Contents

CTSD — Cathepsin D

🧬 Gene Info

Gene Symbol	CTSD
Full Name	Cathepsin D
Aliases	CPSD, CLN10
Chromosome	11p15.5
Protein Type	Protease
Function	is a lysosomal aspartic protease encoded by the CTSD gene.
Primary Expression	Brain, liver, macrophages, neurons, microglia
Molecular Weight	48 kDa
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P07339
NCBI Gene ID	1509
Ensembl ID	ENSG00000103811
GeneCards	CTSD
Human Protein Atlas	CTSD
N-terminal lobe	Contains the activation peptide (propeptide, ~44 amino acids) that blocks the active site; cleavage of this peptide is required for activation
Associated Diseases	AD, ADH, Aging, ALI, Als
Known Drugs/Compounds	CHLOROQUINE, COENZYME Q10, H2S, rapamycin, RAPAMYCIN
Interactions	ABCA1, ABCD3, ACTB, Actin, ADRA2A, AGING
KG Connections	1555 knowledge graph edges
Databases	GeneCards HPA STRING

No AI portrait yet

Knowledge Graph