concept

CERAMIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CERAMIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

269Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CERAMIDE
Key Genes/Proteins	ACSL4, AKT, ALPHA-SYNUCLEIN, ALZHEIMER, AMYLOID, APOE
Related Diseases	AGING, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ceramide Signaling Pathway in Neurodegeneration

mechanism · 2973 words

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Pathway Diagram

flowchart TD
    N0["CERAMIDE"]
    N1["SMPD1"]
    N1 -->|"produces"| N0
    N2["APOE"]
    N2 -->|"treats"| N0
    N3["NEUROINFLAMMATION"]
    N0 -->|"activates"| N3
    N4["ENDOPLASMIC RETICULUM"]
    N0 -->|"regulates"| N4
    N5["TAU"]
    N0 -->|"activates"| N5
    N6["MITOCHONDRIAL DYSFUNCTION"]
    N0 -->|"causes"| N6
    N7["APP"]
    N0 -->|"inhibits"| N7
    N8["AXONAL TRANSPORT"]
    N0 -->|"inhibits"| N8
    N9["INSULIN RESISTANCE"]
    N0 -->|"activates"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 gene
    class N2 gene
    class N3 phenotype
    class N5 protein
    class N6 phenotype
    class N7 gene
    class N8 phenotype
    class N9 phenotype

Outgoing (155)

Target	Relation	Type	Str
Alzheimer's disease	contributes_to	disease	0.90
adipogenesis	suppresses	process	0.90
Tau Phosphorylation	promotes	process	0.90
tau phosphorylation	promotes	process	0.90
amyloid-beta	contributes_to	protein	0.90
Adipose Tissue Function	associated_with	process	0.90
Neuronal Apoptosis	promotes	process	0.90
Amyloid-Β	contributes_to	compound	0.90
SMS1	substrate_of	enzyme	0.90
Cerebral Ischemia/Reperfusion Injury	associated_with	disease	0.90
Ischemic Stroke	associated_with	disease	0.85
SMSR	binds	enzyme	0.85
neuronal apoptosis	promotes	process	0.85
AMYLOID-BETA	contributes_to	protein	0.85
Neuronal apoptosis	causes	process	0.85
Tau hyperphosphorylation	contributes_to	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.80
Glucose Homeostasis	associated_with	process	0.80
Adipose Tissue Function	regulates	process	0.80
Neuroapoptosis	contributes_to	process	0.80
Metabolic Health	associated_with	phenotype	0.80
APP	inhibits	gene	0.70
AXONAL TRANSPORT	inhibits	phenotype	0.70
NEUROINFLAMMATION	biomarker_for	phenotype	0.70
INSULIN RESISTANCE	activates	phenotype	0.70
INSULIN RESISTANCE	regulates	phenotype	0.70
Insulin Resistance	causes	phenotype	0.70
AGING	regulates	phenotype	0.70
MITOCHONDRIAL DYSFUNCTION	causes	phenotype	0.70
AGING	activates	phenotype	0.70
TAU	activates	protein	0.70
Apoptosis	associated_with	entity	0.70
Apoptosis	interacts_with	entity	0.70
Apoptosis	activates	entity	0.70
NEUROINFLAMMATION	activates	phenotype	0.70
AMYLOID	associated_with	protein	0.70
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
NEUROINFLAMMATION	interacts_with	phenotype	0.65
ALPHA-SYNUCLEIN	regulates	protein	0.65
AMYLOID	causes	protein	0.65
INSULIN RESISTANCE	produces	phenotype	0.65
NEURODEGENERATION	regulates	disease	0.65
NEURODEGENERATION	interacts_with	disease	0.65
PYROPTOSIS	activates	phenotype	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
LYSOSOMAL DYSFUNCTION	activates	phenotype	0.65
NEURODEGENERATION	activates	disease	0.65
OXIDATIVE STRESS	interacts_with	phenotype	0.65
PINK1	interacts_with	gene	0.65
CTSD	regulates	gene	0.65

Incoming (114)

Source	Relation	Type	Str
Myriocin	associated_with	drug	0.95
CERS5	associated_with	gene	0.90
Myriocin	downregulates	drug	0.90
SPT	catalyzes	enzyme	0.90
CERS2	associated_with	gene	0.90
SMSR	regulates	enzyme	0.85
Neutral sphingomyelinase inhibitors	inhibits	drug	0.85
Neutral Sphingomyelinase Inhibitors	inhibits	drug	0.85
APOE	regulates	gene	0.85
neutral sphingomyelinase inhibitors	inhibits	drug	0.85
serine palmitoyltransferase inhibitors	inhibits	drug	0.85
APOE4	exacerbates	gene	0.80
LDL	interacts_with	protein	0.80
VLDL	interacts_with	protein	0.80
VLDL	transports	protein	0.80
LDL	transports	protein	0.80
liver-gut-brain axis	regulates	pathway	0.75
AMYLOID	produces	protein	0.70
APP	treats	gene	0.70
CANCER	destabilizes	disease	0.70
OXIDATIVE STRESS	activates	phenotype	0.70
APP	activates	gene	0.70
Apoptosis	interacts_with	entity	0.70
Apoptosis	associated_with	entity	0.70
APOE	causes	gene	0.70
APOE	regulates	gene	0.70
ENDOPLASMIC RETICULUM STRESS	causes	phenotype	0.70
APOE	treats	gene	0.70
APOE	activates	gene	0.70
APOE	inhibits	gene	0.70
GOLGI APPARATUS	regulates	organelle	0.65
LRRK2	regulates	gene	0.65
AKT	regulates	gene	0.65
MITOPHAGY	exacerbates	phenotype	0.65
MITOPHAGY	interacts_with	phenotype	0.65
INSULIN RESISTANCE	interacts_with	phenotype	0.65
MINOCYCLINE	activates	drug	0.65
FINGOLIMOD	encodes	drug	0.65
GBA	encodes	gene	0.65
OXIDATIVE STRESS	degrades	phenotype	0.60
APOE	expressed_in	gene	0.60
SPHINGOMYELIN	participates_in	phenotype	0.55
inflammation	regulates	pathway	0.50
inflammation	interacts_with	pathway	0.50
IL-10	interacts_with	protein	0.50
IL-10	activates	protein	0.50
CERS2	interacts_with	gene	0.50
SPTLC1	inhibits	gene	0.50
SPTLC1	activates	gene	0.50
ALZHEIMER	inhibits	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduct	0.732	neurodegeneration	How do sphingomyelin/ceramide ratios spe

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468]	["Hsu-Heng Lin", "Hui-An Chen", "Shyh-Je	Molecular genetics & genom	2026
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198]	["Aron Park", "Baeki E Kang", "Eun-Ju Ji	Genes & genomics	2026
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606]	Yu X MD, Lei J MSc, Du X MSc, He Y MSc,	Int J Surg	2026
Plasma metabolites may inhibit childhood obesity by regulating ferroptosis throu [PMID:41249848]	Wang JG, Pan XH, Li Y	Int J Obes (Lond)	2026
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198]	Park A, Kang BE, Jin EJ, Kim HJ, Lee CW	Genes Genomics	2026
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160]	Jia J, Gan Y, Li J, Li L, Meng H et al.	Adv Sci (Weinh)	2026
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468]	Lin HH, Chen HA, Lin SJ, Hsu RH, Lee NC	Mol Genet Genomic Med	2026
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160]	Jia J, Gan Y, Li J, Li L, Meng H, Sun M,	Advanced science (Weinheim, Ba	2026
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606]	Yu X, Lei J, Du X, He Y, Peng W, Yang R,	International journal of surge	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CERAMIDE in their description or question text

No additional research found