gene

NCF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

0Experiments

0Debates

Summary

NCF1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with Diabetes, Hepatitis, Inflammation. Connected to 43 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NCF1
Full Name	Neutrophil Cytosolic Factor 1
Chromosome	7q11.23
Protein Type	Enzyme
Function	NCF1 encodes the p47^phox^ subunit, a critical organizer of the NADPH oxidase complex.
Primary Expression	microglia, the resident immune cells of the brain
Amino Acids	340 aa
Pathways	Apoptosis, Ferroptosis, Toll-Like Receptor
UniProt ID	P14598
NCBI Gene ID	4748
Ensembl ID	ENSG00000158517
OMIM	608512
GeneCards	NCF1
Human Protein Atlas	NCF1
NADPH oxidase assembly	Essential for NOX2 activation in microglia
Associated Diseases	Alzheimer, Diabetes, Inflammation, Neuroinflammation, Parkinson
Interactions	ANG, FERROPTOSIS, INFLAMMATION, NRF2, Rb, STING
KG Connections	101 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCF1 — AlphaFold P14598 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NCF1 — Neutrophil Cytosolic Factor 1

gene · 564 words

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Pathway Diagram

graph TD
    NCF1["NCF1"]
    Inflammation{"Inflammation"}
    NCF1 -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    NCF1 -->|"therapeutic target"| Ms
    Parkinson{"Parkinson"}
    NCF1 -->|"therapeutic target"| Parkinson
    Diabetes{"Diabetes"}
    NCF1 -->|"therapeutic target"| Diabetes
    NCF1 -->|"associated with"| Parkinson
    NCF1 -->|"associated with"| Inflammation
    NCF1 -->|"associated with"| Diabetes
    Oxidative_Stress(["Oxidative Stress"])
    NCF1 -->|"therapeutic target"| Oxidative_Stress
    VIM["VIM"]
    NCF1 -->|"associated with"| VIM
    MMP9["MMP9"]
    NCF1 -->|"associated with"| MMP9
    CDC42["CDC42"]
    NCF1 -->|"associated with"| CDC42
    RAC1["RAC1"]
    NCF1 -->|"therapeutic target"| RAC1
    SOD2["SOD2"]
    SOD2 -->|"associated with"| NCF1
    CDC42 -->|"associated with"| NCF1
    CYCS["CYCS"]
    CYCS -->|"associated with"| NCF1
    GFAP["GFAP"]
    GFAP -->|"associated with"| NCF1
    RAC1 -->|"therapeutic target"| NCF1
    MET["MET"]
    MET -->|"therapeutic target"| NCF1
    MMP9 -->|"associated with"| NCF1
    VIM -->|"associated with"| NCF1
    TPM2["TPM2"]
    TPM2 -->|"therapeutic target"| NCF1
    GENES["GENES"]
    GENES -->|"associated with"| NCF1
    TPM2 -->|"associated with"| NCF1
    RAC1 -->|"associated with"| NCF1
    style NCF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (59)

Target	Relation	Type	Str
DNA Single-Strand Breaks	regulates	biomarker	0.75
Neuroinflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Hepatitis	activates	disease	0.65
Diabetes	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Apoptosis	regulates	pathway	0.60
Neutrophil	causes	cell_type	0.60
Ubiquitin	activates	protein	0.60
VIM	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
RAC1	therapeutic_target	gene	0.60
CYCS	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
TLR4	activates	gene	0.60
GFAP	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
TPM2	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
LPL	associated_with	gene	0.60
TNF	activates	gene	0.60
TREM2	activates	gene	0.60
CX3CR1	associated_with	gene	0.60
Rb	associated_with	protein	0.60
ANG	activates	gene	0.60
Rb	activates	protein	0.60
TH	associated_with	gene	0.60
Toll-Like Receptor	activates	pathway	0.60
AND	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
MGA	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
Microglia	associated_with	cell_type	0.60
DENND3	therapeutic_target	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
DENND3	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60

Incoming (42)

Source	Relation	Type	Str
ATOX1	upregulates	gene	0.80
CDC42	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
RAC1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
MMP9	associated_with	gene	0.60
VIM	associated_with	gene	0.60
TPM2	therapeutic_target	gene	0.60
CX3CR1	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
DENND3	associated_with	gene	0.60
DNA	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
GENES	associated_with	gene	0.60
LPL	associated_with	gene	0.60
TNF	activates	gene	0.60
DENND3	therapeutic_target	gene	0.60
MGA	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
MICROGLIA	associated_with	gene	0.60
MGA	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
TPM2	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
MET	associated_with	gene	0.60
NRF2	activates	gene	0.60
STING	activates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
GFAP	co_expressed_with	gene	0.50
MMP9	co_expressed_with	gene	0.50
TREM2	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NCF1 in their description or question text

No additional research found