style Proteostasis fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cellular Aging | regulates | process | 0.82 |
| Alzheimer's Disease | involved_in | disease | 0.80 |
| Amyotrophic Lateral Sclerosis | involved_in | disease | 0.80 |
| Cellular Aging | modulates | process | 0.75 |
| pathological conditions | protects_against | disease | 0.70 |
| TAU | activates | protein | 0.70 |
| NEURODEGENERATION | causes | phenotype | 0.70 |
| TAU | treats | protein | 0.70 |
| TAU | interacts_with | gene | 0.65 |
| UBIQUITIN | stabilizes | gene | 0.60 |
| AGING | transports | phenotype | 0.60 |
| APOE | treats | gene | 0.60 |
| SEEDING | co_discussed | entity | 0.50 |
| GENE EXPRESSION | interacts_with | concept | 0.50 |
| SLEEP | co_discussed | entity | 0.50 |
| SYNCRIP | interacts_with | concept | 0.50 |
| Cellular Senescence | regulates | cell_type | 0.50 |
| TFEB | co_discussed | entity | 0.50 |
| BORTEZOMIB | associated_with | drug | 0.50 |
| T CELLS | co_discussed | entity | 0.50 |
| VCP | co_discussed | entity | 0.50 |
| ADUCANUMAB | associated_with | drug | 0.50 |
| α-SYNUCLEIN | regulates | concept | 0.50 |
| Cellular Senescence | interacts_with | cell_type | 0.50 |
| Protein Folding | associated_with | pathway | 0.50 |
| ENDOPLASMIC RETICULUM | associated_with | concept | 0.50 |
| DENDRITE | associated_with | concept | 0.50 |
| Protein Folding | regulates | pathway | 0.50 |
| Proteins | activates | protein | 0.50 |
| CHRONIC INFLAMMATION | regulates | concept | 0.50 |
| GENE EXPRESSION | activates | concept | 0.50 |
| LECANEMAB | associated_with | drug | 0.50 |
| SYNUCLEIN | regulates | concept | 0.50 |
| UNFOLDED PROTEIN RESPONSE | co_discussed | entity | 0.50 |
| T CELL | co_discussed | entity | 0.50 |
| TAU | co_discussed | entity | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| EXTRACELLULAR MATRIX | interacts_with | concept | 0.50 |
| EXTRACELLULAR MATRIX | associated_with | concept | 0.50 |
| STAT3 | co_discussed | entity | 0.50 |
| SYNAPTIC PLASTICITY | co_discussed | entity | 0.50 |
| SYNAPSE | co_discussed | entity | 0.50 |
| TDP-43 | co_discussed | entity | 0.50 |
| SENESCENCE | co_discussed | entity | 0.50 |
| CHAPERONE-MEDIATED AUTOPHAGY | regulates | concept | 0.50 |
| RIBOSOME | associated_with | organelle | 0.45 |
| SOD1 | co_discussed | gene | 0.40 |
| TNF | co_discussed | gene | 0.40 |
| STING | co_discussed | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Astrocytes | involved_in | cell_type | 0.95 |
| HSPA8 | associated_with | gene | 0.95 |
| Autophagy | regulates | pathway | 0.95 |
| Ubiquitin-Proteasome System | associated_with | pathway | 0.95 |
| SYNCRIP | associated_with | protein | 0.95 |
| HSP90 | regulates | protein | 0.95 |
| Hsp110 | regulates | protein | 0.90 |
| ubiquitin-proteasome system | regulates | pathway | 0.90 |
| deubiquitinating enzymes | regulates | protein | 0.90 |
| autophagy | regulates | pathway | 0.90 |
| Deubiquitinating Enzymes | regulates | enzyme | 0.90 |
| SNCA | associated_with | protein | 0.90 |
| Pi3K/Akt | regulates | pathway | 0.90 |
| TARDBP | regulates | gene | 0.90 |
| HSP110 | regulates | protein | 0.90 |
| DJ1 | regulates | protein | 0.90 |
| HSP27 | regulates | protein | 0.90 |
| FUS | regulates | gene | 0.90 |
| HSP90 | regulates | protein | 0.90 |
| TFEB | promotes | gene | 0.85 |
| Ampk | regulates | pathway | 0.85 |
| RNA Binding Protein | involved_in | protein | 0.85 |
| DNAJB6 | regulates | protein | 0.85 |
| PARK7 | regulates | protein | 0.85 |
| HSP27 | regulates | protein | 0.85 |
| CLPP | involved_in | gene | 0.85 |
| TDP-43 | regulates | protein | 0.85 |
| Ribosome-Associated Quality Control | involved_in | process | 0.85 |
| Chronological Ageing | inhibits | process | 0.85 |
| Autophagy | associated_with | process | 0.85 |
| LONP1 | involved_in | gene | 0.85 |
| APEH | involved_in | enzyme | 0.85 |
| FUS | associated_with | protein | 0.80 |
| CTSD | modulates | gene | 0.80 |
| molecular_chaperones | maintains | protein_family | 0.80 |
| Lysosomal Ph Disruption | inhibits | process | 0.75 |
| YTHDF1 | modulates | protein | 0.75 |
| RAB7A hyperactivation | associated_with | phenotype | 0.75 |
| ALS | exacerbates | disease | 0.70 |
| MAPT | associated_with | gene | 0.70 |
| METTL3 | regulates | protein | 0.70 |
| ASTROCYTE | regulates | gene | 0.70 |
| TDP-43 | regulates | protein | 0.70 |
| SUMOylation | modulates | process | 0.70 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.70 |
| TAU | protects_against | protein | 0.70 |
| TH | activates | gene | 0.70 |
| protein quality control | regulates | pathway | 0.70 |
