gene 1,598 words KG: NDUFS5
Contents

NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5

🧬 Gene Info
Gene SymbolNDUFS5
Full NameNADH:Ubiquinone Oxidoreductase Core Subunit S5
Chromosome1p33
Protein FamilyComplex I accessory subunits
Functionencodes an accessory subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), the largest enzyme of the mitochondrial electron transport chain [[brandt1999]](https://pubmed.
Molecular Weight15 kDa
UniProt IDO43920
NCBI Gene ID4723
Ensembl IDENSG00000168653
OMIM603835
GeneCardsNDUFS5
Human Protein AtlasNDUFS5
7 Core (FMN-containing) subunitsForm the catalytic core
13 Iron-sulfur (FeS) clustersEnable electron transfer
Associated DiseasesParkinson's Disease, Leigh Syndrome, Mitochondrial Complex I Deficiency, Alzheimer's Disease
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
CBL Gene
gene · KG edge: associated_with
CRKL Gene
gene · KG edge: associated_with
DOCK1 Gene
gene · KG edge: associated_with
HSP90AB1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NDUFA2 associated_with NDUFS5
NDUFS6 associated_with NDUFS5
NDUFA1 associated_with NDUFS5
CBL associated_with NDUFS5
PDGFRB associated_with NDUFS5
HSP90AB1 associated_with NDUFS5
CRKL associated_with NDUFS5
DOCK1 associated_with NDUFS5
NDUFA12 associated_with NDUFS5
YWHAH associated_with NDUFS5

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