concept

PERICYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERICYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

390Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	PERICYTES
Key Genes/Proteins	AD, AKT, ALS, AMPK, AMYLOID, APOE
Related Diseases	ALZHEIMER, ALZHEIMER'S, Alzheimer'S Disease, ALZHEIMER'S DISEASE
Related Pathways	APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Pericytes

cell · 2272 words

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Pathway Diagram

graph TD
    PERICYTES["PERICYTES"]
    style PERICYTES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PERICYTES -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    PERICYTES -->|"involved_in"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    PERICYTES -->|"regulates"| SENESCENCE["SENESCENCE"]
    PERICYTES -->|"activates"| VEGF([VEGF])
    SMAD3([SMAD3]) -->|"expressed in"| PERICYTES
    KATP([KATP]) -->|"expressed in"| PERICYTES
    PERICYTE["/PERICYTE/"] -->|"causes"| PERICYTES
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| PERICYTES
    ASTROCYTE["/ASTROCYTE/"] -->|"activates"| PERICYTES
    ASTROCYTES["/ASTROCYTES/"] -->|"activates"| PERICYTES
    ENDOTHELIAL["/ENDOTHELIAL/"] -->|"contributes to"| PERICYTES

Outgoing (56)

Target	Relation	Type	Str
Neurovascular Unit	component_of	process	0.95
Blood-Brain Barrier	involved_in	process	0.95
vascular barrier function	promotes	process	0.90
neurovascular_coupling	involved_in	unknown	0.85
blood-brain barrier integrity	associated_with	phenotype	0.85
Neurovascular Unit	involved_in	process	0.82
RAGE	markers	gene	0.70
BMP4	regulates	protein	0.70
VEGF	activates	gene	0.65
VEGF	inhibits	gene	0.60
STING	stabilizes	gene	0.60
ENDOTHELIAL CELLS	associated_with	cell_type	0.60
STING	interacts_with	gene	0.60
SMPD1	expresses	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
Alzheimer's disease	activates	disease	0.60
STING	targets	gene	0.60
calcium signaling	active_in	pathway	0.55
apoptosis pathway	active_in	pathway	0.55
blood-brain barrier	active_in	pathway	0.55
oxidative stress response	active_in	pathway	0.55
STROKE	co_discussed	entity	0.50
B CELLS	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
SPINAL CORD	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
PERICYTE	causes	entity	0.50
FIBROBLASTS	activates	concept	0.50
FIBROBLASTS	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
SLEEP	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
SMPD1	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
IPSC	activates	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
SENESCENCE	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
EXTRACELLULAR MATRIX	associated_with	concept	0.50
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
PRION-LIKE	co_discussed	entity	0.50
EXTRACELLULAR VESICLES	associated_with	concept	0.50
VEGF	co_discussed	gene	0.40
RAPAMYCIN	activates	drug	0.35
SENESCENCE	therapeutic_target	process	0.35
SENESCENCE	activates	process	0.35

Incoming (334)

Source	Relation	Type	Str
ENDOTHELIAL CELLS	interacts_with	cell_type	0.95
SMAD3	expressed_in	gene	0.95
25757756	maintain	paper	0.90
30340601	take up	paper	0.90
Ion Channels	expressed_in	protein	0.90
35165441	have two subtypes marked by	paper	0.90
KATP	expressed_in	protein	0.85
TMEM16A	expressed_in	gene	0.85
Alzheimer's disease	affects	disease	0.80
NEURONS	mediates	cell_type	0.70
OLIGODENDROCYTE	inhibits	cell_type	0.70
ASTROCYTE	mediates	cell_type	0.70
HUNTINGTON'S DISEASE	interacts_with	disease	0.70
ENDOTHELIAL	disrupts	cell_type	0.70
MICROGLIA	causes	cell_type	0.70
ASTROCYTE	causes	cell_type	0.70
LRRK2	associated_with	gene	0.70
PDGF	associated_with	gene	0.70
PERICYTE	degrades	cell_type	0.70
MICROGLIA	disrupts	cell_type	0.70
OLIGODENDROCYTES	disrupts	cell_type	0.70
OLIGODENDROCYTE	disrupts	cell_type	0.70
NEURONS	disrupts	cell_type	0.70
ASTROCYTE	disrupts	cell_type	0.70
PERICYTE	enhances	cell_type	0.70
APOE	stabilizes	gene	0.70
APOE	regulates	gene	0.70
NEURONS	enhances	cell_type	0.70
NEURONS	targets	cell_type	0.70
PERICYTE	targets	cell_type	0.70
ASTROCYTE	targets	cell_type	0.70
ENDOTHELIAL	targets	cell_type	0.70
MICROGLIA	interacts_with	cell_type	0.70
NEURONS	expresses	cell_type	0.70
PERICYTE	expressed_in	cell_type	0.70
ENDOTHELIAL	expresses	cell_type	0.70
MACROPHAGE	activates	cell_type	0.70
AMPK	activates	gene	0.70
CREB	activates	gene	0.70
MICROGLIA	expresses	cell_type	0.70
VEGFA	expressed_in	gene	0.70
ROS	expressed_in	gene	0.70
SARS	expressed_in	gene	0.70
unfolded protein response	active_in	pathway	0.70
PDGF	expressed_in	gene	0.65
PS1	expressed_in	gene	0.65
PERICYTE	regulates	cell_type	0.65
PERICYTE	causes	cell_type	0.65
OLIGODENDROCYTE	produces	cell_type	0.65
APP	expressed_in	gene	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pericyte-targeted senolysis or senomorphic therapy will bene	0.700	neurodegeneration	Does pericyte senescence drive BBB break
Chronic mTORC1-ULK1 signaling blocks autophagy initiation in	0.578	neurodegeneration	What specific autophagy pathways are def