| TFEB | treats | gene | 0.70 |
| TFEB | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian-Synchronized Proteostasis Enhancement | 0.744 | neurodegeneration | Digital biomarkers and AI-driven early d |
| H1: T-Type Calcium Channel–Driven Calcium Overload and Prote | 0.730 | neurodegeneration | Entorhinal cortex layer II vulnerability |
| Proteostasis Enhancement via APOE Chaperone Targeting | 0.724 | neurodegeneration | Mechanistic role of APOE in neurodegener |
| HSF1 reprioritizes transcription and suppresses MAPT while r | 0.598 | neurodegeneration | Which specific transcription factors med |
| Transient Chaperone Priming Prior to Seed Inoculation Preven | 0.540 | protein folding | Can chaperone enhancement approaches ove |
| Mitochondrial Proteostasis Hijacking | 0.490 | neurodegeneration | What mechanisms underlie TDP-43's contri |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.624
neurodegeneration | 2026-04-03 | 44 hypotheses Top: 0.990
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Autophagy Enhancement Drug Screening for Neurodegeneration | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,900,000 |
| Experiment Index | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Macroautophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| N-of-1 Clinical Trial Design for CBS/PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Scoring Methodology | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of r [PMID:37086572] | Chunli Yang, Ziwei Deng, Qihang Zeng, Xi | Biochemical and biophysical re | 2023 | 1 |
| Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via ne [PMID:41539636] | ["Fu X", "Long Q", "Wang Z", "Yan S", "L | Journal of ethnopharmacology | 2026 | 0 |
| Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Agin [PMID:41521387] | ["Milan M", "Troyano-Rodriguez E", "Ihuo | Aging cell | 2026 | 0 |
| Cellular Models of Aging and Senescence. [PMID:40862757] | Kim B, Lee DI, Basisty N, Dai DF | Cells | 2025 | 0 |
| Circadian clock genes and cell survival in bipolar disorder: Insights into lithi [PMID:39995020] | ["Mishra H", "Wei H", "LeRoux M", "Ko D" | The FEBS journal | 2025 | 0 |
| Single nucleus RNA sequencing profile analysis to reveal cell type specific comm [PMID:40715263] | Pappu MAA, Alamin M, Sultana MH | Sci Rep | 2025 | 0 |
| Rapamycin mitigates neurotoxicity of fluoride and aluminum by activating autopha [PMID:40119168] | ["Tao D", "Xia Y", "Liao Q", "Yang X", " | Scientific reports | 2025 | 0 |
| Downregulation of NEAT1 due to loss of TDP-43 function exacerbates motor neuron [PMID:40661327] | Kawakami Y, Iguchi Y, Li J | Brain Commun | 2025 | 0 |
| Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Pers [PMID:41287625] | Namgyal D, Lim CS | Nature and science of sleep | 2025 | 0 |
| Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 [PMID:40202498] | ["Gu J", "Yang M", "Zhang L", "Liu Y", " | The Journal of cell biology | 2025 | 0 |
| Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the bra [PMID:40506775] | ["Kong J", "Xie Y", "Fan R", "Wang Q", " | European journal of medical re | 2025 | 0 |
| Circadian clock genes and insomnia: molecular mechanisms and therapeutic implica [PMID:41123484] | Ren Q, Gu M, Fan X | Ann Med | 2025 | 0 |
| Orexin-A and Circadian Disruption in Alzheimer's Disease: Implications for Amylo [PMID:41335394] | ["Singh R", "Kaur V", "Ash A", "Singh M" | Molecular neurobiology | 2025 | 0 |
| Differential contributions of circadian clock genes to cell survival in bipolar [PMID:38746315] | ["Mishra H", "Wei H", "LeRoux M", "Ko I" | Research square | 2024 | 0 |
| Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by [PMID:39596274] | ["Rokad D", "Harischandra D", "Samidurai | International journal of molec | 2024 | 0 |
| Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond. [PMID:37887295] | ["Statsenko Y", "Kuznetsov N", "Morozova | Cells | 2023 | 0 |
| Contributions of circadian clock genes to cell survival in fibroblast models of [PMID:37126998] | ["Mishra H", "Wei H", "Rohr K", "Ko I", | European neuropsychopharmacolo | 2023 | 0 |
| Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010] | Torrini C, Nguyen TTT, Shu C, Mela A, Hu | Molecular cell | 2022 | 0 |
| Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular c [PMID:35164882] | ["Liu F", "Morderer D", "Wren M", "Vettl | Acta neuropathologica communic | 2022 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.66 · 2026-04-25
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning Proteostasis in their description or question text