gene

NRG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

224Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NRG1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 127 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NRG1
Chromosome	8p21
Protein Family	Neuregulin family
Function	Induces receptor dimerization
Amino Acids	50 aa
Exons	20
Pathways	PI3K, MAPK
UniProt ID	Q7MZ64
NCBI Gene ID	3084
Ensembl ID	ENSG00000157140
GeneCards	NRG1
Human Protein Atlas	NRG1
Associated Diseases	Als, Bipolar, Bipolar Disorder, BIPOLAR_DISORDER, Depression
Interactions	ADRA1A, ADRA2A, ADRB1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections	224 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NRG1 — AlphaFold Q7MZ64 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NRG1 Gene

gene · 685 words

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NRG1 Protein

protein · 738 words

→

Pathway Diagram

graph TD
    NRG1["NRG1"]
    NRG1 -->|"inhibits"| Alzheimer["Alzheimer"]
    NRG1 -->|"inhibits"| Als["Als"]
    NRG1 -->|"inhibits"| Neuropathy["Neuropathy"]
    NRG1 -->|"activates"| Aging["Aging"]
    NRG1 -->|"activates"| Depression["Depression"]
    NRG1 -->|"activates"| Cardiovascular["Cardiovascular"]
    NRG1 -->|"activates"| Epilepsy["Epilepsy"]
    NRG1 -->|"activates"| Schizophrenia["Schizophrenia"]
    NRG1 -->|"activates"| Ms["Ms"]
    ERBB4["ERBB4"] -->|"contributes to"| NRG1
    RET["RET"] -->|"inhibits"| NRG1
    ERBB2["ERBB2"] -->|"inhibits"| NRG1
    GENES["GENES"] -->|"inhibits"| NRG1
    ERBB3["ERBB3"] -->|"inhibits"| NRG1
    DISC1["DISC1"] -->|"inhibits"| NRG1
    GLUD1["GLUD1"] -->|"inhibits"| NRG1
    LC3B["LC3B"] -->|"regulates"| NRG1
    MITOPHAGY["MITOPHAGY"] -->|"regulates"| NRG1

Outgoing (145)

Target	Relation	Type	Str
ERBB4	interacts_with	gene	0.90
Long-Term Potentiation	regulates	process	0.85
Als	regulates	disease	0.75
Bipolar Disorder	associated_with	disease	0.70
Alzheimer	activates	disease	0.65
Als	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Cardiac	regulates	disease	0.65
Ischemia	regulates	disease	0.65
ALS	associated_with	disease	0.65
Ms	activates	disease	0.65
Neuropathy	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
Depression	associated_with	disease	0.65
Depression	activates	disease	0.65
Anxiety	inhibits	disease	0.65
Schizophrenia	inhibits	disease	0.65
Ms	regulates	disease	0.65
Tumor	biomarker_for	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Schizophrenia	activates	disease	0.65
Aging	activates	disease	0.65
Bipolar	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Epilepsy	activates	disease	0.65
ERBB4	associated_with	gene	0.60
PS1	regulates	gene	0.60
PS1	activates	gene	0.60
PS1	associated_with	gene	0.60
DISC1	inhibits	gene	0.60
oligodendrocytes	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
App	associated_with	protein	0.60
ERBB4	activates	gene	0.60
cortex	expressed_in	brain_region	0.60
Albumin	associated_with	protein	0.60
Interneuron	activates	cell_type	0.60
HTR2A	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
hippocampus	expressed_in	brain_region	0.60
POLG	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.60

Incoming (79)

Source	Relation	Type	Str
ACETYL-COA	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
GABA	activates	gene	0.60
APP/PS1	activates	gene	0.60
GLUD1	inhibits	gene	0.60
NCAM1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
PDGFRA	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
ERBB3	activates	gene	0.60
HER3	activates	gene	0.60
G72	interacts_with	gene	0.60
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
RET	inhibits	gene	0.60
DISC1	inhibits	gene	0.60
ERBB4	inhibits	gene	0.60
KRAS	biomarker_for	gene	0.60
BDNF	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
DAO	associated_with	gene	0.60
ERBB4	contributes_to	gene	0.60
ERBB4	mediates	entity	0.60
CDK5	activates	gene	0.60
APP	activates	gene	0.60
ADRA1A	interacts_with	gene	0.60
ADRA2A	interacts_with	gene	0.60
ADRB1	interacts_with	gene	0.60
DBH	interacts_with	gene	0.60
ERBB4	interacts_with	gene	0.60
IL1RL1	interacts_with	gene	0.60
IL33	interacts_with	gene	0.60
APP	associated_with	gene	0.60
ERBB2	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ERBB3	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
GENES	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
AND	inhibits	gene	0.60
PDLIM5	associated_with	gene	0.60
BRAF	biomarker_for	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.743	neurodegeneration	What are the physiological functions of

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.743

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Neuregulin1-ErbB4 Signaling Involved in Acupuncture Promoting Myelin Regeneratio [PMID:41801841]	Shen J, Zhao Y, Jiang C, Huang Y, Wang L	J Vis Exp	2026	0

Debates (1)

Multi-agent debates referencing this entity

The abstract identifies BACE1 as an attractive drug target but doesn't address i

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

Related Research

Hypotheses and analyses mentioning NRG1 in their description or question text

No additional research found