gene

arhgef7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arhgef7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

42Outgoing

20Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ARHGEF7
Full Name	Rho Guanine Nucleotide Exchange Factor 7
Chromosome	13q14.3
Function	This domain adopts a Dbl-like fold that facilitates the conformational changes required for GDP release and GTP binding.
Primary Expression	the brain, particularly in the cerebral cortex and hippocampus, where it localizes to [dendriti
Amino Acids	803 aa
Ensembl ID	ENSG00000150760
GeneCards	ARHGEF7
Human Protein Atlas	ARHGEF7
N-terminal SH3 Domain	Mediates interaction with proline-rich regions of target proteins, including PAKs and other signaling molecules
Dbl Homology (DH) Domain	The catalytic core that catalyzes GDP/GTP exchange on Rho GTPases
PH Domain (Pleckstrin Homology)	Involved in membrane localization and protein-lipid interactions
C-terminal PDZ Domain	Facilitates interaction with PDZ-domain containing proteins and contributes to scaffolding functions
Associated Diseases	Als
Interactions	AND, AUTOPHAGY, CDC42, LRRK2, MAPK, NEURON
KG Connections	57 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARHGEF7 Gene

gene · 1958 words

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Pathway Diagram

graph TD
    ARHGEF7["ARHGEF7"]
    ARHGEF7 -->|"regulates"| Dendritic_Spine_Morphogenesis["Dendritic Spine Morphogenesis"]
    ARHGEF7 -->|"activates"| RAC1["RAC1"]
    ARHGEF7 -->|"regulates"| Ms["Ms"]
    ARHGEF7 -->|"interacts"| Parkinson["Parkinson"]
    ARHGEF7 -->|"regulates"| Als["Als"]
    ARHGEF7 -->|"regulates"| ALS["ALS"]
    SRC["SRC"] -->|"phosphorylates"| ARHGEF7
    Glutamate["Glutamate"] -->|"activates"| ARHGEF7
    AMPA_RECEPTOR["AMPA RECEPTOR"] -->|"modulates"| ARHGEF7
    NMDA_RECEPTOR["NMDA RECEPTOR"] -->|"modulates"| ARHGEF7
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"interacts"| ARHGEF7
    RAB7L1["RAB7L1"] -->|"interacts"| ARHGEF7
    SYNAPSE["SYNAPSE"] -->|"regulates"| ARHGEF7

Outgoing (42)

Target	Relation	Type	Str
Dendritic Spine Morphogenesis	regulates	process	0.92
RAC1	activates	protein	0.90
Ms	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
Als	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Parkinson	interacts_with	disease	0.65
ALS	regulates	disease	0.65
AND	activates	gene	0.60
NEURON	activates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
SRC	regulates	gene	0.60
RAC1	regulates	gene	0.60
dendritic spine morphogenesis	regulates	process	0.60
Nmda Receptor	regulates	protein	0.60
Ampa Receptor	regulates	protein	0.60
LRRK2	associated_with	gene	0.60
LRRK2	expressed_in	gene	0.60
AND	regulates	gene	0.60
LRRK2	interacts_with	gene	0.60
RGS2	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
RAB5	interacts_with	gene	0.60
Dendritic Spine	regulates	pathway	0.60
LRRK2	inhibits	gene	0.60
Neuron	associated_with	cell_type	0.60
Actin	associated_with	protein	0.60
neurons	expressed_in	cell_type	0.60
Myosin	associated_with	protein	0.60
RAC1	interacts_with	gene	0.60
Neuron	activates	cell_type	0.60
AUTOPHAGY	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
SYNAPSE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55
Neuroblastoma	inhibits	disease	0.50
Neuron	activates	cell_type	0.50
NEURONS	interacts_with	concept	0.50

Incoming (20)

Source	Relation	Type	Str
Glutamate	activates	compound	0.87
SRC	regulates	gene	0.60
RAC1	regulates	gene	0.60
AND	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
PARKINSON	regulates	gene	0.60
AND	regulates	gene	0.60
LRRK2	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
RGS2	interacts_with	gene	0.60
LRRK2	inhibits	gene	0.60
PER	activates	gene	0.60
NEURON	activates	gene	0.60
RAB7L1	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
SYNAPSE	regulates	gene	0.60
LRRK2	associated_with	gene	0.50
LRRK2	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning arhgef7 in their description or question text

No additional research found