gene

FSP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FSP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for FSP1 Gene - Ferroptosis Suppressor Protein 1

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🧬 Gene Info

Gene Symbol	FSP1
Full Name	Ferroptosis Suppressor Protein 1 (Apoptosis-Inducing Factor Mitochondrial 2)
Aliases	Page for FSP1 Gene, Page for FSP1 Protein
Chromosome	10q22.1
Protein Type	Oxidoreductase
Function	Traps lipid peroxyl radicals: Direct radical-scavenging
Molecular Weight	35 kDa
Pathways	Differentiation, Ferroptosis, Lipid Metabolism, Oxidative Stress
UniProt ID	[Q9NSW9](https://www.uniprot.org/uniprot/Q9NSW9)
Ensembl ID	ENSG00000185730
GeneCards	FSP1
Human Protein Atlas	FSP1
Associated Diseases	ALS, Alzheimer, Cancer, Gastric Cancer, Huntington, multiple sclerosis
Known Drugs/Compounds	DEX
Interactions	ACSL4, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, ATP
KG Connections	238 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FSP1["FSP1"]
    Hypertension{"Hypertension"}
    FSP1 -->|"activates"| Hypertension
    Inflammation{"Inflammation"}
    FSP1 -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    FSP1 -->|"therapeutic target"| Ms
    Stroke{"Stroke"}
    FSP1 -->|"therapeutic target"| Stroke
    Alzheimer{"Alzheimer"}
    FSP1 -->|"therapeutic target"| Alzheimer
    Neurodegeneration{"Neurodegeneration"}
    FSP1 -->|"therapeutic target"| Neurodegeneration
    FSP1 -->|"protects against"| Ms
    FSP1 -->|"regulates"| Hypertension
    FSP1 -->|"regulates"| Ms
    KCNK2["KCNK2"]
    FSP1 -->|"activates"| KCNK2
    TRPV4["TRPV4"]
    FSP1 -->|"activates"| TRPV4
    KEAP1["KEAP1"]
    FSP1 -->|"interacts with"| KEAP1
    NRF2["NRF2"]
    NRF2 -->|"contributes to"| FSP1
    DEX["DEX"]
    DEX -->|"activates"| FSP1
    PIEZO1["PIEZO1"]
    PIEZO1 -->|"activates"| FSP1
    KCNK2 -->|"activates"| FSP1
    TRPC1["TRPC1"]
    TRPC1 -->|"activates"| FSP1
    TRPV4 -->|"activates"| FSP1
    GENES["GENES"]
    GENES -->|"activates"| FSP1
    GPX4["GPX4"]
    GPX4 -->|"interacts with"| FSP1
    GENES -->|"interacts with"| FSP1
    NRF2 -->|"interacts with"| FSP1
    GPX4 -->|"protects against"| FSP1
    CAT["CAT"]
    CAT -->|"protects against"| FSP1
    style FSP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (170)

Target	Relation	Type	Str
Ferroptosis	inhibits	process	0.90
ferroptosis	inhibits	process	0.85
Lipid Peroxidation	inhibits	process	0.85
ferroptosis	participates_in	pathway	0.70
Ferroptosis	regulates	pathway	0.70
Ms	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Huntington	inhibits	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Cancer	treats	disease	0.65
Chronic Kidney Disease	therapeutic_target	disease	0.65
Hypertension	regulates	disease	0.65
Macular Degeneration	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Huntington	activates	disease	0.65
Ataxia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Gastric Cancer	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Hypertension	activates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65

Incoming (68)

Source	Relation	Type	Str
Dexamethasone	upregulates	drug	0.90
NRF2	contributes_to	protein	0.85
GPX4	inhibits	gene	0.80
FERROPTOSIS	inhibits	gene	0.80
FERROPTOSIS	regulates	gene	0.70
DEX	activates	drug	0.64
NAD	inhibits	gene	0.60
GPX4	associated_with	gene	0.60
DHODH	inhibits	gene	0.60
GCH1	inhibits	gene	0.60
GPX4	regulates	gene	0.60
GCH1	regulates	gene	0.60
GENES	activates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
ROS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
CANCER	activates	gene	0.60
PIEZO	activates	gene	0.60
TREK-1	activates	gene	0.60
RAS	therapeutic_target	gene	0.60
DMT1	activates	gene	0.60
GPX4	activates	gene	0.60
GENES	interacts_with	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
CANCER	regulates	gene	0.60
GENES	inhibits	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
BACH1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
NAD	regulates	gene	0.60
DHODH	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
PARKINSON	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
RAS	activates	gene	0.60
AND	inhibits	gene	0.60
ACSL4	regulates	gene	0.60
BNIP3	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FSP1/CoQ10 Axis as GPX4-Independent Neuroprotective Pathway	0.480	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.847

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03

Related Research

Hypotheses and analyses mentioning FSP1 in their description or question text

No additional research found