Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IL2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, implicated in. Associated with Fibrosis, Ms. Connected to 11 entities in the SciDEX knowledge graph.
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| Gene Symbol | IL2 |
| Chromosome | 4q26 |
| Protein Type | Cytokine |
| Function | IL-2 has essential and complex functions: |
| Molecular Weight | 15 kDa |
| Pathways | PI3K, MAPK |
| NCBI Gene ID | 3559 |
| GeneCards | IL2 |
| Human Protein Atlas | IL2 |
| T cell proliferation | Primary cytokine driving activated T cell expansion[@malek2011] |
| Treg development | Essential for regulatory T cell (Treg) maintenance and function |
| NK cell activation | Enhances NK cell cytotoxicity and proliferation |
| Immune tolerance | Central to self-tolerance via Treg maintenance |
| Neurodevelopment | Influences neural precursor cell proliferation and differentiation |
| Synaptic plasticity | IL-2 receptor expression in hippocampus suggests roles in learning and memory |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, AKT1, MYC, PDGFR, VEGFA |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
IL2["IL2"]
Fibrosis{"Fibrosis"}
IL2 -->|"therapeutic target"| Fibrosis
Ms{"Ms"}
IL2 -->|"therapeutic target"| Ms
PI3K["PI3K"]
IL2 -->|"therapeutic target"| PI3K
MYC["MYC"]
IL2 -->|"interacts with"| MYC
AKT["AKT"]
IL2 -->|"interacts with"| AKT
AKT1["AKT1"]
IL2 -->|"interacts with"| AKT1
VEGFA["VEGFA"]
IL2 -->|"interacts with"| VEGFA
Pi3K(["Pi3K"])
IL2 -->|"therapeutic target"| Pi3K
Akt(["Akt"])
IL2 -->|"interacts with"| Akt
Tgf__(["Tgf-Beta"])
IL2 -->|"therapeutic target"| Tgf__
neurodegeneration["neurodegeneration"]
IL2 -->|"implicated in"| neurodegeneration
style IL2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fibrosis | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| neuroinflammation | regulates | disease | 0.60 |
| Pi3K | therapeutic_target | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
| Tgf-Β | therapeutic_target | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| MYC | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| VEGFA | interacts_with | gene | 0.60 |
| MCL1 | targets | gene | 0.60 |
| TNF | targets | gene | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| PDGFR | activates | gene | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| neurodegeneration | regulates | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IL2 in their description or question text
No additional research found