gene

RGS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

11Outgoing

14Incoming

0Experiments

0Debates

Summary

Page for RGS2 Gene - Regulator of G Protein Signaling 2

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🧬 Gene Info

Gene Symbol	RGS2
Full Name	Regulator of G Protein Signaling 2
Aliases	Page for RGS2 Gene, Page for RGS2 Protein
Chromosome	1q31.3
Function	RGS2 is a key negative regulator of G protein signaling
Primary Expression	many tissues:
Molecular Weight	24 kDa
UniProt ID	P41221
NCBI Gene ID	5997
Ensembl ID	ENSG00000147251
OMIM	600861
GeneCards	RGS2
Human Protein Atlas	RGS2
Associated Diseases	neurodegeneration
Interactions	ARHGEF7, AUTOPHAGY, CDC42, LRRK2, MAPK, PARKINSON
KG Connections	25 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RGS2 — AlphaFold P41221 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RGS2 Gene - Regulator of G Protein Signaling 2

gene · 578 words

→

RGS2 Protein - Regulator of G Protein Signaling 2

protein · 620 words

→

Pathway Diagram

graph TD
    RGS2["RGS2"]
    Parkinson{"Parkinson"}
    RGS2 -->|"interacts with"| Parkinson
    Ms{"Ms"}
    RGS2 -->|"interacts with"| Ms
    CDC42["CDC42"]
    RGS2 -->|"interacts with"| CDC42
    RAB5["RAB5"]
    RGS2 -->|"interacts with"| RAB5
    Autophagy(["Autophagy"])
    RGS2 -->|"interacts with"| Autophagy
    Mapk(["Mapk"])
    RGS2 -->|"interacts with"| Mapk
    neurodegeneration["neurodegeneration"]
    RGS2 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RGS2
    RAB7L1["RAB7L1"]
    RAB7L1 -->|"interacts with"| RGS2
    ARHGEF7["ARHGEF7"]
    ARHGEF7 -->|"interacts with"| RGS2
    RAC1["RAC1"]
    RAC1 -->|"interacts with"| RGS2
    LRRK2["LRRK2"]
    LRRK2 -->|"interacts with"| RGS2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| RGS2
    style RGS2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Carcinoma	regulates	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
RAB5	interacts_with	gene	0.60
FHL1	regulates	gene	0.60
Autophagy	interacts_with	pathway	0.60
AUTOPHAGY	interacts_with	gene	0.60
Mapk	interacts_with	pathway	0.60
CDC42	interacts_with	gene	0.60
DNA	associated_with	gene	0.60
ARHGEF7	interacts_with	gene	0.60

Incoming (14)

Source	Relation	Type	Str
CDC42	interacts_with	gene	0.60
DDB1	regulates	gene	0.60
RAB7L1	interacts_with	gene	0.60
ARHGEF7	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
CD163	expressed_in	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
LAMP2	expressed_in	gene	0.60
PICALM	expressed_in	gene	0.60
PIN1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RGS2 in their description or question text

No additional research found