gene

DHODH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHODH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

50Outgoing

10Incoming

0Experiments

0Debates

Summary

DHODH is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Als, Cancer, Fibrosis. Connected to 41 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DHODH
Full Name	Dihydroorotate Dehydrogenase
Chromosome	16q22.2
Protein Type	Enzyme
Function	encodes a mitochondrial inner membrane enzyme that catalyzes the fourth step in de novo pyrimidine biosynthesis — the oxidation of dihydroorotate to orotate.
Primary Expression	Ubiquitous (mitochondrial inner membrane); enriched in metabolically active neurons
Molecular Weight	43 kDa
Amino Acids	395 aa
Exons	10
Pathways	Ferroptosis
UniProt ID	Q02127
NCBI Gene ID	1723
Ensembl ID	ENSG00000102967
OMIM	126064
GeneCards	DHODH
Human Protein Atlas	DHODH
Associated Diseases	ALS
Interactions	ACSL4, AMPK, ATF3, ATP, CANCER, FERROPTOSIS
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DHODH — AlphaFold Q02127 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DHODH — Dihydroorotate Dehydrogenase

gene · 1634 words

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Pathway Diagram

graph TD
    DHODH["DHODH"]
    ferroptosis["ferroptosis"]
    DHODH -->|"regulates"| ferroptosis
    DHODH -->|"inhibits"| ferroptosis
    TP53["TP53"]
    DHODH -->|"regulates"| TP53
    ALOX15["ALOX15"]
    DHODH -->|"inhibits"| ALOX15
    small_cell_lung_cancer{"small cell lung cancer"}
    DHODH -->|"biomarker for"| small_cell_lung_cancer
    RNF115["RNF115"]
    DHODH -->|"stabilizes"| RNF115
    classical_swine_fever_virus["classical swine fever virus"]
    DHODH -->|"interacts with"| classical_swine_fever_virus
    MYC["MYC"]
    DHODH -->|"associated with"| MYC
    Cancer{"Cancer"}
    DHODH -->|"regulates"| Cancer
    Ferroptosis(["Ferroptosis"])
    DHODH -->|"regulates"| Ferroptosis
    neurodegeneration["neurodegeneration"]
    DHODH -->|"implicated in"| neurodegeneration
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"regulates"| DHODH
    CANCER["CANCER"]
    CANCER -->|"regulates"| DHODH
    style DHODH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
Als	activates	disease	0.75
Cancer	regulates	disease	0.75
ATP	activates	gene	0.70
Atherosclerosis	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Fibrosis	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Hepatitis	activates	disease	0.65
BNIP3	regulates	gene	0.60
Mitophagy	regulates	pathway	0.60
GENES	activates	gene	0.60
GCH1	inhibits	gene	0.60
FSP1	inhibits	gene	0.60
FSP1	regulates	gene	0.60
GPX4	activates	gene	0.60
KEAP1	regulates	gene	0.60
FTH1	regulates	gene	0.60
FER	regulates	gene	0.60
NRF2	regulates	gene	0.60
P62	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
Ferroptosis	inhibits	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Metastasis	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
Neuron	activates	cell_type	0.60
Glycolysis	activates	pathway	0.60
AMPK	inhibits	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60
OXIDATIVE STRESS	activates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
CANCER	activates	gene	0.60
ALS	associated_with	disease	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
GSH	activates	gene	0.60
NADH	regulates	gene	0.60
LONP1	activates	gene	0.60
ATF3	activates	gene	0.60
Ferroptosis	regulates	pathway	0.60
SCD1	activates	gene	0.60
GSH	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
ferroptosis	participates_in	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
CANCER	regulates	gene	0.70
BNIP3	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
GPX4	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
ROS	activates	gene	0.60
ACSL4	inhibits	gene	0.60
STING	inhibits	gene	0.60
AMPK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DHODH in their description or question text

No additional research found