gene

TPM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

50Outgoing

22Incoming

0Experiments

0Debates

Summary

TPM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Diabetes, Inflammation, Ms. Connected to 60 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TPM2
Full Name	Tropomyosin 2
Chromosome	9p13.3
Function	### Basic Actin-Binding Function
Amino Acids	284 aa
Pathways	Oxidative Stress
GeneCards	TPM2
Human Protein Atlas	TPM2
Associated Diseases	Diabetes, Inflammation, Parkinson, PD
KG Connections	74 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TPM2 — Tropomyosin 2

gene · 1363 words

→

TPM2 Protein — Tropomyosin 2

protein · 675 words

→

Pathway Diagram

graph TD
    TPM2["TPM2"]
    NEFL["NEFL"]
    TPM2 -->|"binds"| NEFL
    INA["INA"]
    TPM2 -->|"binds"| INA
    GIG["GIG"]
    TPM2 -->|"binds"| GIG
    ELANE["ELANE"]
    TPM2 -->|"regulates"| ELANE
    IL1B["IL1B"]
    TPM2 -->|"regulates"| IL1B
    IL8["IL8"]
    TPM2 -->|"regulates"| IL8
    RAC1["RAC1"]
    TPM2 -->|"associated with"| RAC1
    MGA["MGA"]
    TPM2 -->|"associated with"| MGA
    DENND3["DENND3"]
    TPM2 -->|"associated with"| DENND3
    Inflammation{"Inflammation"}
    TPM2 -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    TPM2 -->|"therapeutic target"| Ms
    Parkinson{"Parkinson"}
    TPM2 -->|"therapeutic target"| Parkinson
    SOD2["SOD2"]
    SOD2 -->|"therapeutic target"| TPM2
    CDC42["CDC42"]
    CDC42 -->|"therapeutic target"| TPM2
    CYCS["CYCS"]
    CYCS -->|"therapeutic target"| TPM2
    GFAP["GFAP"]
    GFAP -->|"therapeutic target"| TPM2
    RAC1 -->|"regulates"| TPM2
    MET["MET"]
    MET -->|"therapeutic target"| TPM2
    MMP9["MMP9"]
    MMP9 -->|"therapeutic target"| TPM2
    VIM["VIM"]
    VIM -->|"therapeutic target"| TPM2
    style TPM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

Target	Relation	Type	Str
Type 2 Diabetes Mellitus with Parkinson's Disease	upregulates	disease	0.80
ELANE	regulates	protein	0.80
GIG	binds	protein	0.80
NEFL	binds	protein	0.80
IL1B	regulates	protein	0.80
INA	binds	protein	0.80
IL8	regulates	protein	0.80
Type 2 Diabetes Mellitus	upregulates	disease	0.75
MGA	associated_with	gene	0.70
DENND3	associated_with	gene	0.70
RAC1	associated_with	gene	0.70
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
PD	associated_with	disease	0.60
NCF1	therapeutic_target	gene	0.60
SOD2	therapeutic_target	gene	0.60
GFAP	therapeutic_target	gene	0.60
VIM	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
CDC42	therapeutic_target	gene	0.60
RAC1	regulates	gene	0.60
CYCS	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
DENND3	regulates	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
CYCS	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
VIM	associated_with	gene	0.60
MET	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
NCF1	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
GENES	regulates	gene	0.60
MMP9	associated_with	gene	0.60
MYLK	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
AND	regulates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
CALD1	associated_with	gene	0.60
MGA	regulates	gene	0.60
HUB GENES	regulates	gene	0.60

Incoming (22)

Source	Relation	Type	Str
DIABETES MELLITUS	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
MGA	regulates	gene	0.60
DENND3	regulates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
GFAP	associated_with	gene	0.60
VIM	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
HUB GENES	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60
SOD2	therapeutic_target	gene	0.60
CDC42	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
GFAP	therapeutic_target	gene	0.60
RAC1	regulates	gene	0.60
MET	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
VIM	therapeutic_target	gene	0.60
NCF1	therapeutic_target	gene	0.60
RAC1	co_expressed_with	protein	0.50
SOD2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TPM2 in their description or question text

No additional research found