gene

HRAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HRAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

254Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HRAS is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Als, Cancer, Cardiac. Connected to 102 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HRAS
Chromosome	11p15.5
Protein Type	Gene
Function	is a prototype member of the Ras family of small GTPases that functions as a molecular switch in intracellular signaling pathways.
Primary Expression	medium spiny neurons of the striatum and in dopaminergic neurons of the substantia nigra pars compacta
Amino Acids	188 aa
Exons	6
Pathways	NF-κB
UniProt ID	P01112
NCBI Gene ID	3265
Ensembl ID	ENSG00000174775
GeneCards	HRAS
Human Protein Atlas	HRAS
Associated Diseases	Als, cancer, Fibrosis, Inflammation
Interactions	AKT, AND, BRAF, CANCER, GENE MUTATIONS, GENES
KG Connections	254 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HRAS — AlphaFold P01112 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

gene · 3426 words

→

Pathway Diagram

graph TD
    HRAS["HRAS"] -->|"therapeutic target"| Als["Als"]
    HRAS["HRAS"] -->|"therapeutic target"| Cardiac["Cardiac"]
    HRAS["HRAS"] -->|"therapeutic target"| Ms["Ms"]
    HRAS["HRAS"] -->|"therapeutic target"| Cancer["Cancer"]
    HRAS["HRAS"] -->|"regulates"| Als_1["Als"]
    HRAS["HRAS"] -->|"regulates"| Obesity["Obesity"]
    KCNH2["KCNH2"] -->|"therapeutic target"| HRAS["HRAS"]
    IDH1["IDH1"] -->|"therapeutic target"| HRAS["HRAS"]
    TP53["TP53"] -->|"therapeutic target"| HRAS["HRAS"]
    SCN5A["SCN5A"] -->|"therapeutic target"| HRAS["HRAS"]
    style HRAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (165)

Target	Relation	Type	Str
cancer	risk_factor_for	disease	0.95
cancer	causes	disease	0.95
Cancer	associated_with	disease	0.90
Mapk	activates	pathway	0.90
Cancer	therapeutic_target	disease	0.75
Mapk	therapeutic_target	pathway	0.70
KRAS	associated_with	gene	0.70
RAS	associated_with	gene	0.70
ALS	causes	disease	0.65
Depression	activates	disease	0.65
Ulcerative Colitis	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Obesity	regulates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	causes	disease	0.65
Fibrosis	causes	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Cardiac	activates	disease	0.65
Als	causes	disease	0.65
Ms	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
REL	regulates	gene	0.60
FOXO1	regulates	gene	0.60
GMM	interacts_with	gene	0.60
MMP9	associated_with	gene	0.60
MMP9	therapeutic_target	gene	0.60
MAPK14	therapeutic_target	gene	0.60
IGF1	regulates	gene	0.60
MAPK14	regulates	gene	0.60
NOS3	regulates	gene	0.60
PI3K	regulates	gene	0.60
PIK3R1	regulates	gene	0.60
SRC	regulates	gene	0.60
KRAS	expressed_in	gene	0.60
RAS	expressed_in	gene	0.60

Incoming (89)

Source	Relation	Type	Str
RAS	associated_with	protein	0.70
TP53	regulates	gene	0.60
MYC	regulates	gene	0.60
SOD2	regulates	gene	0.60
AKT	regulates	gene	0.60
HIF1A	regulates	gene	0.60
NOS3	regulates	gene	0.60
IGF1	regulates	gene	0.60
PIK3R1	regulates	gene	0.60
MAPK14	regulates	gene	0.60
PI3K	regulates	gene	0.60
SRC	regulates	gene	0.60
ACHE	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ANXA5	therapeutic_target	gene	0.60
IL6	regulates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ESR1	regulates	gene	0.60
NFKB	regulates	gene	0.60
RAS FAMILY	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
INFLAMMATION	causes	gene	0.60
AND	causes	gene	0.60
MAPK3	therapeutic_target	gene	0.60
BCL2L1	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
MAP2K1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
MAPK14	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
KDR	associated_with	gene	0.60
AKT	causes	gene	0.60
MAPK3	causes	gene	0.60
PIK3R1	causes	gene	0.60
PIK3CA	causes	gene	0.60
EGFR	causes	gene	0.60
JAK2	causes	gene	0.60
MTOR	causes	gene	0.60
INFLAMMATION	activates	gene	0.60
INS	activates	gene	0.60
EGFR	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HRAS in their description or question text

No additional research found