concept

NADH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NADH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

394Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NADH is a concept in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with AD, ADH, ALI. Connected to 218 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NADH
Key Genes/Proteins	ACETYL-COA, ACTB, Actin, AGING, AIF, AKT
Related Diseases	AD, ADH, Aging, ALI, Als

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NADH["NADH"]
    NADH -->|"regulates"| Ischemia["Ischemia"]
    NADH -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    NADH -->|"regulates"| Tumor["Tumor"]
    NADH -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    NADH -->|"regulates"| Cancer["Cancer"]
    NADH -->|"activates"| Aging["Aging"]
    NADH -.protects against.-> Neuroinflammation["Neuroinflammation"]
    NADH -.protects against.-> Traumatic_Brain_Injury["Traumatic Brain Injury"]
    NADH -.protects against.-> Inflammation["Inflammation"]
    NADH -.protects against.-> Alzheimer["Alzheimer"]
    EEF2["EEF2"] -->|"binds"| NADH
    METHYLENE_BLUE["METHYLENE_BLUE"] -->|"interacts"| NADH
    MTOR["MTOR"] -->|"regulates"| NADH
    MYC["MYC"] -->|"regulates"| NADH
    EGFR["EGFR"] -->|"regulates"| NADH
    MTORC1["MTORC1"] -->|"regulates"| NADH
    RPS6["RPS6"] -->|"regulates"| NADH
    CTSD["CTSD"] -->|"regulates"| NADH
    ATG["ATG"] -->|"regulates"| NADH
    NAD["NAD"] -->|"regulates"| NADH

Outgoing (237)

Target	Relation	Type	Str
NAD+ metabolism	participates_in	pathway	0.85
Als	activates	disease	0.85
Cancer	associated_with	disease	0.75
SIRT1	activates	gene	0.75
Oxidative Stress	activates	pathway	0.70
MITOCHONDRIA	activates	gene	0.70
Mitochondrial Function	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
AMPK	protects_against	gene	0.65
Als	protects_against	disease	0.65
SQSTM1	activates	gene	0.65
RAPAMYCIN	regulates	drug	0.65
Parkinson	associated_with	disease	0.65
ALS	protects_against	disease	0.65
Stroke	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Anxiety	inhibits	disease	0.65
Stroke	implicated_in	disease	0.65
Huntington	associated_with	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Traumatic Brain Injury	therapeutic_target	disease	0.65
Parkinson	protects_against	disease	0.65
Als	inhibits	disease	0.65
Traumatic Brain Injury	protects_against	disease	0.65
neurons	expressed_in	cell_type	0.65
Lung Cancer	associated_with	disease	0.65
Stroke	activates	disease	0.65
Ischemia	protects_against	disease	0.65
Infection	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Sepsis	activates	disease	0.65
Fatty Liver	activates	disease	0.65
Diabetes	activates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	implicated_in	disease	0.65
Inflammation	protects_against	disease	0.65
Inflammation	implicated_in	disease	0.65
Stroke	protects_against	disease	0.65
Als	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	protects_against	disease	0.65
Dementia	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Obesity	activates	disease	0.65

Incoming (157)

Source	Relation	Type	Str
IDH1	associated_with	entity	0.90
IDH2	associated_with	entity	0.90
Methylene Blue	interacts_with	drug	0.90
EEF2	binds	gene	0.80
OXIDATIVE STRESS	activates	gene	0.70
NAD	inhibits	gene	0.70
CANCER	associated_with	gene	0.70
NAD	biomarker_for	gene	0.65
ATP	regulates	gene	0.65
ISCHEMIA	regulates	disease	0.65
NAD	causes	gene	0.65
METHYLENE_BLUE	interacts_with	drug	0.64
ANXIETY	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
CTCF	inhibits	gene	0.60
AGING	activates	gene	0.60
IL-1	associated_with	gene	0.60
BNIP3	regulates	gene	0.60
DHODH	regulates	gene	0.60
ACETYL-COA	associated_with	gene	0.60
FTH1	regulates	gene	0.60
KEAP1	regulates	gene	0.60
ATP	biomarker_for	gene	0.60
IDH2	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CANCER	regulates	gene	0.60
IDH1	regulates	gene	0.60
CD38	associated_with	gene	0.60
DNA	associated_with	gene	0.60
NAD	phosphorylates	gene	0.60
FSP1	regulates	gene	0.60
NRG1	regulates	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60
NAD	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
MTDNA	activates	gene	0.60
AMPK	associated_with	gene	0.60
ALS	interacts_with	gene	0.60
SREBF1	regulates	gene	0.60
ATP	expressed_in	gene	0.60
NAD	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
PPARA	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CPT1A	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
AGING	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do metabolomic alterations in glucose metabolism, mitochondrial function, an

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning NADH in their description or question text

No additional research found

NADH

Understanding Entity Pages

Summary

Wiki Pages (11)

NDUFS8 — NADH:Ubiquinone Oxidoreductase Core Subunit S8

NDUFAF2 — NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 2

NDUFAF4 — NADH Dehydrogenase Complex Assembly Factor 4

NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5

NDUFS3 Gene - NADH:Ubiquinone Oxidoreductase Core Subunit S3

NDUFAF1 — NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 1

NDUFAF8 Gene (NADH Dehydrogenase Complex Assembly Factor 8)

NDUFB1 — NADH:ubiquinone Oxidoreductase Subunit B1

MT-ND5 Protein (NADH Dehydrogenase 5)

MT-ND1 Gene - Mitochondrial NADH Dehydrogenase Subunit 1

NDUFA5 — NADH:ubiquinone Oxidoreductase Subunit A5