concept

PARKINSON DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARKINSON DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

297Connections

0Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

5Debates

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💡 Concept Info

Name	PARKINSON DISEASE
Key Genes/Proteins	ACHE, AD, AIF1, AKT, ALS, AMPK
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
Related Pathways	APOPTOSIS

Pathway Diagram

graph TD
    PARKINSON_DISEASE["PARKINSON DISEASE"]
    PARKINSON_DISEASE -->|"risk_factor_for"| Dementia["Dementia"]
    PARKINSON_DISEASE -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
    Rotenone["Rotenone"] -->|"causes"| PARKINSON_DISEASE
    PRKN["PRKN"] -->|"risk_factor_for"| PARKINSON_DISEASE
    Mitochondrial_Dysfunction["Mitochondrial Dysfunction"] -->|"contributes to"| PARKINSON_DISEASE
    Vinpocetine["Vinpocetine"] -.protects against.-> PARKINSON_DISEASE
    Ageing["Ageing"] -->|"risk_factor_for"| PARKINSON_DISEASE
    Snca["Snca"] -.biomarker for.-> PARKINSON_DISEASE
    GBA["GBA"] -->|"risk_factor_for"| PARKINSON_DISEASE

Outgoing (72)

Target	Relation	Type	Str
Dementia	causes	disease	0.95
Dementia	risk_factor_for	disease	0.95
Dementia Risk	risk_factor_for	phenotype	0.95
Cognitive Impairment	causes	phenotype	0.92
Cognitive Decline	associated_with	phenotype	0.90
TFEB	co_discussed	gene	0.60
PD	markers	gene	0.60
PD	mediates	gene	0.60
RAGE	associated_with	gene	0.60
TAU	associated_with	gene	0.60
TAU	enhances	gene	0.60
STING	co_discussed	gene	0.60
TAU	co_discussed	gene	0.60
SOD1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
STING	regulates	gene	0.60
TAU	interacts_with	gene	0.60
SQSTM1	inhibits	gene	0.60
TAU	targets	gene	0.60
PD	regulates	gene	0.60
SNCA	interacts_with	gene	0.60
PD	activates	gene	0.60
PINK1	activates	gene	0.60
SQSTM1	activates	gene	0.60
SRC	activates	gene	0.60
STAT3	activates	gene	0.60
STING	activates	gene	0.60
TNF	activates	gene	0.60
TRAF6	activates	gene	0.60
ULK1	activates	gene	0.60
RAS	activates	gene	0.60
PARKINSON'S DISEASE	activates	disease	0.60
PD	interacts_with	gene	0.60
RB1	activates	gene	0.60
SIRT1	activates	gene	0.60
TFEB	activates	gene	0.60
TP53	activates	gene	0.60
SNCA	co_discussed	gene	0.60
SNCA	activates	gene	0.60
TH	activates	gene	0.60
SNCA	associated_with	gene	0.60
RAGE	interacts_with	gene	0.60
VCP	activates	gene	0.60
PYCARD	expresses	gene	0.60
SNCA	expresses	gene	0.60
SQSTM1	expresses	gene	0.60
TH	regulates	gene	0.60
TNF	expresses	gene	0.60
SOD1	activates	gene	0.60
TARDBP	activates	gene	0.60

Incoming (225)

Source	Relation	Type	Str
entities-atp7b-gene	associated_with	wiki	0.00
Reactive Oxygen Species	contributes_to	process	0.95
GBA1	risk_factor_for	gene	0.95
Levodopa	treats	drug	0.95
Mitochondrial Dysfunction	contributes_to	process	0.95
Neural Mitochondrial Dysfunction	contributes_to	process	0.95
LRRK2	causes	gene	0.95
Vinpocetine	protects_against	drug	0.95
SNCA	associated_with	gene	0.95
LRRK2	risk_factor_for	gene	0.95
Snca	biomarker_for	biomarker	0.95
GBA	risk_factor_for	gene	0.95
Neuroinflammation	contributes_to	process	0.95
Rotenone	causes	compound	0.95
PINK1	associated_with	gene	0.95
PRKN	risk_factor_for	gene	0.95
Ageing	risk_factor_for	process	0.95
NLRP3	risk_factor_for	gene	0.90
Autophagy	involved_in	process	0.90
LRRK2	associated_with	gene	0.90
NLRP3	involved_in	protein	0.90
GBA mutations	risk_factor_for	gene	0.90
Lysosomal Dysfunction	contributes_to	mechanism	0.90
PBT434	treats	compound	0.90
Kaempferol	protects_against	compound	0.90
Hph-Rnpec	treats	drug	0.90
PINK1	risk_factor_for	gene	0.90
23266198	increase the risk for developing	paper	0.90
23266198	increase risk for	paper	0.90
Vinpocetine	treats	drug	0.90
LNK	associated_with	gene	0.90
TFEB	protective_against	gene	0.90
COMT	associated_with	gene	0.90
Astrocytes	contributes_to	cell_type	0.90
Oxidative Stress	contributes_to	process	0.90
GBA	contributes_to	gene	0.90
G2019S-Lrrk2 Mutation	risk_factor_for	phenotype	0.88
Ps1292-Lrrk2	biomarker_for	biomarker	0.88
Inflammasome	associated_with	pathway	0.85
HDAC6	associated_with	protein	0.85
SNCA	biomarker_for	gene	0.85
Icariin	treats	compound	0.85
MIRO1	associated_with	gene	0.85
NLRP3 inflammasome	implicated_in	complex	0.80
IL6	biomarker_for	protein	0.80
PI3K/AKT/mTOR	associated_with	pathway	0.80
AMBRA1	associated_with	protein	0.80
Myelin Repair	protects_against	process	0.80
LYSOSOMAL PROTEINS	causes	protein	0.80
NLRP3	implicated_in	gene	0.80