protein

FTH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FTH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

319Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

FTH1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with Aging, Als, Alzheimer. Connected to 155 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FTH1
Full Name	Ferritin Heavy Chain 1
Chromosome	19q13.33
Protein Family	Ferritin heavy chain subunit
Function	is a hallmark of multiple neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS)[@ward2014].
Molecular Weight	21 kDa
Exons	4
Pathways	Apoptosis, Blood-Brain Barrier, Ferroptosis, Metastasis, Mitophagy
UniProt ID	P02794
NCBI Gene ID	2495
Ensembl ID	ENSG00000196950
OMIM	134790
GeneCards	FTH1
Human Protein Atlas	FTH1
Ferroxidase center	Located in FTH1, catalyzes Fe2+ -> Fe3+ oxidation
Associated Diseases	ALS, Carcinoma, Hepatocellular Carcinoma, Parkinson's disease, stroke, Tumor
Known Drugs/Compounds	dimethyl malonate, paricalcitol
Interactions	ACSL4, ACTB, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
KG Connections	319 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FTH1 — AlphaFold P02794 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FTH1["FTH1"]
    FTH1 -->|"inhibits"| Ms["Ms"]
    FTH1 -->|"inhibits"| Depression["Depression"]
    FTH1 -->|"activates"| Fibrosis["Fibrosis"]
    FTH1 -->|"activates"| Als["Als"]
    FTH1 -->|"activates"| Parkinson["Parkinson"]
    FTH1 -->|"inhibits"| Alzheimer["Alzheimer"]
    TFR1["TFR1"] -->|"inhibits"| FTH1
    BECLIN1["BECLIN1"] -->|"activates"| FTH1
    GPX4["GPX4"] -->|"inhibits"| FTH1
    NRF2["NRF2"] -->|"inhibits"| FTH1
    ACSL4["ACSL4"] -->|"expressed in"| FTH1
    APP["APP"] -->|"inhibits"| FTH1
    SLC7A11["SLC7A11"] -->|"expressed in"| FTH1

Outgoing (213)

Target	Relation	Type	Str
iron homeostasis	regulates	process	0.90
Ferroptosis	inhibits	pathway	0.90
Ferroptosis	associated_with	process	0.85
Iron storage	mediates	process	0.85
NCOA4	inhibits	gene	0.80
FERROPTOSIS	inhibits	gene	0.80
NCOA4	associated_with	gene	0.80
Autophagy	associated_with	pathway	0.80
Carcinoma	associated_with	disease	0.75
Alzheimer	inhibits	disease	0.75
Als	inhibits	disease	0.75
Colorectal Cancer	activates	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Hepatocellular Carcinoma	associated_with	disease	0.75
GPX4	expressed_in	gene	0.70
ferroptosis	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
PTGS2	associated_with	gene	0.70
P62	associated_with	gene	0.70
NCOA4	activates	gene	0.70
Ferroptosis	activates	pathway	0.70
CANCER	activates	gene	0.70
Fibrosis	activates	disease	0.65
Depression	treats	disease	0.65
Ms	activates	disease	0.65
Alzheimer	treats	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Aging	treats	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
SQSTM1	activates	gene	0.60
FBXW7	associated_with	gene	0.60
P53	associated_with	gene	0.60
Ferroptosis	interacts_with	pathway	0.60

Incoming (106)

Source	Relation	Type	Str
iron	binds	compound	0.95
GPX4	associated_with	gene	0.70
SLC7A11	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
ELAVL1	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
COL1A1	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
ROS	associated_with	gene	0.70
P62	associated_with	gene	0.70
ATG	associated_with	gene	0.70
FERROPTOSIS	interacts_with	gene	0.70
APP	inhibits	gene	0.60
GPX4	expressed_in	gene	0.60
SLC7A11	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
PTGS2	expressed_in	gene	0.60
BECLIN1	inhibits	gene	0.60
TAU	inhibits	gene	0.60
IREB2	expressed_in	gene	0.60
P62	inhibits	gene	0.60
DMT1	expressed_in	gene	0.60
JNK	inhibits	gene	0.60
DHODH	regulates	gene	0.60
FSP1	regulates	gene	0.60
GPX4	activates	gene	0.60
KEAP1	regulates	gene	0.60
DMT1	associated_with	gene	0.60
FN1	associated_with	gene	0.60
ZFP36	associated_with	gene	0.60
HO-1	activates	gene	0.60
P53	expressed_in	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
C-JUN	associated_with	gene	0.60
DNA	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
ROS	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
LC3B	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
PARKINSON	activates	gene	0.60
ACSL4	expressed_in	gene	0.60
STROKE	activates	gene	0.60
TFR1	expressed_in	gene	0.60
GPX4	inhibits	gene	0.60
NRF2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglial subtypes in neurodegeneration — friend vs foe

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.685

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning FTH1 in their description or question text

No additional research found