protein

PSMA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

0Analyses

47Outgoing

23Incoming

0Experiments

0Debates

Summary

PSMA3 is a protein involved in neurodegeneration research. Key relationships include: interacts with, therapeutic target, regulates. Associated with Alzheimer, Cancer, Huntington. Connected to 40 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	PSMA3
Full Name	Proteasome 20S Subunit Alpha 3
Chromosome	14q23.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	28.1 kDa
Amino Acids	255 aa
Pathways	Autophagy, Proteasome
NCBI Gene ID	5684
Ensembl ID	ENSG00000172863
GeneCards	PSMA3
Human Protein Atlas	PSMA3
Associated Diseases	ALS, Alzheimer, dementia, neurodegeneration
Interactions	ACTB, ACTG1, AND, ATP5A1, CCT2, CDC42
KG Connections	70 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PSMA3 Gene

gene · 876 words

→

PSMA3 Protein

protein · 1155 words

→

Pathway Diagram

graph TD
    PSMA3["PSMA3"]
    Parkinson{"Parkinson"}
    PSMA3 -->|"therapeutic target"| Parkinson
    Alzheimer{"Alzheimer"}
    PSMA3 -->|"therapeutic target"| Alzheimer
    Huntington{"Huntington"}
    PSMA3 -->|"therapeutic target"| Huntington
    Ms{"Ms"}
    PSMA3 -->|"therapeutic target"| Ms
    PSMA3 -->|"interacts with"| Ms
    Cancer{"Cancer"}
    PSMA3 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    PSMA3 -->|"expressed in"| Tumor
    SOX2["SOX2"]
    PSMA3 -->|"interacts with"| SOX2
    YWHAZ["YWHAZ"]
    PSMA3 -->|"interacts with"| YWHAZ
    HSP90AB1["HSP90AB1"]
    PSMA3 -->|"interacts with"| HSP90AB1
    ACTB["ACTB"]
    PSMA3 -->|"interacts with"| ACTB
    CDC42["CDC42"]
    PSMA3 -->|"interacts with"| CDC42
    CCT2["CCT2"]
    CCT2 -->|"interacts with"| PSMA3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| PSMA3
    GFAP["GFAP"]
    GFAP -->|"interacts with"| PSMA3
    GRIA1["GRIA1"]
    GRIA1 -->|"interacts with"| PSMA3
    SNAP25["SNAP25"]
    SNAP25 -->|"interacts with"| PSMA3
    ACTG1["ACTG1"]
    ACTG1 -->|"interacts with"| PSMA3
    SNCA["SNCA"]
    SNCA -->|"interacts with"| PSMA3
    GAPDH["GAPDH"]
    GAPDH -->|"interacts with"| PSMA3
    MAPK1["MAPK1"]
    MAPK1 -->|"interacts with"| PSMA3
    style PSMA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

Target	Relation	Type	Str
Parkinson	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Prion	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
MAPK signaling	participates_in	pathway	0.60
SOX2	interacts_with	gene	0.60
YWHAZ	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PSMC1	regulates	gene	0.60
AMBRA1	regulates	gene	0.60
DDX20	regulates	gene	0.60
KIF23	associated_with	gene	0.60
KIF11	associated_with	gene	0.60
DNM1L	biomarker_for	gene	0.60
GRIA1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
SNAP25	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FN1	interacts_with	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Mapk	interacts_with	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
Proteasome	regulates	pathway	0.60
AND	interacts_with	gene	0.60
Immune Response	interacts_with	pathway	0.60
CANCER	expressed_in	gene	0.60
COL1A1	associated_with	gene	0.60
Autophagy	regulates	pathway	0.60
GENES	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
neurons	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
PSMD14	interacts_with	gene	0.60
RBFOX1	co_expressed_with	protein	0.50

Incoming (23)

Source	Relation	Type	Str
SOX2	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
FOXA2	interacts_with	gene	0.60
CCT2	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
PSMD14	interacts_with	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
FN1	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
ANO3	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSMA3 in their description or question text

No additional research found