concept

NAD+ METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAD+ METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

2Analyses

5Outgoing

50Incoming

0Experiments

3Debates

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💡 Concept Info

Name	NAD+ METABOLISM

Pathway Diagram

graph TD
    NAD__METABOLISM[NAD+ METABOLISM]
    NAD__METABOLISM -->|drives| cancer[cancer]
    NAD__METABOLISM -->|regulates| immune_system[immune system]
    NAD__METABOLISM -->|regulates| aging[aging]
    NAD__METABOLISM -->|regulates| Stemness[Stemness]
    SIRT1[SIRT1] -->|participates in| NAD__METABOLISM
    nicotinamide[nicotinamide] -->|modulates| NAD__METABOLISM
    neurodegeneration[neurodegeneration] -->|involves| NAD__METABOLISM
    NAD[NAD] -->|participates in| NAD__METABOLISM
    neurons[neurons] -->|active_in| NAD__METABOLISM
    NADH[NADH] -->|participates in| NAD__METABOLISM
    DAM_microglia[DAM microglia] -->|active_in| NAD__METABOLISM
    AMPK[AMPK] -->|participates in| NAD__METABOLISM
    ATP[ATP] -->|participates in| NAD__METABOLISM
    CD38[CD38] -->|regulates| NAD__METABOLISM

Outgoing (5)

Target	Relation	Type	Str
aging	regulates	process	0.85
cancer	drives	disease	0.85
immune system	regulates	pathway	0.85
Aging-Associated Diseases	associated_with	disease	0.80
Stemness	regulates	phenotype	0.75

Incoming (64)

Source	Relation	Type	Str
NADH	participates_in	gene	0.85
ATP	participates_in	gene	0.85
DAM microglia	active_in	cell_type	0.85
AMPK	participates_in	gene	0.85
NAD	participates_in	gene	0.85
neurons	active_in	cell_type	0.85
neurodegeneration	involves	disease	0.85
SIRT1	participates_in	gene	0.85
nicotinamide	modulates	drug	0.85
CD38	regulates	gene	0.80
DNA	participates_in	gene	0.75
PS1	participates_in	gene	0.75
astrocytes	active_in	cell_type	0.75
Alzheimer's disease	involves	disease	0.75
APP	participates_in	gene	0.75
PARP1	participates_in	gene	0.75
FOXO3	participates_in	gene	0.75
resveratrol	modulates	drug	0.75
NAMPT	participates_in	gene	0.75
SIRT3	participates_in	gene	0.75
NRF1	participates_in	gene	0.75
TFAM	participates_in	gene	0.75
Parkinson's disease	involves	disease	0.65
microglia	active_in	cell_type	0.65
FOXO	participates_in	gene	0.65
metformin	modulates	drug	0.65
neuroinflammation	involves	disease	0.65
CLOCK	participates_in	gene	0.65
SIRT6	participates_in	gene	0.65
BMAL1	participates_in	gene	0.65
HDAC3	participates_in	gene	0.55
ATG5	participates_in	gene	0.55
LC3	participates_in	gene	0.55
ATG7	participates_in	gene	0.55
HK2	participates_in	gene	0.55
TNF	participates_in	gene	0.55
SIRT7	participates_in	gene	0.55
NRF2	participates_in	gene	0.55
APOE4	participates_in	gene	0.55
PGC1A	participates_in	gene	0.55
TET2	participates_in	gene	0.55
PPARA	participates_in	gene	0.55
SREBF1	participates_in	gene	0.55
PPARGC1A	participates_in	gene	0.55
excitatory neurons	active_in	cell_type	0.55
TFEB	participates_in	gene	0.55
CD38	participates_in	gene	0.55
COX5A	participates_in	gene	0.55
RORB	participates_in	gene	0.55
STX17	participates_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.829

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.782

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04

Related Research

Hypotheses and analyses mentioning NAD+ METABOLISM in their description or question text

No additional research found